Test Price
2,800 AED✅ Home Collection Available
H19 Gene Beckwith-Wiedemann Syndrome Genetic Test in UAE | 2800 AED | DHA Licensed
Executive Summary & Core Metrics
- ✓ Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO Accredited Processing.
- ✓ Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection — available daily from 8 AM to 11 PM.
- ✓ Clinical Guidance: Post-test telephonic genetic counseling with a Consultant Medical Genetics.
- ✓ Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The H19 Gene Beckwith-Wiedemann Syndrome NGS Test detects pathogenic variants and methylation abnormalities in the H19 gene, aiding diagnosis of Beckwith-Wiedemann syndrome (BWS) and associated cancer predisposition. This comprehensive molecular analysis uses next-generation sequencing to achieve single-nucleotide resolution across the entire gene, providing higher diagnostic yield than conventional methods.
| Feature | Our Test | Closest Alternative (Standard MLPA/Methylation) |
|---|---|---|
| Precision | Comprehensive NGS of entire H19 gene, single‑nucleotide resolution | Limited to known deletion/duplication and methylation pattern |
| Method | Next‑Generation Sequencing (NGS) | Multiplex Ligation‑dependent Probe Amplification (MLPA) / Methylation‑specific PCR |
| Speed | 3–4 Weeks | 4–6 Weeks |
Physician Insight & Safety Protocols
"As a consultant medical geneticist, I understand the anxiety families face when investigating genetic syndromes like Beckwith-Wiedemann. This test provides critical molecular information that, when integrated with clinical evaluation, can guide surveillance and management. Our role is to deliver both precision and compassionate support throughout the journey."
— Lina Osama Zaki Quteineh, Consultant Medical Genetics (DHA: 9294403)
Genetic Counseling Advisory
Pre- and post-test genetic counseling is strongly recommended to interpret results in the context of family history, clinical features, and surveillance protocols. Our consultant geneticist is available for telephonic guidance following result release.
Safety Exclusion Criteria & Emergency Red Flags
- Exclusion: Recent blood transfusion or history of allogeneic bone marrow transplant (may interfere with DNA analysis).
- Exclusion: Non‑consenting minors – genetic testing requires informed consent from legal guardian per Federal Decree-Law No. 4 of 2016 on Medical Liability and the UAE Personal Data Protection Law.
- Red Flag: Rapidly progressive asymmetry of limbs or facial features, or sudden organomegaly (possible embryonal tumor). Seek immediate pediatric oncology evaluation.
- Red Flag: Unexplained abdominal mass or hematuria in a child (suspected Wilms tumor). Immediate imaging and referral required.
Patient FAQ & Clinical Guidance
1. What is the H19 Gene Beckwith‑Wiedemann Syndrome NGS Test?
This test analyzes the H19 gene for mutations and methylation changes to confirm a diagnosis of Beckwith-Wiedemann syndrome and assess the risk of associated childhood cancers such as Wilms tumor and hepatoblastoma.
2. Why is this test recommended?
It is recommended for children presenting with overgrowth features (e.g., macrosomia, macroglossia, hemihyperplasia), abdominal wall defects (omphalocele), or a family history of Beckwith‑Wiedemann syndrome to guide clinical management and tumor surveillance.
3. How is the sample collected and what is the turnaround time?
Sample collection uses a standard peripheral blood draw or FTA card spot. Results are available within 3 to 4 weeks. VIP mobile phlebotomy and home collection are available across the UAE from 8 AM to 11 PM daily.
4. Does insurance cover this test?
We offer direct billing assistance. Please contact our team via WhatsApp at +971 54 548 8731 to verify your insurance coverage prior to testing.
UAE Regulatory & Data Privacy Adherence
This test is performed in full compliance with:
- Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL)
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields
- Federal Decree-Law No. 4 of 2016 on Medical Liability (patient consent and safety)
Our laboratory is ISO 9001:2015 certified (Cert: INT/EGQ/2509DA/3139) and operates under DHA Facility License No. 1143.
Clinical & Logistical Metadata
| Test Name | H19 Gene Beckwith-Wiedemann Syndrome NGS Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Peripheral whole blood (3–5 mL in EDTA tube) or FTA card spot |
| Methodology Used | Next-Generation Sequencing (NGS) with methylation analysis |
| ICD-10-CM Code | Q87.3 |
| LOINC Code | 48000-9 |
| DHA Facility License & Laboratory Address | DNA Labs UAE, DHA License No. 1143, Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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