Test Price
2,800 AED✅ Home Collection Available
COL4A6 Gene Deafness, X‑Linked Type 6 Genetic Test in UAE | 2800 AED
Executive Summary & Core Metrics
Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing (Cert: INT/EGQ/2509DA/3139).
Premium Logistics: VIP Mobile Phlebotomy & Temperature‑Controlled Cold‑Chain Home Collection available daily from 8 AM to 11 PM.
Clinical Guidance: Complimentary telephonic post‑test clinical guidance for result interpretation by DHA‑licensed genetic experts.
Insurance: Direct billing verification via WhatsApp at +971 54 548 8731.
CPT Code: 81407
Test Overview & Methodology
This test utilizes Next‑Generation Sequencing (NGS) to analyze the coding regions and splice sites of the COL4A6 gene, identifying pathogenic variants responsible for X‑linked deafness type 6. This non‑syndromic hearing loss predominantly affects males; carrier detection in females is critical for informed reproductive planning and early intervention. The assay includes copy number variation (CNV) analysis via a robust bioinformatic pipeline.
| Feature | Our Test (DNA Labs UAE) | Closest Alternative |
|---|---|---|
| Precision | Full gene NGS with CNV analysis via robust bioinformatic pipelines. | May not include CNV analysis; limited to point mutations. |
| Methodology | NGS with Long‑Range PCR for coverage of GC‑rich and homologous regions. | Standard short‑read NGS, potential for allelic dropout. |
| Speed | 3 to 4 Weeks | 4 to 6 Weeks |
Physician Insight & Safety Protocols
"As a clinical geneticist, I recognize that pursuing a genetic diagnosis for hearing loss carries profound implications for families. This test is a powerful diagnostic tool, but results must be carefully interpreted alongside audiometric evaluation and a three‑generation family pedigree. My commitment is to provide compassionate, evidence‑based guidance so that you and your family can make informed decisions about management and future planning."
— Lina Osama Zaki Quteineh, Consultant Medical Genetics | DHA Registration ID: 9294403
Medication Warning
Do not discontinue prescribed medication without consulting your doctor.
Exclusion Criteria & ER Red Flags
- Absolute Exclusion: Inability to provide a valid DHA/MOHAP‑authorized request form from an ENT specialist, clinical geneticist, or relevant qualified physician. Parental consent is mandatory for minors in accordance with Federal Decree‑Law No. 4 of 2016 on Medical Liability.
- Exclusion: Recent (less than 4 weeks) allogeneic blood transfusion or bone marrow transplant, as the sample would reflect donor DNA.
- Emergency Red Flag: This test is for diagnostic and prognostic purposes, not for acute management. If a patient presents with sudden sensorineural hearing loss (SSNHL), this is a medical emergency—proceed immediately to the nearest emergency department.
Patient FAQ & Clinical Guidance
1. What is the diagnostic yield of the COL4A6 gene test for X‑linked deafness?
This NGS assay provides a definitive molecular diagnosis by identifying pathogenic variants in the COL4A6 gene. Combined with clinical audiometry, it offers exceptionally high analytical sensitivity and specificity. A positive result confirms the genetic etiology of non‑syndromic X‑linked hearing loss, enabling targeted clinical management and accurate genetic counseling for at‑risk family members.
2. Does this test detect all causes of hereditary hearing loss?
No, this test is specifically designed to analyze the COL4A6 gene associated with X‑linked deafness type 6. If the result is negative, your physician may recommend a broader gene panel for hearing loss to evaluate additional genes. A comprehensive genetic counseling session is required to map a detailed pedigree and document full clinical history before testing.
3. What are the sample requirements and is home collection available?
A blood sample (peripheral whole blood in EDTA), extracted DNA, or a single dried blood spot on an FTA card is acceptable. VIP Mobile Phlebotomy and temperature‑controlled cold‑chain home collection are available daily from 8 AM to 11 PM. Do not discontinue any medication without consulting your doctor prior to collection.
UAE Regulatory & Data Privacy Adherence
This genetic test is performed in full compliance with UAE federal data protection and healthcare regulations. All personal data is processed and stored in accordance with Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical safety and patient consent protocols strictly follow Federal Decree‑Law No. 4 of 2016 on Medical Liability. Patient results are only disclosed to the ordering physician and authorized recipients with explicit consent.
Clinical & Logistical Metadata
| Test Name | COL4A6 Gene Deafness, X‑Linked Type 6 (NGS Sequencing) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 weeks (from sample receipt) |
| Sample Type / Matrix | Peripheral whole blood (EDTA), extracted DNA, or dried blood spot (FTA card). VIP Mobile Phlebotomy & Temperature‑Controlled Cold‑Chain Home Collection available (8 AM–11 PM daily). |
| Methodology Used | Next‑Generation Sequencing (NGS) with Long‑Range PCR and CNV analysis |
| ICD‑10‑CM Code | Q80.9 (Congenital deafness, unspecified) |
| LOINC Code | 82812-2 (COL4A6 gene sequencing) |
| DHA Facility License & Laboratory Address | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE — DHA License: 1143 |
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