Test Price
2,800 AED✅ Home Collection Available
DOCK8 Gene (Hyper-IgE Syndrome, Autosomal Recessive) Genetic Test in UAE | 2,800 AED | DHA Licensed
Executive Summary & Core Metrics
Trusted UAE-based Next-Generation Sequencing (NGS) for DOCK8 gene mutation detection, delivering 99.9% diagnostic sensitivity under ISO 9001:2015 accredited processing. Benefit from premium VIP Mobile Phlebotomy and temperature-controlled cold-chain home collection available daily from 8 AM to 11 PM. Post-test clinical guidance is provided via teleconsultation with board-certified molecular geneticists. Verify direct insurance billing through our WhatsApp support at +971 54 548 8731.
Test Overview & Methodology
This definitive genetic test sequences the entire DOCK8 gene using targeted Next-Generation Sequencing to confirm autosomal recessive hyper-IgE syndrome, characterized by severe eczema, recurrent staphylococcal abscesses, and markedly elevated serum IgE levels. Early molecular diagnosis in the UAE empowers targeted multidisciplinary management and informed family planning, eliminating diagnostic delays commonly associated with overseas non-specialized laboratories.
| Feature | Our DOCK8 NGS Test | Closest Alternative (Traditional Sanger / Overseas) |
|---|---|---|
| Methodology | Targeted Next-Generation Sequencing (full coding exons + splice sites) | Sanger sequencing limited to known hotspots, may miss deep intronic variants |
| Turnaround Time | 3–4 Weeks | 4–6 Weeks plus international shipping delays |
| Diagnostic Sensitivity | 99.9% validated against clinical reference standards | ~95% incomplete gene coverage |
| Accreditation | DHA Licensed Facility (1143), ISO 9001:2015 | May lack DHA-specific oversight and local regulatory compliance |
Physician Insight & Safety Protocols
“As a Consultant Medical Genetics specialist, I witness the transformative impact of early DOCK8 molecular confirmation. A definitive genetic result enables our multidisciplinary team to deploy targeted therapeutic strategies and deliver precise reproductive counseling. While this test provides indispensable molecular evidence, clinical correlation with immune phenotyping and comprehensive patient evaluation remains essential for optimal management. We strongly recommend pre-test genetic counseling to document family history and prepare families for result interpretation.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics (DHA Registration ID: 9294403)
Advisory & Medication Safety Notice
Important: Do not discontinue any prescribed corticosteroids, antibiotics, or immunosuppressive medications without explicit instruction from your treating physician. Genetic test preparation does not require interruption of essential therapy.
Exclusion Criteria & Emergency Red Flags
- This test is not suitable during acute anaphylactic reactions, severe sepsis, or unstable critical illness. Seek emergency medical care immediately.
- Do not rely solely on this genetic result for urgent clinical decisions. Always correlate with immunological and infectious disease evaluations.
- Seek urgent medical attention if you experience: sudden worsening of eczema accompanied by high fever, rapid progression of skin abscesses, signs of pneumonia or respiratory distress, or severe allergic reactions.
Patient FAQ & Clinical Guidance
1. How accurate is the DOCK8 NGS test for diagnosing hyper-IgE syndrome?
The DOCK8 NGS assay achieves a diagnostic sensitivity of 99.9% by analyzing all coding exons and splice sites. This method detects point mutations, small insertions or deletions, and copy number variations within the gene, eliminating false negatives common in older technologies. Results are interpreted by board-certified molecular geneticists in accordance with current ACMG guidelines, ensuring every report meets the highest standard for clinical validity in autosomal recessive hyper-IgE syndrome.
2. Who should consider DOCK8 genetic testing in the UAE?
Individuals with early-onset severe eczema, recurrent staphylococcal abscesses, and substantially elevated serum IgE levels should pursue testing. Children with persistent molluscum contagiosum, chronic mucocutaneous candidiasis, or a family history of immunodeficiency are prime candidates. This test is also indicated for asymptomatic siblings of confirmed cases to establish carrier status and for couples planning a family when both partners are known carriers, especially within consanguineous populations common in the region.
3. What does the 2,800 AED cost include and how is insurance handled?
The 2,800 AED fee covers home sample collection via VIP Mobile Phlebotomy, NGS analysis, and a comprehensive clinical report with interpretation. It also includes a pre-test genetic counseling session and post-test telephonic guidance to discuss your results with a specialist. For insurance claims, we offer direct billing verification via WhatsApp +971 54 548 8731. Our team will confirm your coverage under hereditary disorder diagnostics and obtain pre-approval from DHA-recognized insurers, ensuring a seamless patient experience fully compliant with UAE data protection regulations.
UAE Regulatory & Data Privacy Adherence
DNA Labs UAE operates under the regulatory oversight of the Dubai Health Authority (DHA Facility License Number: 1143) and strictly adheres to all applicable UAE federal laws governing patient data, clinical safety, and laboratory practice.
- Data Protection: All patient genetic information is processed in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
- Clinical Safety & Consent: Patient consent and clinical safety protocols are governed by Federal Decree-Law No. 4 of 2016 on Medical Liability, ensuring all procedures meet the highest standards of care.
- Accredited Laboratory Operations: Our facility maintains ISO 9001:2015 certification and follows stringent quality control measures for all molecular diagnostic workflows.
Clinical & Logistical Metadata
| Test Name | DOCK8 Gene (Hyper-IgE Syndrome, Autosomal Recessive) Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Whole Blood (Peripheral) — VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily 8 AM – 11 PM |
| Methodology Used | Targeted Next-Generation Sequencing (full coding exons + splice sites) |
| ICD-10-CM Code | D82.4 |
| LOINC Code | 94231-1 |
| DHA Facility License & Address | DHA Facility License Number: 1143 — Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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