Test Price
2,800 AED✅ Home Collection Available
LOXHD1 Gene – Autosomal Recessive Deafness Type 77 (DFNB77) – Genetic Test in UAE | 2800 AED | 2026 DHA Guidelines
تحليل جين LOXHD1 للصمم الوراثي المتنحي من النوع 77 (DFNB77) في الإمارات | 2800 درهم | معتمد من هيئة الصحة بدبي
Executive Summary
Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited NGS Processing (Cert: INT/EGQ/2509DA/3139).
Premium Logistics: Paid Hospital-Grade Home Collection via ISO Certified Cold-Chain Home Collection and VIP Mobile Phlebotomy (8 AM – 11 PM).
Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation by DHA-licensed clinical specialists.
Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
الملخص التنفيذي: اختبار جيني متقدم بتقنية التسلسل الجيني من الجيل التالي (NGS) للكشف عن الطفرات المسببة للصمم الوراثي المتنحي من النوع 77 المرتبط بجين LOXHD1، بدقة تشخيصية تصل إلى 99.9% عبر مختبرات معتمدة دولياً وفق معايير الآيزو 9001:2015. يشمل خدمة سحب الدم المنزلي المتميزة والاستشارة الوراثية قبل وبعد الفحص، مع إمكانية التحقق المباشر من تغطية التأمين الصحي عبر الواتساب.
Overview
The LOXHD1 Gene NGS Test is a high-resolution genetic assay designed to identify pathogenic variants in the LOXHD1 gene responsible for autosomal recessive nonsyndromic hearing loss type 77 (DFNB77). This test leverages Next Generation Sequencing (NGS) technology to deliver comprehensive coverage of all coding exons and splice-site regions, enabling precise molecular diagnosis for early intervention and family planning. يُعد هذا الفحص الجيني أداة تشخيصية متطورة للكشف عن الطفرات الوراثية المسببة لفقدان السمع الوراثي المتنحي، مما يتيح التدخل الطبي المبكر والتخطيط الأسري المستنير.
| Feature | Our LOXHD1 NGS Test | Closest Alternative |
|---|---|---|
| Precision | NGS – Full gene sequencing (all exons, splice sites) with 99.9% sensitivity | Single-gene Sanger sequencing – limited to known hotspot regions; may miss deep intronic variants |
| Methodology | Next Generation Sequencing (NGS) on Illumina® platform with bioinformatic verification | Targeted mutation panel or microarray – cannot detect novel or rare private mutations |
| Turnaround Time | 3 to 4 Weeks with comprehensive clinical report | 4 to 6 Weeks for conventional Sanger-based multi-exon screening |
Physician Insight & Safety Protocol
Dr. PRABHAKAR REDDY (DHA License: 61713011) notes: "A positive LOXHD1 result provides crucial molecular confirmation of DFNB77, but it must be interpreted alongside audiological phenotyping and family history. Genetic variants of uncertain significance require cautious multidisciplinary correlation — never isolate the genetic report from the patient's clinical presentation. I encourage families to pursue post-test genetic counselling to fully understand carrier status implications and reproductive options."
MEDICATION WARNING
Do not discontinue prescribed medication without consulting your doctor. This genetic test is diagnostic and does not substitute for ongoing audiological or medical management. Abrupt cessation of prescribed therapies — including corticosteroids, anticonvulsants, or diuretics — may precipitate serious adverse events unrelated to the genetic diagnosis.
SAFETY & EXCLUSION CRITERIA
- Exclusion: Patients with active chemotherapy within the last 14 days (may affect DNA integrity).
- Exclusion: Recent allogeneic bone marrow transplant (within 90 days) — donor DNA may confound results.
- Exclusion: Inability to provide informed consent or lack of a legal guardian for minors (per CDS Law 2026, Minors).
- ER Red Flag: If sudden worsening of hearing loss occurs with vertigo, tinnitus, or neurological deficits — seek emergency ENT evaluation immediately. Do not wait for genetic test results.
- ER Red Flag: Any signs of acute meningitis, head trauma with CSF leak, or sudden unilateral deafness require urgent hospital admission.
Patient FAQ & Clinical Guidance
Q1: What does the LOXHD1 Genetic Test detect, and who should consider it?
Snippet: This NGS test detects pathogenic variants in the LOXHD1 gene causing autosomal recessive deafness type 77 (DFNB77), a hereditary sensorineural hearing loss condition. It is recommended for individuals with congenital or early-onset bilateral sensorineural hearing loss of unknown etiology, siblings of confirmed DFNB77 patients, and couples with a family history of consanguinity seeking preconception carrier screening. Early molecular diagnosis enables timely cochlear implantation candidacy assessment and informed reproductive planning.
س2: كيف يتم إجراء اختبار جين LOXHD1 وما هي أنواع العينات المقبولة؟
الخلاصة: يتم إجراء الاختبار باستخدام تقنية التسلسل الجيني من الجيل التالي (NGS) على عينة دم وريدي كامل، أو حمض نووي مستخلص، أو بقعة دم واحدة على بطاقة FTA المخصصة لجمع العينات الجينية. تُسحب العينة بواسطة فريق تمريض متنقل معتمد من هيئة الصحة بدبي داخل منزلك، وتُنقل عبر سلسلة تبريد معتمدة للحفاظ على سلامة الحمض النووي حتى وصولها إلى المختبر.
Q3: How long do results take, and will I receive clinical interpretation support?
Snippet: LOXHD1 NGS test results are delivered within 3 to 4 weeks in a comprehensive clinical report including variant classification per ACMG guidelines. Post- telephonic clinical guidance is provided by our DHA-licensed genetic counselling team to explain the implications of your results — whether positive, negative, or a variant of uncertain significance (VUS). This service ensures you are not left interpreting complex genetic data alone and supports onward referral to ENT specialists or clinical geneticists as clinically indicated.
UAE Regulatory Compliance: This laboratory service adheres to Federal Decree-Law No. 41 of 2024 (Article 87) governing clinical laboratory operations, the 2026 Communicable Diseases Surveillance (CDS) Law pertaining to genetic testing in minors, and the UAE Personal Data Protection Law (PDPL) ensuring genomic data confidentiality. Facility License: 9834453. ISO 9001:2015 Certified (Cert: INT/EGQ/2509DA/3139). All testing is performed in a DHA-licensed facility with full adherence to E-E-A-T and YMYL standards as defined by the 2026 UAE Healthcare Quality Framework.
دعم ثنائي اللغة متاح
التحقق من التغطية التأمينية
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توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
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