Test Price
2,800 AED✅ Home Collection Available
TFR2 Gene Hemochromatosis Type 3 Genetic Test in UAE | 2800 AED | DHA Licensed
Executive Summary & Core Metrics
Definitive NGS Analysis for Hereditary Hemochromatosis Type 3
This definitive genetic test leverages Next-Generation Sequencing (NGS) to analyse the entire TFR2 gene for pathogenic variants linked to type 3 hereditary hemochromatosis – a condition causing severe iron overload. With 99.9% diagnostic sensitivity under ISO 9001:2015 accredited processing (Cert. INT/EGQ/2509DA/3139), it enables early intervention and prevents multi-organ damage. Delivery: VIP mobile phlebotomy & temperature-controlled cold-chain home collection (8 AM–11 PM), ISO-certified logistics, and telephonic post-test clinical guidance included. Direct insurance billing verification via WhatsApp: +971 54 548 8731.
Test Overview & Methodology
Comprehensive NGS Sequencing for TFR2-Related Hemochromatosis
This test sequences the entire coding region of the TFR2 gene to detect point mutations, small insertions/deletions, and copy number variants known to cause type 3 hereditary hemochromatosis. Unlike limited mutation panels, our NGS approach guarantees greater than 99.9% analytical sensitivity and covers emerging variants, giving clinicians and at-risk family members unequivocal diagnostic clarity.
| Feature | Our TFR2 NGS Test | Closest Alternative |
|---|---|---|
| Methodology | Next-Generation Sequencing (Illumina platform) – full gene and CNV analysis | Targeted Mutation Panel (PCR + Sanger confirmation) |
| Analytical Sensitivity | 99.9% (detects over 99% of pathogenic TFR2 variants) | Approximately 85% (limited to pre-specified mutations) |
| Turnaround Time | 3 – 4 Weeks | 4 – 6 Weeks (typically) |
| Included Service | Pre-test genetic counselling, VIP mobile phlebotomy and cold-chain home collection, telephonic results guidance | Clinic visit only, limited post-test support |
| Regulatory Approval | DHA/MOHAP licensed, ISO 9001:2015, compliant with UAE PDPL and health data protection laws | Variable |
Physician Insight & Safety Protocols
“As a Consultant Medical Genetics, I emphasise that a TFR2 mutation report must be interpreted alongside serum ferritin, transferrin saturation, and liver function tests. A positive result indicates genetic susceptibility, not present disease; therefore, clinical correlation is mandatory. Patients should not discontinue any prescribed medication without consulting their doctor. Any worsening of fatigue, joint pain, or abdominal swelling warrants immediate medical review.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Medication Advisory & Safety Considerations
Important Safety Notice
Do not discontinue prescribed medication without consulting your doctor. Iron-chelating agents or therapeutic phlebotomy must be managed by a specialist.
- Exclusion Criteria: Active systemic infection, recent blood transfusion (less than 2 weeks), or current administration of iron chelation therapy may interfere with baseline iron markers and delay test scheduling. Please inform our genetic counsellor.
- Pregnancy and Minors: Genetic testing for minors requires written consent from a legal guardian per UAE Federal Decree-Law No. 4 of 2016 on Medical Liability. Pregnant women should discuss the necessity with their obstetrician.
- Emergency Red Flags: If you experience sudden severe abdominal pain, confusion, jaundice, persistent vomiting, or signs of heart failure (shortness of breath, swelling of legs) after learning a high-risk result, seek immediate emergency care.
Patient FAQ & Clinical Guidance
1. What is the TFR2 gene hemochromatosis type 3 test, and why is it ordered?
The TFR2 NGS test detects genetic mutations causing type 3 hemochromatosis for accurate diagnosis and early intervention. It is ordered when a patient presents with unexplained iron overload, has a family history of hereditary hemochromatosis, or for cascade screening of relatives. Early detection through this test allows timely management to prevent irreversible organ damage from iron accumulation.
2. How is the sample collected, and what is the process in the UAE?
A certified phlebotomist visits your home to draw one blood sample, which is shipped under temperature-controlled cold-chain to our Dubai laboratory. The entire process, including pre-test genetic counselling and results interpretation, is coordinated via WhatsApp (+971 54 548 8731), ensuring privacy and convenience under UAE PDPL. Home collection is available daily from 8 AM to 11 PM.
3. What happens if my TFR2 result is positive?
A positive TFR2 result confirms genetic susceptibility to type 3 hemochromatosis, prompting specialist referral for iron monitoring and possible phlebotomy treatment. It is not a cancer diagnosis but mandates lifelong surveillance. Our clinical team will explain the next steps and coordinate care with your DHA-licensed physician, ensuring a clear management pathway.
4. Is genetic counselling included with this test?
Yes, pre-test genetic counselling is provided to discuss the implications, benefits, and limitations of testing. Post-test, our consultant medical geneticist offers telephonic guidance to interpret results and recommend appropriate next steps, ensuring you fully understand your genetic status.
5. Can family members also be tested?
Yes, cascade screening of first-degree relatives is strongly recommended when a pathogenic TFR2 variant is identified. This allows at-risk family members to benefit from early intervention and surveillance, potentially preventing disease progression. Our team can coordinate testing for multiple family members with convenient home collection.
UAE Regulatory & Data Privacy Adherence
Healthcare Regulatory Assurance
This service is provided under DHA Facility License Number 1143 and strictly follows Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All genetic data is processed within the UAE and never shared without explicit patient consent. Clinical safety and patient consent protocols adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability. ISO 9001:2015 Certification (INT/EGQ/2509DA/3139) validates our quality management system.
Clinical & Logistical Metadata
| Test Name | TFR2 Gene Hemochromatosis Type 3 Genetic Test (NGS) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3 – 4 Weeks |
| Sample Type / Matrix | Peripheral whole blood (3–5 mL in EDTA tube) |
| Methodology Used | Next-Generation Sequencing (NGS) on Illumina platform, full gene coding region and CNV analysis |
| ICD-10-CM Code | E83.110 |
| LOINC Code | 94086-5 |
| DHA Facility License & Laboratory Address | License Number: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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