Test Price
2,800 AED✅ Home Collection Available
NOTCH3 Gene (CADASIL) Genetic Test in UAE | 2800 AED | 2026 DHA Guidelines
تحليل جين NOTCH3 للكشف عن مرض CADASIL في الإمارات | 2800 درهم | معتمد من هيئة الصحة بدبي
Clinical Excellence Guarantee: This NGS-based test achieves 99.9% diagnostic sensitivity for pathogenic NOTCH3 variants, processed under ISO 9001:2015‑certified protocols (Cert: INT/EGQ/2509DA/3139).
Premium Home Collection: Complimentary hospital‑grade, ISO‑certified cold‑chain phlebotomy service (8 AM – 11 PM) across all UAE emirates – your sample remains stable from vein to sequencer.
Post‑Test Clinical Guidance: Receive a telephonic interpretation session with a DHA‑licensed genetic counsellor, ensuring you understand your results and their implications.
Insurance & Billing: Direct insurance verification via WhatsApp at +971 54 548 8731 before your draw, with most major UAE networks accepted.
الملخص التنفيذي: يقدم اختبار تسلسل الجيل التالي (NGS) لجين NOTCH3 تشخيصًا دقيقًا لمرض CADASIL الوراثي. يتم التحليل في مختبر معتمد من هيئة الصحة بدبي وفقًا لمعايير ISO 9001:2015، مع خدمة سحب منزلي احترافية ودعم تفسير سريري بعد النتيجة. سعر الاختبار 2800 درهم إماراتي، ومدة ظهور النتيجة من 3 إلى 4 أسابيع. يلتزم المختبر بقانون الصحة الاتحادي رقم 41 لسنة 2024 وقانون حماية البيانات الشخصية.
Overview
The NOTCH3 Gene CADASIL Genetic Test screens the entire coding region of the NOTCH3 gene using Next‑Generation Sequencing, detecting single‑nucleotide variants, indels, and copy‑number changes linked to Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL). This test is designed for symptomatic individuals with migraine with aura, recurrent stroke, cognitive decline, or a family history of the condition, and delivers a definitive molecular diagnosis.
يُستخدم اختبار NOTCH3 NGS للكشف عن الطفرات المسببة لمرض CADASIL الوعائي الوراثي. يتميز بدقة عالية ويغطي كامل المنطقة المشفرة للجين.
| Feature | Our Test (NGS) | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Methodology | Whole‑gene NGS with CNV detection | Targeted single‑exon Sanger |
| Sensitivity | >99.9% for known CADASIL mutations | ~95% (limited by exon selection) |
| Turnaround Time | 3–4 Weeks | 4–6 Weeks |
| UAE Regulatory Compliance | Full – ISO 9001:2015 & DHA‑licensed | Variable |
Physician Insight & Safety Protocol
“This test should always be interpreted within the full clinical picture. A negative result does not exclude rare non‑coding variants or other stroke‑mimic disorders. I strongly encourage a genetic counselling session before sample collection to map the family pedigree and discuss the implications of a positive finding. As a DHA‑licensed physician (DHA: 61713011), I will personally oversee the clinical correlation of your result.”
— Dr. Prabhakar Reddy, Consultant in Molecular & Genetic Medicine
⚠️ Medication Safety Notice
Do not discontinue or adjust any prescribed medication (e.g., antiplatelets, antihypertensives, migraine preventives) without consulting your treating physician. CADASIL requires careful management; sudden changes can precipitate stroke or severe migraine attacks.
Patient Exclusion Criteria
- Individuals with active uncontrolled bleeding or coagulopathy contraindicating venipuncture.
- Patients who have received an allogeneic bone marrow transplant – the sample may contain donor DNA.
- Current use of heparin at therapeutic doses (risk of sample haemolysis).
- Minors without legally authorised guardian consent (UAE CDS Law 2026 compliance).
Emergency Red Flags – Seek immediate medical attention if you experience:
- Sudden severe headache with neurological deficits (suspected stroke).
- Acute vision loss or speech difficulty.
- Loss of consciousness or status epilepticus.
Frequently Asked Questions
What sample types are accepted for the NOTCH3 CADASIL in the UAE?
We accept whole blood collected in EDTA tubes, extracted DNA, or a single drop of blood dried on an FTA card – all processed under ISO‑certified cold‑chain logistics to guarantee integrity during the 3‑ to 4‑week NGS turnaround.
هل يمكن إجراء الاختبار في المنزل في الإمارات؟
نعم، نوفر خدمة سحب الدم المنزلي من الساعة 8 صباحًا حتى 11 مساءً في جميع أنحاء الإمارات، ويتم نقل العينة في حافظة مبردة وفق معايير ISO، مع ضمان استقرار الحمض النووي حتى بدء التحليل.
Will my genetic data be stored securely under UAE law?
Yes, your data is protected by the UAE Personal Data Protection Law (PDPL) and Federal Decree‑Law No. 41 of 2024; all genetic information is encrypted, stored on local servers, and never shared without explicit consent.
📞 Book your VIP home collection or verify insurance coverage instantly: +971 54 548 8731 (WhatsApp & Phone)
DHA Facility License: 9834453 | ISO 9001:2015 (Cert: INT/EGQ/2509DA/3139)
دعم ثنائي اللغة متاح
التحقق من التغطية التأمينية
Check Insurance Coverage Instantly
Stop the guesswork. Send a photo of your Insurance Card and Doctor's Prescription to our DHA-Certified Verification Team on WhatsApp.
توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
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ISMS 27001:2022
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All reports reviewed by DHA-Certified physicians