Test Price
800 AED✅ Home Collection Available
MTHFR Gene Mutation Analysis (C677T & A1298C) – Precision PCR in Dubai, UAE
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Real‑Time PCR Processing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature‑Controlled Cold‑Chain Home Collection (Daily 8 AM to 11 PM).
- Clinical Guidance: Telephonic Post‑Test Result Interpretation by DHA‑Licensed Genetics Specialist.
- Insurance & Booking: Direct Billing Verification & Appointment via WhatsApp +971 54 548 8731.
Test Overview & Methodology
MTHFR gene analysis detects the two clinically significant variants C677T and A1298C, which govern folate metabolism and homocysteine regulation – essential for cardiovascular, neurological, and pregnancy health. Our targeted real‑time PCR approach delivers rapid, high‑specificity results compared to broader genomic alternatives.
| Feature | Our MTHFR Test (Real‑Time PCR) | Closest Alternative (Whole Genome Sequencing – WGS) |
|---|---|---|
| Method | TaqMan® Allelic Discrimination qPCR (High Specificity) | Short‑Read WGS + Bioinformatic Filtering |
| Diagnostic Precision | 99.9% Sensitivity & 100% Specificity for targeted variants | Variable; risk of incidental findings and analytic noise |
| Turnaround Time | 3–4 Days | 2–4 Weeks |
| UAE Regulatory Compliance | DHA‑Licensed (Facility 1143) + ISO 9001:2015 | Varies by provider; often lacks local accreditation |
| Clinical Focus | Actionable folate/homocysteine risk stratification | Broad genome screen; clinical relevance may be unclear |
Physician Insight & Safety Protocols
Clinical Correlation Note – Lina Osama Zaki Quteineh (DHA License: 9294403):
“As your supervising genetics consultant, I emphasize that MTHFR genotype results must be integrated with your full clinical picture, including homocysteine levels, folate status, and personal risk factors. A heterozygous or homozygous result alone is not a diagnosis; it guides targeted prevention when combined with a physician’s assessment. Never self‑interpret or adjust medications based solely on genetic findings.”
⚠️ Important Safety & Exclusion Criteria
Do not discontinue prescribed medication without consulting your doctor. Genetic test results do not replace individualised therapeutic decisions.
- Exclusion Criteria: Not for acute emergency assessment; requires legal guardian consent for minors per Federal Decree-Law No. 4 of 2016 on Medical Liability. Contraindicated in patients unable to provide a peripheral blood sample.
- Pre‑Test Requirement: A valid doctor’s prescription is mandatory. Exception may apply for pregnancy‑related testing (e.g., recurrent loss risk) or official documentation with DHA/MOHAP approval.
- 🚨 Red Flags: Seek emergency care immediately if you experience sudden severe headache, chest pain, shortness of breath, or focal neurological signs. MTHFR testing is a risk assessment tool, not an acute diagnostic.
Patient FAQ & Clinical Guidance
1. What is the clinical significance of MTHFR C677T and A1298C variants?
MTHFR variants impair folate metabolism, raising homocysteine levels and risks for heart disease, clots, and pregnancy complications. These genetic changes can reduce your ability to use folic acid, leading to elevated homocysteine – a marker associated with cardiovascular events, venous thromboembolism, and neural tube defects. Genetic counselling is recommended after testing.
2. Do I need to stop medications or supplements before the MTHFR test?
No medication or supplement stoppage is needed; the DNA‑based test is unaffected by drugs or vitamins. Because the analysis examines your inherited genetic code, not transient metabolite levels, you can continue your usual prescriptions and nutritional supplements. Always confirm with the ordering physician.
3. How fast are my results delivered, and can I get help understanding them?
Results are available in 3‑4 days, including a telehealth consult to explain your MTHFR genotype impact. All reports include your genotype (wild‑type, heterozygous, homozygous) for each variant and a clinical interpretation. Our DHA‑licensed team provides a complimentary telephonic guidance session, and you can share the report with your nutritionist or functional medicine practitioner.
UAE Regulatory & Data Privacy Adherence
✅ Regulatory Compliance & Data Protection
This test adheres to Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Patient consent procedures follow Federal Decree-Law No. 4 of 2016 on Medical Liability. Our laboratory holds ISO 9001:2015 certification (INT/EGQ/2509DA/3139) and DHA Facility License 1143.
Clinical & Logistical Metadata
| Test Name | MTHFR C677T & A1298C Mutation Analysis |
| Price (AED) | 800 AED |
| Turnaround Time | 3–4 Business Days |
| Sample Type / Matrix | Peripheral Whole Blood (3-5 mL in EDTA Lavender-Top Tube) |
| Methodology Used | TaqMan® Allelic Discrimination Real-Time PCR (qPCR) |
| ICD-10-CM Code | Z13.89 – Encounter for screening for other specified diseases and disorders |
| LOINC Code | 48768-8 – MTHFR gene mutation analysis |
| DHA Facility License & Address | DHA License 1143 – Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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All reports reviewed by DHA-Certified physicians