APCDD1 Gene Hypotrichosis Type 1 Genetic Test in UAE | 2,800 AED | DHA Licensed & ISO 9001:2015

Executive Summary & Core Metrics

This next-generation sequencing test provides definitive genetic diagnosis for hereditary hypotrichosis simplex type 1 through comprehensive analysis of the APCDD1 gene.

✓ Accuracy Guarantee: 99.9% diagnostic sensitivity via ISO 9001:2015 accredited NGS processing.

✓ Premium Logistics: VIP Mobile Phlebotomy & temperature-controlled cold-chain home collection available daily 8 AM – 11 PM.

✓ Clinical Guidance: Telephonic post-test consultation by DHA-licensed genetic counsellors for personalised result interpretation.

✓ Insurance: Direct billing verification – WhatsApp +971 54 548 8731.

Test Overview & Methodology

The APCDD1 gene test identifies pathogenic mutations linked to autosomal dominant hypotrichosis simplex using next-generation sequencing (Illumina platform). It provides full gene coverage with copy-number variant detection, delivering a precise genetic diagnosis for patients presenting with sparse or absent scalp hair from early childhood.

Feature	Our APCDD1 NGS Test	Single-Gene Sanger Sequencing
Precision & Coverage	Full gene sequencing with CNV detection (99.9% analytical sensitivity)	Only targeted point mutations; limited CNV detection
Methodology	Next-Generation Sequencing (Illumina, validated per CAP/CLIA standards)	Capillary electrophoresis-based Sanger sequencing
Turnaround Time	3 – 4 Weeks with comprehensive clinical report	6 – 8 Weeks; limited variant interpretation

Indicated Clinical Specialties: Clinical Geneticist (genetic counselling, pedigree analysis, result interpretation), Consultant Medical Genetics (advanced variant annotation, inheritance risk assessment), Dermatologist (clinical correlation & hair disorder management).

Physician Insight & Safety Protocols

“A genetic diagnosis is never a standalone endpoint. The APCDD1 test must be interpreted in the context of a three-generation pedigree and thorough dermatological evaluation. Even a clearly pathogenic mutation can exhibit variable expressivity, so clinical correlation is essential before treatment decisions. Our integrated counselling ensures families understand recurrence risks and available management options.”

— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403

Advisory: Medication & Treatment Considerations

Important: Do not discontinue any prescribed hair loss or dermatological medications without consulting your treating physician. The genetic test result is a diagnostic aid, not a treatment order. Any therapeutic adjustments must be supervised by a qualified specialist.

Exclusion Criteria & Emergency Red Flags

Active febrile illness or systemic infection within 72 hours of sample collection.
Inability to provide informed consent or cooperate with blood draw / FTA card collection.
Known severe adverse reaction to phlebotomy (e.g., vasovagal syncope with injury risk) — pre-sedation not provided.
Seek immediate medical attention if you experience dizziness, fainting, rapid swelling at the puncture site, or shortness of breath after collection.

Patient FAQ & Clinical Guidance

1. What is this APCDD1 gene test used for?

This NGS test analyzes the APCDD1 gene to detect mutations causing hereditary hypotrichosis simplex type 1, a rare form of hair loss that typically begins in early childhood. It is indicated for individuals with sparse or absent scalp hair, those with a positive family history of the condition, and for carrier testing in at-risk relatives. The report identifies pathogenic variants and clarifies autosomal dominant inheritance risk.

2. How is the sample collected? Is a needle required?

Sample collection is performed by a certified phlebotomist and can be done via a simple blood draw (3–5 mL from a vein) or a painless finger prick for an FTA card (a single drop of blood on absorbent paper). Both methods are sufficient for DNA extraction and are particularly convenient for paediatric patients. VIP Mobile Phlebotomy home collection is available daily from 8 AM to 11 PM.

3. How long do results take and what will the report include?

Results are delivered within 3 to 4 weeks. The comprehensive report includes the identified variant (with HGVS nomenclature), pathogenicity classification per ACMG criteria, and a correlated risk assessment. Telephonic post-test counselling by a DHA-licensed genetic counsellor is included to explain findings and recommend further steps (e.g., dermatology referral, family testing).

UAE Regulatory & Data Privacy Adherence

Your genetic data is protected under the highest UAE standards.

Licensed under DHA Facility Permit 1143 – Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE.
Compliant with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) – all genetic data is encrypted, stored securely, and never shared without explicit consent.
Adheres to Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields for electronic health records and telemedicine.
Clinical safety and patient consent governed by Federal Decree-Law No. 4 of 2016 on Medical Liability.
Accredited to ISO 9001:2015 (Cert: INT/EGQ/2509DA/3139) for laboratory quality management systems.

Clinical & Logistical Metadata

Test Name	APCDD1 Gene Hypotrichosis Type 1 Genetic Test (NGS)
Price (AED)	2,800 AED
Turnaround Time	3 – 4 Weeks
Sample Type / Matrix	Peripheral whole blood (3–5 mL) or dried blood spot on FTA card
Methodology Used	Next-Generation Sequencing (Illumina) with CNV analysis
ICD-10-CM Code	Q84.0 (Congenital alopecia)
LOINC Code	94027-0 (APCDD1 gene mutations identified in Blood or Tissue by Sequencing)
DHA Facility License & Laboratory Address	License: 1143 – Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE (DNA Labs UAE)