Test Price
2,800 AED✅ Home Collection Available
GJB2 Gene (Connexin 26) Deafness with Keratopachydermia & Digital Constrictions Genetic Test in UAE | 2800 AED
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO Accredited NGS Processing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection, available daily from 8 AM to 11 PM.
- Clinical Guidance: Post-Test Genetic Counseling by a DHA-licensed Consultant Medical Genetics (Dr. Lina Quteineh).
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
This advanced Next-Generation Sequencing test provides full gene coverage of the GJB2 gene (Connexin 26), including deep intronic and regulatory regions, for definitive diagnosis of syndromic hearing loss with palmoplantar keratoderma and digital constrictions (Vohwinkel syndrome). The analysis is performed at DNA Labs UAE, an ISO 9001:2015 accredited facility under DHA license no. 1143.
| Feature | Our Test (NGS) | Closest Alternative (Sanger) |
|---|---|---|
| Precision | Full gene, including deep intronic & regulatory regions | Targeted exons only |
| Methodology | Next‑Generation Sequencing (Illumina® platform) | Sanger sequencing |
| Turnaround Time | 3–4 Weeks | 6–8 Weeks |
| Diagnostic Yield | >99% (variant detection) | ~85% |
| Price | 2800 AED | ~2400 AED |
Physician Insight & Safety Protocols
From the desk of Lina Osama Zaki Quteineh, Consultant Medical Genetics | DHA Registration ID: 9294403:
“A positive GJB2 variant must be correlated with detailed clinical phenotype and pedigree analysis. Genetic diagnosis empowers families but never replaces compassionate care. I strongly recommend post-test genetic counseling to discuss inheritance patterns and reproductive options. Remember, this test alone does not dictate treatment withdrawal or initiation.”
Medication Advisory
⚠️ Medication Warning
Do not discontinue any prescribed medication (e.g., hearing aids, dermatological treatments) based solely on this genetic result without consulting your doctor.
Exclusion Criteria & Emergency Red Flags
- Inability to give informed consent – mandatory pre-test genetic counseling required.
- Active febrile illness or acute infection – postpone non-urgent phlebotomy.
- Severe coagulopathy (e.g., INR >3.0) – only saliva sample or extracted DNA accepted.
- Red Flags: Sudden progressive hearing loss with neurological symptoms – urgent ENT/neurology referral needed.
Patient FAQ & Clinical Guidance
1. What is the diagnostic accuracy of this GJB2 NGS test for syndromic hearing loss?
This GJB2 NGS delivers a diagnostic yield exceeding 99% for detecting pathogenic variants in syndromic hearing loss with keratoderma and digital anomalies. The analysis is performed using ISO‑accredited deep sequencing at DNA Labs UAE, a DHA-licensed facility.
2. How long do results take and what does the report include?
Results are delivered within 3‑4 weeks. The comprehensive report includes variant classification (pathogenic, likely pathogenic, VUS), clinical interpretation, and genetic counseling recommendations ready for your physician.
3. Is home blood collection available in Dubai and Abu Dhabi?
Yes, we offer VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection across all Emirates including Dubai, Abu Dhabi, and Sharjah from 8 AM to 11 PM daily.
UAE Regulatory & Data Privacy Adherence
🇦🇪 Compliance Framework
This service adheres to Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical safety and consent are governed by Federal Decree-Law No. 4 of 2016 on Medical Liability. Genetic data is processed exclusively within UAE-sovereign servers. ISO 9001:2015 Certified (Cert: INT/EGQ/2509DA/3139).
Clinical & Logistical Metadata
| Test Name | GJB2 Gene (Connexin 26) Deafness with Keratopachydermia & Digital Constrictions Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Peripheral Whole Blood (3–5 mL in EDTA tube) or Saliva (Oragene DNA kit) – VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM. |
| Methodology Used | Next-Generation Sequencing (Illumina® platform) – Full gene sequencing including deep intronic and regulatory regions |
| ICD-10-CM Code | Q87.8, H90.5 |
| LOINC Code | 92946-7 |
| DHA Facility License & Laboratory Address | Facility License No: 1143 | DNA Labs UAE, Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians