Test Price
2,800 AEDโ Home Collection Available
CRYM Gene Deafness, Autosomal Dominant Type 40 Genetic Test in UAE | 2800 AED | DHA Certified
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO Accredited Processing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection. Available daily from 8 AM to 11 PM.
- Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The CRYM genetic test uses advanced Next-Generation Sequencing (NGS) to identify pathogenic variants in the CRYM gene responsible for autosomal dominant non-syndromic hearing loss (DFNA40). This comprehensive analysis covers all coding exons and adjacent splice sites, delivering clinically actionable results for families affected by hereditary deafness.
| Feature | Our Test (CRYM NGS) | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Precision | >99.9% Analytical Sensitivity & Specificity | ~99% for targeted regions |
| Method | Next-Generation Sequencing (NGS) | Chain-termination (Sanger) sequencing |
| Speed | 3โ4 Weeks | 6โ8 Weeks |
| Gene Coverage | Full coding region + splice sites | Limited to a few exons |
Physician Insight & Safety Protocols
โ Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Clinical Advisory
Important: Genetic test results should not replace immediate clinical evaluation. Always consult your physician for comprehensive management of hearing loss. Do not modify or discontinue any prescribed treatment based solely on genetic findings without specialist guidance.
Safety Exclusion Criteria
- Recent blood transfusion (within 3 weeks) or allogeneic bone marrow transplant: May interfere with DNA analysis.
- Emergency symptoms: Sudden total hearing loss accompanied by severe vertigo, facial weakness, or acute tinnitus - proceed to nearest emergency department immediately.
- Pediatric considerations: Not recommended for neonatal screening without clinical indication; consent from legal guardian required.
Patient FAQ & Clinical Guidance
1. What is the CRYM gene and its role in hearing loss?
CRYM gene encodes ยต-crystallin essential for cochlear health; mutations cause autosomal dominant deafness type 40. This protein regulates thyroid hormone availability in the inner ear, and its disruption leads to progressive sensorineural hearing loss often appearing in adulthood.
2. How accurate is the NGS CRYM gene test?
NGS provides >99.9% sensitivity and specificity for CRYM variants, validated by ISO 9001:2015 standards. Every sequence variant is confirmed by orthogonal methods and interpreted according to ACMG guidelines to ensure clinical reliability.
3. What does a positive result mean for my family?
Positive CRYM result confirms hereditary deafness with 50% inheritance risk per child; genetic counseling essential. Family members can opt for cascade testing, and the information aids in early intervention and informed reproductive choices.
UAE Regulatory & Data Privacy Adherence
Regulatory Compliance:
- Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL).
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
- Federal Decree-Law No. 4 of 2016 on Medical Liability.
- DHA Facility License No: 1143.
- DNA Labs UAE โ ISO 9001:2015 Certified (Cert: INT/EGQ/2509DA/3139).
Clinical & Logistical Metadata
| Test Name | CRYM Gene Deafness, Autosomal Dominant Type 40 Genetic Test |
| Price (AED) | 2,800 |
| Turnaround Time | 3โ4 Weeks |
| Sample Type / Matrix | Peripheral Whole Blood (EDTA) |
| Methodology Used | Next-Generation Sequencing (NGS) โ Full coding exons and splice sites |
| ICD-10-CM Code | H90.3 (Sensorineural hearing loss, bilateral) |
| LOINC Code | 81408-0 (Hereditary hearing and deafness panel) |
| DHA Facility License & Laboratory Address | DHA License No: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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