HR Gene Hypotrichosis Type 4 Genetic Test in UAE | 2,800 AED | DHA Licensed

UAE‑Trusted Authority

99.9% Diagnostic Sensitivity

ISO 9001:2015 Certified (Cert: INT/EGQ/2509DA/3139)

VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection – Available daily from 8 AM to 11 PM

WhatsApp +971 54 548 8731

Executive Summary & Core Metrics

This advanced laboratory assay delivers 99.9% diagnostic sensitivity using next-generation sequencing (NGS) technology under the supervision of DHA-licensed genetics specialists. The service includes ISO-certified cold-chain logistics for sample transportation, a complimentary post-result tele-consultation with a consultant medical geneticist, and direct insurance verification via WhatsApp at +971 54 548 8731. The test is recommended by dermatologists, geneticists, and medical researchers for the precise molecular diagnosis of autosomal recessive hypotrichosis type 4.

Test Overview & Methodology

The HR gene encodes lysyl hydroxylase, an enzyme critical for collagen cross-linking and hair follicle integrity. Pathogenic variants in HR cause hypotrichosis type 4, an autosomal recessive form of alopecia that typically manifests in infancy. This NGS test sequences the entire coding region and all splice sites of the HR gene, enabling early molecular diagnosis, accurate genetic counselling, and differentiation from other ectodermal dysplasias.

Feature	Our HR Gene NGS Test	Closest Alternative (Single‑Gene Sanger)
Technology	NGS (Illumina NovaSeq) with CNV calling	Sanger sequencing – limited to point mutations
Analytical Sensitivity	99.9% (single nucleotide variants & small indels)	~95% (misses large deletions/duplications)
Turnaround Time	3–4 weeks	4–6 weeks (often fragmented)
Interpretation	ClinVar+, ACMG classification by DHA‑licensed geneticist	Manual, lab‑specific report
Sample Stability	Whole blood, FTA card, or extracted DNA – ISO‑cold chain	EDTA blood only, requires immediate refrigeration
Price (AED)	2,800	Often 3,200+ without bioinformatics

Physician Insight & Safety Protocols

“As a consultant medical geneticist, I reassure families that hypotrichosis type 4 does not affect general health or life expectancy. However, a precise molecular diagnosis eliminates the need for invasive scalp biopsies and guides early psychological support and hair-restoration planning. Always correlate genetic results with a complete dermatological examination; no single gene test can replace clinical judgement.”

— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403

Advisory Guidance for Patients and Clinicians

This test is designed exclusively for inherited hypotrichosis evaluation. It is not indicated for acute or temporary hair loss conditions such as telogen effluvium, alopecia areata, or chemotherapy-induced alopecia. Patients should continue all prescribed treatments, including topical or oral therapies, until explicitly advised otherwise by their managing physician. The test must always be accompanied by pre-test genetic counselling to ensure informed decision-making.

Exclusion Criteria & Urgent Referral Indicators

This test is not intended for emergency assessment of sudden or rapid hair loss.
Do not discontinue any prescribed medication (e.g., minoxidil, finasteride, or immunosuppressants) before consulting your doctor.
If hair loss is accompanied by severe scalp pain, purulent discharge, or systemic symptoms such as fever or joint pain, seek immediate dermatological emergency care.
Genetic testing in minors requires informed parental consent accompanied by formal pre-test genetic counselling as mandated by Federal Decree-Law No. 4 of 2016 on Medical Liability.

Patient FAQ & Clinical Guidance

1. What is the difference between this NGS test and a routine hair loss blood panel?

This NGS analysis sequences every exon of the HR gene at 500x depth, achieving >99.9% sensitivity for point mutations, small insertions and deletions, and copy-number variants. Routine hair loss panels typically test only a few common SNPs and miss up to 15% of causative HR gene variants.

2. Can I submit a previously collected DNA sample or must I provide fresh blood?

You may provide 2 mL of EDTA whole blood (gold standard), a dried blood spot on an FTA card, or previously extracted DNA (minimum 200 ng) stored at -80°C. The laboratory will verify sample integrity before processing to guarantee reliable results. Home collection is available daily from 8 AM to 11 PM via our temperature-controlled courier service.

3. What support is provided after I receive the genetic report?

Within seven working days of report delivery, a DHA-licensed consultant medical geneticist will contact you for a complimentary 15-minute tele-consultation. This session covers variant classification, recurrence risk assessment, and connection to UAE-based patient support networks for inherited hair loss conditions.

4. How long does it take to get the results, and how are they delivered?

The standard turnaround time is 3–4 weeks from sample receipt. Results are delivered electronically via a secure patient portal and a printed hard copy sent to your registered address. Both versions include the full ACMG variant classification, clinical interpretation, and recommendations for follow-up.

UAE Regulatory & Data Privacy Adherence

DNA Labs UAE operates under DHA Facility License Number 1143 and strictly complies with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) for all genetic data processing, storage, and transmission. All clinical health information is handled in accordance with Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Patient safety and informed consent protocols adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability. Genetic test results are encrypted, access-controlled, and never shared with third parties without explicit written patient consent.

Clinical & Logistical Metadata

Test Name	HR Gene Hypotrichosis Type 4 Genetic Test (NGS)
Price (AED)	2,800
Turnaround Time	3–4 weeks
Sample Type / Matrix	Whole blood (EDTA), FTA card, or extracted DNA (≥200 ng)
Methodology Used	Next-Generation Sequencing (NGS) on Illumina NovaSeq with CNV calling
ICD-10-CM Code	Q84.0 (Congenital alopecia)
LOINC Code	87710-3 (HR gene mutation analysis in blood or tissue)
DHA Facility License & Laboratory Address	License 1143 – Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE – DNA Labs UAE