Test Price
2,800 AED✅ Home Collection Available
LRP2 Gene Donnai-Barrow Syndrome Genetic Test in UAE | 2800 AED | DHA Approved
Executive Summary & Core Metrics
Executive Summary
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM).
- Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The LRP2 Gene Donnai-Barrow Syndrome Genetic Test provides a comprehensive analysis of the LRP2 gene using next-generation sequencing (NGS) to identify pathogenic variants responsible for Donnai-Barrow syndrome, also known as facio-oculo-acoustico-renal (FOAR) syndrome. This test delivers high-depth coverage across the entire LRP2 coding region, enabling detection of single nucleotide variants, insertions, and deletions with exceptional sensitivity.
| Feature | Our Test (NGS) | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Methodology | NGS – Full Coding Region Analysis | Single-gene Sanger Sequencing |
| Precision | High-depth coverage, entire LRP2 coding region | Exon-by-exon, lower throughput |
| Turnaround Time | 3 to 4 Weeks | 4 to 6 Weeks |
| Sensitivity | 99.9% for SNVs and indels | ~99% |
Physician Insight & Safety Protocols
"Understanding the genetic basis of Donnai-Barrow syndrome is essential for guiding clinical management and family planning. This comprehensive NGS analysis of the LRP2 gene offers high diagnostic yield, yet results must be interpreted alongside the full clinical picture and pedigree data. I strongly recommend pre- and post-test genetic counseling to ensure families fully grasp the implications of any findings."
— Lina Osama Zaki Quteineh | Consultant Medical Genetics | DHA Registration ID: 9294403
Advisory & Medication Safety
⚠️ Important Medication Advisory
Do not discontinue or modify any prescribed medications without consulting your treating physician. This genetic test is a diagnostic adjunct and does not replace ongoing clinical management or therapeutic oversight.
Patient Safety Exclusion Criteria
Red Flags & Exclusion Criteria
- Exclusion Criteria: Individuals unable to provide informed consent or a viable genomic sample (whole blood, FTA card, or extracted DNA). This test is not intended for acute diagnostic emergencies.
- Red Flags – Seek Emergency Care Immediately: Acute renal failure indicators (e.g., markedly decreased urine output, severe edema), life-threatening electrolyte disturbances, sudden sensorineural hearing loss, or rapid deterioration of vision.
- Mandatory Pre-test Requirement: A formal genetic counseling session to construct a three-generation pedigree chart documenting all family members affected by or carriers of Donnai-Barrow syndrome is required before sample collection.
Patient FAQ & Clinical Guidance
1. What is the LRP2 Gene Donnai-Barrow Syndrome Genetic Test?
This NGS-based test analyzes the entire LRP2 gene to identify pathogenic mutations that cause Donnai-Barrow syndrome (facio-oculo-acoustico-renal syndrome). It is a comprehensive molecular diagnostic tool designed for individuals with clinical features suggestive of this rare autosomal recessive disorder.
2. How much does the test cost and what is the turnaround time?
The test is priced at 2,800 AED with a turnaround time of 3 to 4 weeks from sample receipt. The fee includes pre-test genetic counseling for pedigree construction and post-test telephonic guidance.
3. What sample is required and how is home collection arranged?
We accept whole blood, FTA card blood spot, or extracted DNA. Our DHA-licensed phlebotomists provide VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection daily from 8 AM to 11 PM. Simply contact us via WhatsApp at +971 54 548 8731 to schedule a convenient appointment.
4. Will I receive genetic counseling with this test?
Yes. Pre-test genetic counseling is mandatory to construct a detailed family pedigree and discuss the implications of possible results. Post-test telephonic guidance is also provided to help you and your family understand the clinical significance of the findings.
UAE Regulatory & Data Privacy Adherence
Regulatory Compliance & Data Protection
- Data Privacy: All genetic data is processed in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL), ensuring your genomic information is securely handled and stored.
- Health Data Governance: This service adheres to Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields, governing the secure transmission and management of digital health records.
- Medical Liability & Consent: Patient safety and informed consent are managed in accordance with Federal Decree-Law No. 4 of 2016 on Medical Liability.
- Laboratory Accreditation: DNA Labs UAE operates under DHA Facility License No. 1143 and is ISO 9001:2015 Certified (Cert: INT/EGQ/2509DA/3139).
Clinical & Logistical Metadata
| Test Name | LRP2 Gene Donnai-Barrow Syndrome Genetic Test (NGS) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Whole Blood, FTA Card Blood Spot, or Extracted DNA |
| Methodology Used | Next-Generation Sequencing (NGS) – Full LRP2 Coding Region |
| ICD-10-CM Code | Q87.8 |
| LOINC Code | 81247-9 |
| DHA Facility License & Address | License: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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