Test Price
800 AED✅ Home Collection Available
Hereditary Persistence of Fetal Hemoglobin (HPFH) Genetic Test in UAE | DNA Labs UAE
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 15189‑accredited End Point PCR methodology.
- Logistics Framework: Hospital Extraction Only – Sample collection is conducted strictly within an accredited hospital facility; mobile home phlebotomy is disabled for safety.
- Clinical Guidance: DHA‑licensed Consultant Medical Genetics provides post‑test result interpretation via telephonic consultation.
- Insurance: Direct Billing Verification via WhatsApp: +971 54 548 8731.
Test Overview & Methodology
Hereditary Persistence of Fetal Hemoglobin (HPFH) is a benign genetic condition characterized by continued gamma‑globin expression in adulthood, resulting in persistently elevated HbF levels. This molecular test employs End Point PCR to detect the specific large‑scale deletions or point mutations within the beta‑globin gene cluster that cause HPFH. Precise genotyping enables definitive differentiation from clinically significant hemoglobinopathies such as delta‑beta thalassemia and sickle cell disease, thereby guiding appropriate patient management and family planning decisions.
| Feature | DNA Labs UAE HPFH Molecular Test | Standard Hb Electrophoresis / HPLC |
|---|---|---|
| Method | End Point PCR (DNA‑based) | Protein separation / Hb fraction quantification |
| Precision | 99.9% specificity for HPFH‑causing mutations | Quantifies % HbF but cannot distinguish genetic HPFH from other causes of elevated HbF |
| Turnaround | 7–8 Business Days | 1–2 Days |
| Sample Types | Amniotic fluid, Chorionic villi, Cord blood | Peripheral venous blood |
Physician Insight & Safety Protocols
“HPFH is a clinically silent and benign condition that does not require therapeutic intervention. However, confirmatory molecular genotyping is essential for accurate genetic counselling and to distinguish this entity from thalassemia syndromes that carry significant clinical implications. Always interpret results within the full hematological and clinical context.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory: Medication Continuity
Do not discontinue or alter any prescribed medication or therapy without prior consultation with your treating physician.
Exclusion Criteria & Emergency Red Flags
- Peripheral blood analysis is not reliable within 4 weeks after a recent blood transfusion (prenatal samples are unaffected).
- Invasive fetal sampling (amniocentesis, CVS) is contraindicated in the presence of active vaginal bleeding, untreated maternal infection, severe coagulation disorders, or placental abnormalities.
- The procedure carries a small miscarriage risk (approximately 1/200 to 1/500); this test must only proceed under specialist supervision.
- Seek emergency medical attention immediately if you experience severe abdominal pain, heavy vaginal bleeding, fever above 38°C, or leakage of amniotic fluid after CVS or amniocentesis.
Patient FAQ & Clinical Guidance
1. What is HPFH and when is this molecular test recommended?
HPFH is a benign genetic condition that causes persistently elevated fetal hemoglobin levels after birth. This molecular test is recommended when routine hemoglobin electrophoresis or HPLC shows unexplained high HbF, to definitively distinguish HPFH from delta‑beta thalassemia or other hemoglobin disorders. It is also indicated for prenatal diagnosis in families with known beta‑globin cluster mutations.
2. How is the sample collected and is it safe during pregnancy?
Sample collection is performed exclusively within an accredited hospital setting. For prenatal cases, a specialist‑guided amniocentesis or chorionic villus sampling (CVS) is used. For neonatal confirmation, cord blood is collected at delivery. All procedures follow strict sterile protocols with accepted procedural risks; the decision to proceed must involve a multidisciplinary team.
3. How long for results and what do they mean?
Results are reported within 7–8 business days. A positive result confirms the presence of a specific HPFH‑associated deletion or point mutation, indicating a benign condition that generally requires no medical treatment. A negative result does not rule out other causes of elevated HbF, and your genetic counsellor or physician will correlate the finding with your complete clinical profile.
4. Can this test be done after a blood transfusion?
Peripheral blood sampling is not reliable within four weeks following a blood transfusion due to dilution of the patient's own red cells. However, prenatal specimens (amniotic fluid, chorionic villi) are unaffected by maternal transfusion history and remain valid for molecular analysis.
5. Will my insurance cover this genetic test?
Coverage depends on your individual insurance plan and policy terms. DNA Labs UAE offers direct billing verification; contact us via WhatsApp at +971 54 548 8731 to check your eligibility and obtain a pre‑authorization quote before scheduling the procedure.
UAE Regulatory & Data Privacy Adherence
This genetic testing service operates in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All patient genomic data is encrypted, access‑controlled, and processed solely for diagnostic purposes with documented informed consent. Clinical safety and patient consent protocols adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability. The laboratory is ISO 9001:2015 certified (INT/EGQ/2509DA/3139) and holds DHA Facility License No. 1143.
Clinical & Logistical Metadata
| Test Name | Hereditary Persistence of Fetal Hemoglobin (HPFH) Genetic Test |
| Price (AED) | 800 |
| Turnaround Time | 7–8 Business Days |
| Sample Type / Matrix | Amniotic Fluid, Chorionic Villi, Cord Blood Hospital Extraction Only – Sample collection is conducted strictly within an accredited hospital facility; mobile home phlebotomy is disabled for safety. |
| Methodology Used | End Point PCR |
| ICD-10-CM Code | D56.4 |
| LOINC Code | 50542-7 |
| DHA Facility License & Laboratory Address | License No. 1143 — Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE Corporate Lab Branding: DNA Labs UAE |
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