Test Price
2,800 AED✅ Home Collection Available
IL7R Gene Severe Combined Immunodeficiency, T-Cell Negative, B-Cell/NK-Cell Positive Type Genetic Test in UAE | 2,800 AED
Executive Summary & Core Metrics
Accuracy Guarantee & Premium Logistics
Accuracy Guarantee: 99.9% diagnostic sensitivity with next-generation sequencing (NGS) processed in our ISO 9001:2015-certified genetic laboratory.
Premium Logistics: VIP mobile phlebotomy and temperature-controlled cold-chain home collection available daily from 8 AM to 11 PM. Acceptable specimens include whole blood (EDTA), DNA FTA cards, or extracted DNA.
Clinical Guidance: Telephonic post-test clinical interpretation by a Consultant Medical Geneticist and access to a board-certified immunologist for result correlation.
Insurance & Billing: Direct billing verification and support via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
This advanced genetic test analyses the entire coding region of the IL7R gene using next-generation sequencing (NGS) to identify pathogenic variants causing severe combined immunodeficiency (SCID), specifically the T-cell negative, B-cell/natural killer cell-positive phenotype. The standard turnaround time for this comprehensive analysis is 3 to 4 weeks.
| Feature | Our Test (NGS) | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Diagnostic Precision | 99.9% sensitivity; detects single-nucleotide variants, indels, and copy-number changes across the entire coding region | Focused hotspots only; may miss deep intronic or large deletions |
| Methodology | Illumina NGS platform with advanced bioinformatic alignment, validated by Sanger confirmation | Capillary electrophoresis; limited scalability and throughput |
| Turnaround Speed | 3–4 weeks (expedited reporting available upon request) | 6–8 weeks typical processing time |
Physician Insight & Safety Protocols
"Genetic testing for IL7R-related SCID is a life-saving investigation. Results must be correlated with lymphocyte subsets and clinical history. A negative test does not exclude other forms of SCID; similarly, a variant of uncertain significance warrants familial segregation studies. Always consult a clinical immunologist before making therapeutic decisions." – Lina Osama Zaki Quteineh, Consultant Medical Genetics (DHA Registration ID: 9294403)
Medication Advisory
Do not discontinue any prescribed immunosuppressive or antimicrobial medication without explicit instruction from your treating physician. Genetic test results are a diagnostic aid and do not replace ongoing clinical management or emergency intervention.
Exclusion Criteria & Emergency Red Flags
- The test cannot be performed on haemolysed or severely lipaemic blood samples.
- Patients who have received allogeneic haematopoietic stem cell transplant within the last 90 days may have donor DNA interference.
- If the patient develops acute respiratory distress, persistent fever >38.5°C, or signs of severe infection while awaiting results, seek emergency care immediately and inform the laboratory.
- Individuals with known maternal cell contamination in previous genetic tests require a buccal swab or purified DNA from a hair root.
Patient FAQ & Clinical Guidance
1. What does this IL7R gene test detect?
This test identifies DNA mutations in the IL7R gene responsible for severe combined immunodeficiency with absent T cells but preserved B and NK cells. Variants disrupt interleukin-7 signalling, blocking T-cell development. The report classifies pathogenic, likely pathogenic, and uncertain variants according to ACMG guidelines, enabling precise diagnosis and early intervention.
2. How is the sample collected and what preparation is required?
VIP mobile phlebotomy and temperature-controlled cold-chain home collection by a DHA-licensed phlebotomist requires only a small blood volume or a drop on an FTA card. No fasting is necessary. A genetic counselling session to draw a detailed pedigree is mandatory before the test to maximise interpretive accuracy. The nurse will verify your clinical history and identity, and samples are shipped to our ISO-certified facility immediately.
3. Who should consider this test?
Newborns with abnormal TREC assay results, infants with recurrent or severe infections, or families with a history of unexplained early death should test urgently. Adults with idiopathic lymphopenia or suspected delayed-onset combined immunodeficiency also benefit. The test is approved for minors under strict parental consent and genetic counselling protocols in adherence with UAE Federal Law.
UAE Regulatory & Data Privacy Adherence
Data Privacy & Legal Compliance Framework
This service strictly adheres to the Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical safety and patient consent protocols follow Federal Decree-Law No. 4 of 2016 on Medical Liability. All patient data is encrypted and stored within UAE sovereign data centres.
Laboratory Facility License: DHA 1143 | ISO 9001:2015 Certified
Home Collection Hours: 8 AM – 11 PM daily. WhatsApp Support: +971 54 548 8731
Medical Director: Lina Osama Zaki Quteineh, Consultant Medical Genetics (DHA 9294403) | © 2025 DNA Labs UAE
Clinical & Logistical Metadata
| Test Name | IL7R Gene Severe Combined Immunodeficiency, T-Cell Negative, B-Cell/NK-Cell Positive Type Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 weeks (Expedited reporting available upon request) |
| Sample Type / Matrix | Whole Blood (EDTA), DNA FTA Card, or Extracted DNA |
| Methodology Used | Next-Generation Sequencing (NGS) with Sanger confirmation |
| ICD-10-CM Code | D81.2 (Severe combined immunodeficiency with low or normal B-cell numbers) |
| LOINC Code | 94477-8 (IL7R gene mutation analysis in Blood or Tissue by NGS) |
| DHA Facility License & Address | DHA License No: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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