Test Price
2,800 AED✅ Home Collection Available
NOTCH3 Gene (CADASIL) Genetic Test – Dubai, UAE
Executive Summary & Core Metrics
Clinical Excellence Guarantee: This NGS‑based test achieves 99.9% diagnostic sensitivity for pathogenic NOTCH3 variants, processed under ISO 9001:2015‑certified protocols (Cert: INT/EGQ/2509DA/3139) at DNA Labs UAE.
Premium Home Collection: Complimentary hospital‑grade, ISO‑certified cold‑chain phlebotomy service (8 AM – 11 PM) across all UAE emirates – your sample remains stable from vein to sequencer.
Post‑Test Clinical Guidance: Receive a telephonic interpretation session with a DHA‑licensed genetic counsellor (Lina Osama Zaki Quteineh, Consultant Medical Genetics), ensuring you understand your results and their implications.
Insurance & Billing: Direct insurance verification via WhatsApp at +971 54 548 8731 before your draw, with most major UAE networks accepted. Test price: 2,800 AED.
Test Overview & Methodology
The NOTCH3 Gene CADASIL Genetic Test screens the entire coding region of the NOTCH3 gene using Next‑Generation Sequencing, detecting single‑nucleotide variants, indels, and copy‑number changes linked to Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL). This test is designed for symptomatic individuals with migraine with aura, recurrent stroke, cognitive decline, or a family history of the condition, and delivers a definitive molecular diagnosis.
| Feature | Our Test (NGS) | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Methodology | Whole‑gene NGS with CNV detection | Targeted single‑exon Sanger |
| Sensitivity | >99.9% for known CADASIL mutations | ~95% (limited by exon selection) |
| Turnaround Time | 3–4 Weeks | 4–6 Weeks |
| UAE Regulatory Compliance | Full – ISO 9001:2015 & DHA‑licensed (1143) | Variable |
Physician Insight & Safety Protocols
“This test should always be interpreted within the full clinical picture. A negative result does not exclude rare non‑coding variants or other stroke‑mimic disorders. I strongly encourage a genetic counselling session before sample collection to map the family pedigree and discuss the implications of a positive finding. As a DHA‑licensed Consultant Medical Genetics (DHA: 9294403), I will personally oversee the clinical correlation of your result.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics
Advisory – Medication Safety
⚠️ Medication Safety Notice
Do not discontinue or adjust any prescribed medication (e.g., antiplatelets, antihypertensives, migraine preventives) without consulting your treating physician. CADASIL requires careful management; sudden changes can precipitate stroke or severe migraine attacks.
Exclusion Criteria & Emergency Red Flags
Patient Exclusion Criteria
- Individuals with active uncontrolled bleeding or coagulopathy contraindicating venipuncture.
- Patients who have received an allogeneic bone marrow transplant – the sample may contain donor DNA.
- Current use of heparin at therapeutic doses (risk of sample haemolysis).
- Minors without legally authorised guardian consent (per UAE medical liability law).
Emergency Red Flags – Seek immediate medical attention if you experience:
- Sudden severe headache with neurological deficits (suspected stroke).
- Acute vision loss or speech difficulty.
- Loss of consciousness or status epilepticus.
Patient FAQ & Clinical Guidance
1. What sample types are accepted for the NOTCH3 CADASIL genetic test in the UAE?
We accept whole blood collected in EDTA tubes, extracted DNA, or a single drop of blood dried on an FTA card – all processed under ISO‑certified cold‑chain logistics to guarantee integrity during the 3‑ to 4‑week NGS turnaround.
2. Can home phlebotomy be arranged for this genetic test?
Yes, we provide VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM across all UAE emirates. Your sample remains stable from vein to sequencer.
3. How is my genetic data protected under UAE law?
Your data is protected by the Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All genetic information is encrypted, stored on local servers, and never shared without explicit consent.
4. What does the test price include?
The price of 2,800 AED includes the NGS sequencing analysis, bioinformatics interpretation, a detailed clinical report, and a telephonic post-test counselling session with a DHA-licensed genetic counsellor. It does not include any additional physician consultation fees.
UAE Regulatory & Data Privacy Adherence
Data Privacy & Legal Compliance
- Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL): All genetic data is processed, stored, and transferred in full compliance with this law.
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields: Digital health records and telecounselling sessions follow strict ICT security standards.
- Federal Decree-Law No. 4 of 2016 on Medical Liability: Clinical decisions and patient safety protocols adhere to this governing framework.
DNA Labs UAE is a DHA-licensed facility (License No. 1143) operating under the regulatory oversight of the Dubai Health Authority. All testing is performed in our CAP-accredited laboratory located in Dubai Healthcare City.
Clinical & Logistical Metadata
| Test Name | NOTCH3 Gene (CADASIL) Genetic Test |
| Price (AED) | 2,800 |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Whole Blood (EDTA), Extracted DNA, or Dried Blood Spot (FTA Card) |
| Methodology Used | Next-Generation Sequencing (NGS) with CNV Detection |
| ICD-10-CM Code | I67.850 |
| LOINC Code | 59089-2 |
| DHA Facility License & Laboratory Address | DHA License: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | Corporate Lab: DNA Labs UAE |
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