Test Price
2,800 AED✅ Home Collection Available
GLRB Gene Hyperekplexia Genetic Test in UAE | 2800 AED | 2026 DHA Guidelines
تحليل تسلسل جين GLRB لفرط الرمع الجيني (Hyperekplexia) بتقنية NGS في الإمارات | 2800 درهم | إرشادات هيئة الصحة بدبي 2026
Executive Summary & Arabic Local Trust
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing.
- Premium Logistics: Paid Hospital-Grade Home Collection via ISO Certified Cold-Chain Home Collection and VIP Mobile Phlebotomy.
- Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation by a certified genetic counselor.
- Insurance: Direct Billing Verification via WhatsApp at +971 54 548 8731.
الملخص التنفيذي: يضمن هذا الاختبار دقة تشخيصية بنسبة 99.9% من خلال معالجة معملية معتمدة بموجب ISO 9001:2015. تشمل الخدمة جمع العينات في المنزل بواسطة فريق تمريض مرخص ونقل بسلسلة تبريد معتمدة، إلى جانب استشارة هاتفية بعد النتائج لتفسير التقرير الجيني. يتم التحقق من تغطية التأمين الصحي عبر واتساب على الرقم 971-54-548-8731.
Test Overview & Clinical Context
The GLRB gene hyperekplexia NGS test analyzes the entire coding sequence of the glycine receptor beta subunit gene to identify pathogenic variants associated with hereditary hyperekplexia (startle disease). This condition, characterized by neonatal stiffness, exaggerated startle responses, and apnea, requires early diagnosis for appropriate management.
يستخدم هذا الاختبار تقنية التسلسل الجيني عالي الإنتاجية لتوفير تحليل شامل لجين GLRB، مما يساعد في تأكيد التشخيص لدى المرضى الذين يعانون من أعراض فرط الرمع الجيني.
| Feature | Our GLRB NGS Test | Sanger Sequencing (Alternative) |
|---|---|---|
| Methodology | Next-Generation Sequencing (NGS) – full gene coverage | Single‑variant or specific exon analysis |
| Diagnostic Sensitivity | 99.9% for coding variants | ~99% for targeted region |
| Turnaround Time | 3 – 4 Weeks | 4 – 6 Weeks |
| Sample Type | Blood, Extracted DNA, or One drop Blood on FTA Card | Blood only |
| Price | 2800 AED | Variable, often higher |
Clinical Coding (2026 ICD‑10‑CM & LOINC)
Primary Diagnosis: G25.89 (Other specified extrapyramidal and movement disorders – Hyperekplexia)
Susceptibility/Genetic Marker: Z14.8 (Genetic susceptibility to other disease), E72.8 (Other specified disorders of amino-acid metabolism)
Laboratory Code: LOINC 94480‑2 – GLRB gene mutations found [Identifier] in Blood or Tissue by Molecular genetics method (loinc.org/94480-2)
Physician Insight & Safety Protocol
“As a neurologist, I understand the anxiety a hyperekplexia diagnosis can bring. This test provides clarity, but its result must be integrated with a full neurological assessment. A positive finding guides therapy and genetic counseling, while a negative result may still necessitate further investigation. Please discuss all results with your physician.”
— Dr. PRABHAKAR REDDY, DHA License: 61713011
Medication Warning: Do not discontinue or modify any prescribed medication without consulting your primary neurologist.
Safety Exclusion Criteria & Emergency Red Flags
- Exclusion: Patients in acute neurological crisis (status epilepticus, uncontrolled seizures) cannot undergo home collection; emergency hospital referral is mandatory.
- Exclusion: Sedated or unresponsive individuals, and minors without legal guardian consent, are not eligible for this elective genetic test.
- Red Flag: Sudden onset of extreme muscle stiffness with breathing difficulty or loss of consciousness after a startle – seek immediate emergency care.
- Red Flag: Infants displaying apnea or prolonged cyanosis after startle require urgent neonatal ICU evaluation.
Patient FAQ & Clinical Guidance
What is the GLRB gene hyperekplexia test and why is it performed?
The GLRB NGS test sequences the glycine receptor beta subunit gene to diagnose hereditary hyperekplexia, a rare startle disorder causing stiffness and apnea. يقوم هذا الاختبار بتسلسل جين GLRB لتشخيص فرط الرمع الجيني الوراثي، وهو اضطراب نادر يبدأ بالارتجاف والتصلب ونوبات انقطاع النفس.
How is the sample collected and what is the turnaround time?
A simple blood draw or buccal swab is collected at home by a DHA-licensed phlebotomist, with results delivered within 3-4 weeks. يتم جمع العينة في المنزل عبر سحب دم بسيط أو مسحة فموية بواسطة أخصائي معتمد من هيئة الصحة بدبي، وتصدر النتائج خلال 3 إلى 4 أسابيع.
Is genetic counseling required before or after the test?
Yes, pre-test counseling with a certified genetic counselor is mandatory to interpret family history and post- results for informed decisions. نعم، الاستشارة الوراثية قبل الاختبار مع مستشار وراثي معتمد إلزامية لتفسير التاريخ العائلي ولتوجيه القرارات بعد ظهور النتائج.
UAE Regulatory Compliance & Data Privacy
This service strictly adheres to Federal Decree-Law No. 41 of 2024 (Article 87) on health data protection, CDS Law 2026 regarding minors’ genetic testing, and UAE PDPL. Our laboratory holds ISO 9001:2015 Certification (Cert: INT/EGQ/2509DA/3139) and operates under DHA/MOHAP facility license 9834453. All home collection staff are DHA-certified and follow rigorous cold‑chain protocols.
دعم ثنائي اللغة متاح
التحقق من التغطية التأمينية
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Stop the guesswork. Send a photo of your Insurance Card and Doctor's Prescription to our DHA-Certified Verification Team on WhatsApp.
توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
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