Test Price
450 AEDโ Home Collection Available
Immunohistochemistry E-Cadherin (ECAD) Test in Dubai | 450 AED | DHA Certified
Executive Summary & Core Metrics
Test Overview & Methodology
The Immunohistochemistry E-Cadherin (ECAD) test detects the expression of the E-Cadherin protein in formalin-fixed paraffin-embedded (FFPE) tissue or biopsy slides. It is crucial for differentiating lobular versus ductal breast carcinoma and identifying hereditary diffuse gastric cancer risk. The assay uses automated IHC platforms with validated primary antibodies, ensuring high specificity and sensitivity.
| Feature | Our IHC E-Cadherin Test | CDH1 Gene Sequencing (Alternative) |
|---|---|---|
| Precision | 99.9% sensitivity on FFPE tissue via automated IHC | Variable (depends on NGS coverage) |
| Methodology | Immunohistochemistry (IHC) | Next-Generation Sequencing (NGS) |
| Turnaround Time | 5โ7 days (tissue block/biopsy) | 10โ14 days |
| Clinical Utility | Protein loss assessment; guides surgical pathology | Germline mutation screening; hereditary cancer risk |
Physician Insight & Safety Protocols
Mr. Prabhakar Reddy Kalathoor | Specialist Diagnostic Radiology | DHA Registration ID: 61713011
โAn E-Cadherin IHC result must always be interpreted alongside the full histopathological context and clinical examination findings. Loss of expression can indicate lobular phenotype or diffuse-type gastric cancer, but false positives are rare with proper internal controls. I always recommend a multidisciplinary review before altering the treatment plan.โ
โ ๏ธ Medication Advisory
Do not discontinue prescribed medication without consulting your doctor. E-Cadherin testing does not affect ongoing therapies; abrupt cessation of targeted therapy or immunosuppressants can lead to disease progression.
Exclusion Criteria & Emergency Red Flags
- Insufficient tumor tissue (< 20% viable cells) may yield inconclusive results; re-biopsy advised.
- Decalcified bone biopsies are not suitable; false-negative E-Cadherin staining possible.
- If you experience sudden severe pain, bleeding, or infection at the biopsy site, seek emergency care immediately.
- This test is not a standalone screening; positive results require confirmatory CDH1 genetic testing if hereditary syndrome is suspected.
Patient FAQ & Clinical Guidance
1. How should I prepare for the E-Cadherin IHC test?
No fasting or medication changes are needed; simply submit the formalin-fixed biopsy or FFPE block along with the original histopathology report and clinical history for optimal processing. Our courier will arrange specimen retrieval at your convenience.
2. What does a โloss of E-Cadherin expressionโ mean for my cancer diagnosis?
It typically indicates lobular breast carcinoma or diffuse gastric cancer, guiding both surgical margin assessment and targeted therapy eligibility. Definitive treatment should be discussed with your oncologist after full histopathological correlation.
3. Is the E-Cadherin test covered by my UAE health insurance?
Most UAE insurers cover this when medically justified; our direct billing verification via WhatsApp at +971545488731 confirms your coverage immediately before sample collection.
UAE Regulatory & Data Privacy Adherence
DNA Labs UAE operates under DHA Facility License Number 1143 and is fully compliant with the following regulations:
- Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) โ ensuring all patient data are collected, processed, and stored with explicit consent and security.
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields โ governing electronic health records and telemedicine practices.
- Federal Decree-Law No. 4 of 2016 on Medical Liability โ establishing clear protocols for patient safety and clinical accountability.
ISO 9001:2015 certified (Certificate No. INT/EGQ/2509DA/3139) ensuring quality management across all laboratory processes.
Clinical & Logistical Metadata
| Test Name | Immunohistochemistry E-Cadherin (ECAD) |
| Price (AED) | 450 |
| Turnaround Time | 5โ7 business days |
| Sample Type / Matrix | FFPE tissue block or biopsy slides (archival) |
| Methodology Used | Immunohistochemistry (IHC) โ Automated Ventana or Dako platform |
| ICD-10-CM Code | C50.9, C16.9 |
| LOINC Code | 21922-0 |
| DHA Facility License & Address | License: 1143 | DNA Labs UAE, Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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