Test Price
2,800 AED✅ Home Collection Available
TBC1D24 Gene Deafness, Autosomal Recessive Type 86 Genetic Test in UAE | 2,800 AED | DNA Labs UAE
Executive Summary & Core Metrics
The TBC1D24 genetic test delivers 99.9% diagnostic sensitivity for detecting pathogenic variants causing autosomal recessive nonsyndromic hearing loss type 86 (DFNB86). Performed at DNA Labs UAE under ISO-accredited processes, this test includes VIP mobile phlebotomy with temperature-controlled cold-chain logistics, post-test telephonic clinical guidance, and direct insurance billing verification via WhatsApp +971 54 548 8731.
- Diagnostic Accuracy: 99.9% sensitivity > 99% specificity via NGS with Sanger confirmation.
- Collection Model: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (daily 8 AM – 11 PM).
- Clinical Support: Telephonic post-test result interpretation by a Consultant Medical Genetics.
- Pricing: 2,800 AED inclusive of collection, processing, and counseling.
- Insurance: Direct billing verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
This molecular assay sequences the entire TBC1D24 coding region, splice sites, and exon‑intron boundaries using next‑generation sequencing (NGS) on an Illumina platform with >100× mean depth. All reported variants are confirmed by orthogonal Sanger sequencing. The test enables definitive diagnosis of DFNB86, distinguishes it from other hereditary hearing loss syndromes, and informs genetic counseling and family planning.
| Feature | TBC1D24 Test (NGS) | Alternative (Single‑Gene Sanger) |
|---|---|---|
| Methodology | NGS whole‑gene sequencing + Sanger confirmation | Sanger sequencing of known hot‑spot variants only |
| Detection Scope | All coding exons, splice sites, and novel variants | Pre‑specified mutations only |
| Turnaround Time | 3–4 weeks | 6–8 weeks |
| Cost (AED) | 2,800 | ≥ 3,500 |
Physician Insight & Safety Protocols
“As a Consultant Medical Genetics, I recognize the emotional weight of pursuing a hearing‑loss genetic diagnosis. The TBC1D24 test provides critical clarity, yet results must always be interpreted within your full clinical context, family pedigree, and specialist evaluation. No single laboratory finding replaces comprehensive medical judgment or genetic counseling.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics | DHA Registration ID: 9294403
Advisory & Precautions
⚠️ Medication Notice
Do not discontinue any prescribed medication or alter your treatment plan without direct consultation with your treating physician. This genetic test does not replace ongoing clinical management.
Exclusion Criteria & Emergency Red Flags
Contraindications for Testing
- Active febrile illness or systemic infection – postpone collection until fully resolved.
- Sample degradation risk (e.g., repeated freeze‑thaw of extracted DNA).
- Inability to provide informed consent; minors must be represented by a legal guardian as per Federal Decree-Law No. 4 of 2016 on Medical Liability.
- Seek immediate emergency care if you experience: sudden profound hearing loss, acute vertigo, or new‑onset tinnitus.
Patient FAQ & Clinical Guidance
1. What is the TBC1D24 gene test used for?
This genetic test identifies disease‑causing mutations in the TBC1D24 gene, confirming a molecular diagnosis of autosomal recessive deafness type 86 (DFNB86) and differentiating it from other hereditary hearing loss syndromes. The result guides prognosis, family screening, and reproductive options.
2. How accurate is the NGS testing methodology?
Our NGS assay achieves over 99% analytical sensitivity and specificity through high‑depth sequencing (≥100×), proprietary bioinformatics pipelines, and confirmatory Sanger sequencing of all clinically reported variants. This dual‑approach minimizes false positives and false negatives.
3. Do I need a doctor’s referral for this test?
A referral from an ENT specialist or clinical geneticist is strongly recommended to ensure proper clinical correlation, pre‑ and post‑test genetic counseling, and integration of results with your family history and audiologic profile.
4. Can the test be performed during pregnancy?
Yes, if clinically indicated and after informed consent, the test can be performed on the proband or carrier parents. Prenatal diagnosis requires prior specialist consultation and coordination with a fetal medicine unit.
UAE Regulatory & Data Privacy Adherence
Your Data. Your Rights. Our Commitment.
DNA Labs UAE operates under DHA Facility License No. 1143 and complies with all applicable UAE federal laws governing personal health data and medical testing:
- Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) – governs the collection, processing, and storage of your personal data.
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields – regulates digital health records and telemedicine practices.
- Federal Decree-Law No. 4 of 2016 on Medical Liability – ensures informed consent, patient safety, and professional accountability.
Your genetic data is encrypted, access‑controlled, and never shared with third parties without your explicit written consent. We maintain ISO 27001‑aligned information security practices.
Clinical & Logistical Metadata
| Test Name | TBC1D24 Gene Deafness, Autosomal Recessive Type 86 (DFNB86) Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 weeks (21–28 business days) |
| Sample Type / Matrix | Peripheral Whole Blood (EDTA) — VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (daily 8 AM – 11 PM) |
| Methodology Used | Next‑Generation Sequencing (NGS) with Sanger Confirmation |
| ICD-10-CM Code | H90.3 (Sensorineural hearing loss, bilateral) — primary; Z13.71 (Encounter for genetic testing) — associated |
| LOINC Code | 82236-1 (Hearing loss genetic test) |
| DHA Facility License & Laboratory Address | License No. 1143 — Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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