Test Price
2,800 AED✅ Home Collection Available
MTHFR Gene Mutation & Homocystinuria Genetic Test in UAE | 2800 AED
Executive Summary & Core Metrics
This MTHFR gene test utilises next-generation sequencing (NGS) to analyse the full coding region of the MTHFR gene, achieving a 99.9% diagnostic sensitivity for pathogenic variants associated with homocystinuria and elevated thrombotic risk. The service includes DHA-licensed genetic counselling, a comprehensive digital report with clinical interpretation, and optional VIP mobile phlebotomy with temperature-controlled cold-chain home collection available daily from 8 AM to 11 PM.
Test Overview & Methodology
The MTHFR Gene NGS Test provides complete sequencing of the MTHFR gene to detect single nucleotide variants, insertions, and deletions linked to homocystinuria and hypercoagulable states. Unlike targeted SNP genotyping, which covers only common variants, our full-gene approach ensures comprehensive mutation detection for accurate risk stratification.
| Feature | Our Test (DHA-Approved) | Closest Alternative |
|---|---|---|
| Methodology | Full NGS (Next‑Generation Sequencing) | Targeted SNP genotyping only |
| Diagnostic Sensitivity | 99.9% for all pathogenic variants | ≈70% (common variants only) |
| Turnaround Time | 3 – 4 Weeks (report with DHA interpretation) | 4 – 6 Weeks |
Physician Insight & Safety Protocols
A Note from Consultant Medical Genetics Lina Osama Zaki Quteineh (DHA: 9294403)
“As a consultant medical geneticist, I advise that an MTHFR gene test result must always be evaluated alongside the full clinical history, family pedigree, and plasma homocysteine levels. It is essential not to alter or discontinue prescribed anticoagulation or B-vitamin therapy based solely on this genetic report. Please discuss all findings with a UAE-licensed specialist to develop a safe, personalised preventive health strategy.”
Medication & Clinical Advisory
⚠ Do not stop or modify any prescribed medication, including blood thinners or vitamin supplements, without prior consultation with your treating physician. This test is a diagnostic aid and does not replace clinical judgment.
Safety Exclusion Criteria & Red Flags
- Acute thromboembolic event requiring immediate emergency care – do not delay.
- Patients currently on anticoagulation therapy must only test under specialist supervision.
- This test is not a substitute for metabolic newborn screening in suspected homocystinuria.
- Individuals unable to provide informed consent for genetic testing (a UAE-licensed genetic counsellor must be involved).
Patient FAQ & Clinical Guidance
1. What does an MTHFR gene mutation mean for my vascular health?
An MTHFR mutation can reduce your body’s ability to process homocysteine, potentially raising the risk of blood clots, stroke, or heart disease – but not everyone with a mutation will develop these conditions. The NGS analysis provides a complete mutation map so your physician can assess your personal risk, recommend targeted homocysteine monitoring, and advise on folate-based interventions. Clinical correlation with a DHA‑licensed internist or preventive cardiologist is essential.
2. How is the home blood collection performed, and is it safe?
A trained DHA‑certified phlebotomist arrives at your location between 8 AM and 11 PM using a validated cold‑chain kit; the whole process takes under 10 minutes and follows ISO‑certified infection control protocols. You can provide a whole blood sample, extracted DNA, or a single drop on an FTA card. Once collected, the specimen is transported at 2–8°C to our genomics lab, ensuring integrity for NGS. You receive a digital tracking link and same‑day confirmation.
3. How are my genetic data protected under UAE law?
Your genetic information is processed and stored in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All results are encrypted and accessible only to you and your designated healthcare provider. We never share your data with third parties without your explicit written consent.
UAE Regulatory & Data Privacy Adherence
Your Data, Your Rights – Governed by UAE Federal Law
DNA Labs UAE operates in strict adherence to the Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All genetic testing procedures and patient consent protocols are conducted in accordance with Federal Decree-Law No. 4 of 2016 on Medical Liability. Your clinical data is encrypted, securely stored, and accessible only to you and your authorised physician. We maintain ISO 9001:2015 certification for quality management and undergo regular DHA compliance audits.
Clinical & Logistical Metadata
| Test Name | MTHFR Gene Mutation & Homocystinuria Genetic Test |
| Price (AED) | 2800 |
| Turnaround Time | 3 – 4 Weeks |
| Sample Type / Matrix | Whole Blood, Extracted DNA, or FTA Card |
| Methodology Used | Full NGS (Next‑Generation Sequencing) |
| ICD-10-CM Code | E72.11 (Homocystinuria) |
| LOINC Code | 21636-6 (MTHFR gene mutation analysis) |
| DHA Facility License & Address | DHA License: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians