Test Price
2,800 AED✅ Home Collection Available
TBC1D24 Gene Autosomal Dominant Deafness Type 65 (DFNA65) Genetic Test in UAE | 2800 AED
Executive Summary & Core Metrics
Diagnostic Sensitivity: 99.9% via Targeted NGS with Sanger Validation
Turnaround Time: 3–4 Weeks (Local Processing)
Sample Type: Peripheral Whole Blood
Price: 2,800 AED (All Inclusive)
This targeted genetic test sequences the complete TBC1D24 gene to identify pathogenic variants causing autosomal dominant nonsyndromic hearing loss type DFNA65. Results are interpreted collaboratively by a Consultant Medical Geneticist and a Genetic Counselor, ensuring multidisciplinary diagnostic accuracy for hereditary hearing impairment.
Test Overview & Methodology
The TBC1D24 gene test employs next-generation sequencing (NGS) technology with orthogonal Sanger confirmation to detect single nucleotide variants, small insertions, and deletions across all coding exons and flanking intronic regions. This targeted approach achieves >99.9% diagnostic sensitivity specifically for DFNA65-associated alleles, enabling precise genetic counseling and proactive hearing management for affected families.
| Feature | Our Test (DNA Labs UAE) | Closest Alternative (Overseas Lab) |
|---|---|---|
| Methodology | Targeted NGS with Sanger validation | Whole Exome Sequencing (non-targeted) |
| Diagnostic Precision | >99.9% sensitivity for TBC1D24 variants | ~95% coverage; may miss deep intronic mutations |
| Turnaround Time | 3–4 Weeks (local processing) | 6–8 Weeks (international shipping) |
| Cost | 2,800 AED (all inclusive) | 3,500–5,000 AED + logistics |
Physician Insight & Safety Protocols
Lina Osama Zaki Quteineh | Consultant Medical Genetics | DHA Registration ID: 9294403
“Genetic hearing loss evaluation requires careful correlation of molecular findings with audiometric data and family history. The TBC1D24 gene analysis provides targeted diagnostic clarity for DFNA65, enabling informed family counseling and proactive hearing management. This test augments—not replaces—comprehensive otologic assessment by your ENT specialist.”
Medication & Clinical Advisory
Do not discontinue any prescribed medication, hearing aid, or therapeutic intervention without consulting your treating physician. Genetic testing is a diagnostic adjunct and does not alter acute medical therapy. If you are undergoing active chemotherapy, please schedule your blood collection at least two weeks after the last infusion to ensure optimal DNA quality.
Exclusion Criteria & Emergency Red Flags
- Exclusion: Severe anemia or medical contraindication to venipuncture—contact our nursing team for a buccal swab alternative.
- Exclusion: Active chemotherapy within the past two weeks may compromise DNA yield; please defer collection accordingly.
- Red Flag: Sudden onset unilateral hearing loss or vertigo requires immediate ENT emergency evaluation, not elective genetic testing.
- Red Flag: Presence of fever, active infection, or syncope prior to sample collection—reschedule your appointment.
Patient FAQ & Clinical Guidance
1. What does the TBC1D24 test detect and why is it called DFNA65?
This test identifies pathogenic variants in the TBC1D24 gene responsible for autosomal dominant deafness type 65, a progressive high-frequency hearing loss that typically begins in early adulthood. The DFNA65 designation follows the standardized nomenclature for autosomal dominant nonsyndromic hearing loss loci.
2. How should I prepare for the blood draw and do I need to stop any medications?
No special preparation is required—you may eat and drink normally before your appointment. Do not discontinue any prescription medications without explicit approval from your prescribing physician.
3. When will I receive my result and how is it delivered?
Your comprehensive genetic report is ready within 3 to 4 weeks from sample receipt. It is delivered via secure encrypted email, and a telephonic consultation with a DHA-licensed genetic counselor is included to review findings and implications.
4. Is home sample collection available for this genetic test?
Yes. VIP Mobile Phlebotomy with temperature-controlled cold-chain transport is available daily from 8 AM to 11 PM. A certified nurse will collect your peripheral blood sample at your home or office, ensuring ISO-compliant specimen integrity throughout the logistics chain.
UAE Regulatory & Data Privacy Adherence
Data Privacy & Legal Compliance
This service operates in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All genetic data is encrypted, access-controlled, and processed exclusively within UAE jurisdiction. Clinical safety and patient consent procedures adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability. Your sample is processed at our ISO 9001:2015 certified facility under DHA Facility License No. 1143.
Clinical & Logistical Metadata
| Test Name | TBC1D24 Gene Autosomal Dominant Deafness Type 65 (DFNA65) Genetic Test |
| Price (AED) | 2,800 AED (All Inclusive) |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Peripheral Whole Blood (VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection Available Daily 8 AM – 11 PM) |
| Methodology Used | Targeted Next-Generation Sequencing (NGS) with Sanger Confirmation |
| ICD-10-CM Code | Z13.71, H90.3, Z82.2 |
| LOINC Code | 82111-3 |
| DHA Facility License & Laboratory Address | DHA Facility License No. 1143 Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE Corporate Lab Branding: DNA Labs UAE |
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All reports reviewed by DHA-Certified physicians