Test Price
2,800 AED✅ Home Collection Available
HBB Gene Sickle Cell Anemia Next-Generation Sequencing (NGS) Genetic Test
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% diagnostic sensitivity via ISO 15189 accredited next-generation sequencing.
- Premium Logistics: VIP mobile phlebotomy & temperature-controlled cold-chain home collection available daily from 8 AM to 11 PM.
- Clinical Guidance: Telephonic post-test interpretation and genetic counseling included with every result.
- Insurance: Direct billing verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
This test employs Next-Generation Sequencing to analyze the complete coding region of the HBB gene, detecting all clinically relevant mutations associated with sickle cell disease and trait with unparalleled precision. It is the most conclusive genetic investigation recommended by hematologists for diagnosis, carrier screening, and pre-transplant evaluation.
| Feature | Our Test (NGS) | Standard Hemoglobin Electrophoresis |
|---|---|---|
| Methodology | Full HBB Gene Sequencing (NGS) | Protein-Based Migration |
| Mutation Detection | All Known Pathogenic Variants (SNVs, INdels) | HbS and a Few Common Variants |
| Turnaround Time | 3–4 Weeks | 5–7 Days |
| Clinical Utility | Comprehensive Diagnostic & Carrier Screening | Screening in Crisis; Limited Scope |
Physician Insight & Safety Protocols
“As a consultant medical geneticist, I have seen how comprehensive HBB gene sequencing transforms diagnostic accuracy. This NGS test provides definitive answers for sickle cell disease and carrier status. However, results must always be interpreted alongside a complete clinical history and family pedigree. Our post-test genetic counseling session ensures you fully understand the implications for your health and family planning.”
— Lina Osama Zaki Quteineh | Consultant Medical Genetics | DHA Registration ID: 9294403
Pre-Test Genetic Counseling Advisory
A mandatory genetic counseling session with a qualified genetic counselor is required prior to sample collection. During this session, a detailed family pedigree chart will be drawn to document HBB-related phenotypes among relatives. This ensures proper interpretation of results and informs the testing strategy. Sample can be collected as whole blood, extracted DNA, or one drop of blood on an FTA card.
Safety Exclusion Criteria & Emergency Red Flags
- This test is not suitable for acute medical emergencies; if you are experiencing severe pain, fever, or signs of stroke, seek immediate ER care.
- Home collection is contraindicated in hemodynamically unstable patients.
- Red flags requiring immediate medical attention: sudden chest pain, difficulty breathing, severe headache, limb weakness, priapism, or altered consciousness.
- Genetic results may reveal carrier status with psychological implications – pre-test counseling is essential.
- Not a substitute for a face-to-face hematology consultation.
Patient FAQ & Clinical Guidance
1. What is the HBB Gene Sickle Cell Anemia Genetic Test, and why is it ordered?
This advanced genetic test sequences the entire HBB gene to identify sickle cell disease-causing mutations with 99.9% accuracy. It is ordered by hematologists, oncologists, or medical researchers when clinical signs suggest hemoglobinopathy, for carrier screening, or for pre-treatment evaluation. The full gene analysis eliminates diagnostic ambiguity associated with traditional protein-based tests.
2. Is home blood collection safe and how does it work?
Our DHA-licensed phlebotomists use ISO-certified cold-chain transport to ensure sample stability from your doorstep to the lab. Appointment scheduling is available between 8 AM and 11 PM via WhatsApp. The collector arrives with full PPE, verifies identity, and follows strict aseptic protocols. Your sample is immediately transferred into temperature-controlled containers, guaranteeing no degradation.
3. How long do results take, and who interprets them?
Results are returned within 3–4 weeks, accompanied by a clinical guidance session via teleconsultation with a geneticist. A comprehensive report detailing all detected variants and their clinical significance is provided. Your managing physician or our consulting medical geneticist will explain the implications for your health and family planning, ensuring you never face confusion alone.
UAE Regulatory & Data Privacy Adherence
Data Protection & Health Information Security
This laboratory and all associated data handling processes strictly comply with:
- Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL)
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields
- Federal Decree-Law No. 4 of 2016 on Medical Liability
Your clinical information is encrypted, access-controlled, and never shared without explicit consent. All genetic testing adheres to DHA standards for genetic testing and counseling.
Clinical & Logistical Metadata
| Test Name | HBB Gene Sickle Cell Anemia Next-Generation Sequencing (NGS) Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Whole Blood (EDTA), Extracted DNA, or FTA Card |
| Methodology Used | Next-Generation Sequencing (NGS) – Full HBB Gene Sequencing |
| ICD-10-CM Code | D57.1 (Sickle-cell disease without crisis), Z13.0 (Carrier screening) |
| LOINC Code | 82916-7 (HBB gene mutations detected in Blood or Tissue by Molecular genetics method) |
| DHA Facility License & Laboratory Address | License: 1143 Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE Corporate Lab: DNA Labs UAE |
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