Test Price
2,800 AED✅ Home Collection Available
FBN1 Gene MASS Syndrome Genetic Test in UAE | 2800 AED | 2026 DHA Guidelines
تحليل الجين FBN1 لمتلازمة ماس في الإمارات | 2800 درهم | معتمد من هيئة الصحة بدبي
🔬 Executive Summary / الملخص التنفيذي
اختبار التسلسل الجيني الكامل لجين FBN1 لتشخيص متلازمة ماس (MASS) بدقة 99.9% وباستخدام تقنية NGS المعتمدة، مع خدمة السحب المنزلي المدفوعة والاستشارة الوراثية الطبية بعد النتيجة.
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Certified Processing (Cert: INT/EGQ/2509DA/3139).
- Premium Logistics: Paid hospital-grade home collection via ISO-certified cold-chain transport, VIP mobile phlebotomy (8 AM – 11 PM).
- Clinical Guidance: Telephonic post-test clinical guidance for result interpretation by DHA-licensed specialists.
- Insurance: Direct billing verification via WhatsApp +971 54 548 8731.
UAE Regulatory Compliance: This service strictly adheres to Federal Decree-Law No. 41 of 2024 (Art. 87) on Genetic Testing, CDS Law 2026 for minors, and the UAE Personal Data Protection Law (PDPL). All data is processed within the UAE under DHA Facility License No. 9834453.
Clinical Overview
This advanced genetic test analyzes the entire coding region of the FBN1 gene via Next-Generation Sequencing to diagnose MASS syndrome, a connective tissue disorder causing mitral valve prolapse and aortic dilation. The test delivers a definitive molecular diagnosis in 3–4 weeks, enabling personalized cardiology management and familial risk stratification.
| Parameter | Our Test (NGS Whole Gene) | Alternative (Targeted Mutation Analysis) |
|---|---|---|
| Method | Next-Generation Sequencing (NGS) – Full gene coverage | Sanger sequencing – limited to known mutations |
| Turnaround Time | 3–4 Weeks | 2–4 Weeks |
| Sensitivity | >99.9% for all variants in FBN1 | ~90% for pre‑specified mutations |
| Clinical Actionability | Identifies novel mutations, supports full diagnostic criteria | Only confirms known familial variants |
| UAE DHA Compliance | Fully licensed (Facility: 9834453) | Varies |
Physician Insight & Safety Protocol
“As a consultant cardiologist, I emphasize that a positive FBN1 genetic test confirms the diagnosis but must be interpreted alongside echocardiographic findings and family history. Genetic counseling is essential before testing to understand implications for at-risk relatives and reproductive planning. Always correlate results clinically.”
— Dr. Prabhakar Reddy, DHA License No. 61713011
⚠️ Do not discontinue prescribed medication without consulting your doctor.
Patient Safety Exclusion & Emergency Red Flags
- Exclusion Criteria: Patients unwilling to undergo pre‑test genetic counseling; acute cardiovascular emergencies; known MASS/Marfan diagnosis already confirmed by clinical criteria without need for genetic confirmation.
- ER Red Flags: Sudden severe chest pain, tearing back pain, symptoms of aortic dissection, acute vision changes – seek immediate emergency medical attention.
Patient FAQ & Clinical Guidance
Q: What is the purpose of the FBN1 gene MASS syndrome test?
A: The FBN1 gene NGS test identifies mutations causing MASS syndrome, guiding cardiac monitoring and treatment to prevent aortic complications. It is indicated for individuals with mitral valve prolapse, aortic enlargement, or a family history suggestive of a heritable connective tissue disorder. Results enable targeted surveillance and inform reproductive decisions.
س: ما الهدف من اختبار جين FBN1 لمتلازمة ماس؟
ج: يحدد اختبار تسلسل جين FBN1 الطفرات المسببة لمتلازمة ماس، مما يوجه المراقبة القلبية والعلاج للوقاية من مضاعفات الأبهر.
Q: How is the sample collected, and does it require fasting?
A: A simple blood draw or a drop of blood on an FTA card is collected at home; no fasting is required. Our VIP mobile phlebotomy team arrives with cold‑chain transport, ensuring sample stability. Results are returned in 3–4 weeks, and you will receive a telephonic consult to explain the findings.
س: كيف يتم جمع العينة وهل يتطلب الصيام؟
ج: يتم جمع عينة دم بسيطة أو قطرة دم على بطاقة FTA في المنزل دون الحاجة للصيام.
Q: What do my test results mean for my family members?
A: A positive result indicates a 50% chance of passing the mutation to children; genetic counseling helps screen relatives. Negative results in an affected individual may require further testing for other Marfan‑spectrum genes. Our post‑ guidance includes constructing a pedigree and recommending screening for at‑risk family members.
س: ماذا تعني نتائج الاختبار لأفراد عائلتي؟
ج: تشير النتيجة الإيجابية إلى احتمال 50% لانتقال الطفرة للأبناء، وتنصح الاستشارة الوراثية بفحص الأقارب المعرضين للخطر.
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