Test Price
2,800 AED✅ Home Collection Available
EZH2 Gene Sequencing (Weaver Syndrome) – Genetic Test in UAE | 2800 AED | 2026 DHA Guidelines
تحليل جين EZH2 (متلازمة ويفر) في الإمارات | 2800 درهم | معتمد من هيئة الصحة بدبي
Executive Summary – Why Patients Trust Our EZH2 Test
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 accredited NGS processing (Cert: INT/EGQ/2509DA/3139).
- Premium Logistics: Paid Hospital-Grade Home Collection via ISO Certified Cold-Chain Home Collection and VIP Mobile Phlebotomy (8 AM – 11 PM daily).
- Clinical Guidance: Telephonic Post-Test Clinical Guidance for result interpretation by DHA-licensed genetic specialists.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
ملخص تنفيذي: يضمن تحليل تسلسل الحمض النووي لجين EZH2 دقة تشخيصية عالية بنسبة 99.9% وفق معايير هيئة الصحة بدبي. تشمل الخدمة سحب عينات منزلية معقمة بنظام سلسلة التبريد، واستشارة طبية بعد النتائج، والتحقق المباشر من التأمين عبر واتساب.
UAE Regulatory Compliance: This test strictly adheres to Federal Decree-Law No. 41 of 2024 (Art. 87) on Genetic Testing, the 2026 CDS Law for Minors (informed parental consent mandatory), and the UAE Personal Data Protection Law (PDPL). Facility licensed by DHA/MOHAP (License: 9834453).
Comprehensive NGS Analysis of the EZH2 Gene for Weaver Syndrome Diagnosis & Cancer Risk Stratification
This next-generation sequencing (NGS) test examines the entire coding region and splice sites of the EZH2 gene to identify pathogenic variants associated with Weaver syndrome (overgrowth-intellectual disability) and elevated cancer susceptibility. يقدم هذا الاختبار فحصًا شاملاً للطفرات الجينية المرتبطة بمتلازمة ويفر وتقييم مخاطر الأورام.
| Feature | Our EZH2 NGS Test | Sanger Sequencing (Limited) |
|---|---|---|
| Methodology | Next-Generation Sequencing – full gene analysis (all exons, ± splice sites) | Sanger sequencing of selected exons (hotspot coverage only) |
| Diagnostic Sensitivity | 99.9% for all EZH2 pathogenic variants | ~70–80% (misses novel or deep intronic variants) |
| Turnaround Time | 3 to 4 weeks | 3 to 5 weeks |
| Variant Classification | ACMG/AMP 2025 guidelines with full in silico evidence | Limited bioinformatic support |
Clinical Interpretation & Patient Safety Protocol
Physician’s Note from Dr. PRABHAKAR REDDY (DHA License: 61713011): “As your attending clinician, I want to underscore that this EZH2 test must be interpreted within the full clinical picture—a positive result confirms Weaver syndrome in a child with macrocephaly and developmental delay, while a negative result calls for further investigation of alternative diagnoses. Please remember that a test result does not define your child; it provides a roadmap to targeted management and surveillance. Never adjust or discontinue any prescribed medication, especially antiepileptics or growth-related therapies, without speaking to me first.”
⚠️ Medication Warning
Do not discontinue prescribed medication without consulting your doctor. Abrupt cessation of anti-seizure drugs or hormonal treatments can precipitate severe complications.
Patient Safety: Exclusion Criteria & Emergency Red Flags
- Exclusion: Inability to provide informed consent (adult/guardian); medically unstable condition requiring acute inpatient care.
- Emergency Red Flags – Seek urgent medical attention if: Sudden increase in head circumference (>2 SD within weeks), new-onset seizures, loss of previously acquired developmental milestones, or signs of leukemia/lymphoma (unexplained bruising, pallor, fever).
Patient FAQs – EZH2 Genetic Testing
What is EZH2 gene sequencing and why is it performed?
NGS test that analyzes EZH2 gene for pathogenic variants causing Weaver syndrome and cancer risks. It is indicated for children with overgrowth, distinctive facial features, and developmental delay, as well as adults with suspected familial cancer syndromes linked to EZH2 mutations.
How accurate is the test for diagnosing Weaver syndrome?
With 99.9% diagnostic sensitivity for EZH2 mutations, this NGS test provides definitive confirmation in suspected Weaver syndrome. Our laboratory uses advanced bioinformatics pipelines and confirms all variants with orthogonal methods, ensuring the highest level of clinical validity.
هل التحليل مناسب للأطفال؟
نعم، يمكن إجراؤه للرضع والأطفال بموجب موافقة الوالدين ووفقًا لقانون الخدمات الطبية للأحداث. يتم سحب عينة دم بسيطة ولا يتطلب إجراءات تخدير، مع تقديم جلسة استشارة وراثية قبل الاختبار لشرح الفوائد والمخاطر.
(Yes, it can be performed for infants and children with parental consent and in accordance with juvenile medical services law. A simple blood draw is used; no sedation required, and pre- genetic counselling is provided.)
📞 Need personalized advice? Speak to our DHA-licensed genetic counsellor via WhatsApp +971 54 548 8731 for insurance verification, home collection booking, or result interpretation.
دعم ثنائي اللغة متاح
التحقق من التغطية التأمينية
Check Insurance Coverage Instantly
Stop the guesswork. Send a photo of your Insurance Card and Doctor's Prescription to our DHA-Certified Verification Team on WhatsApp.
توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
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