Test Price
2,800 AED✅ Home Collection Available
GCK Gene Hyperinsulinemic Hypoglycemia Type 3 Genetic Test in UAE | 2800 AED | 2026 DHA Guidelines
تحليل تسلسل الحمض النووي لجين GCK المرتبط بفرط الأنسولينية ونقص سكر الدم من النوع الثالث في الإمارات | 2800 درهم | معتمد من هيئة الصحة بدبي
Executive Summary
نحن نقدم أعلى معايير الدقة والأمان وفقًا للمرسوم بقانون اتحادي رقم 41 لسنة 2024 والتشريعات الصحية في دولة الإمارات، مع حماية كاملة للبيانات الجينية طبقًا لقانون حماية البيانات الشخصية الإماراتي.
Overview / نظرة عامة
The GCK gene test identifies pathogenic variants causing hyperinsulinemic hypoglycemia type 3 (familial hyperinsulinism), an inherited metabolic disorder characterized by excessive insulin secretion and dangerously low blood sugar. This next-generation sequencing (NGS) analysis examines the entire coding region of the GCK gene with unmatched depth, enabling precise diagnosis and guiding personalized dietary or pharmacological management. يتم إجراء هذا التحليل المتقدم باستخدام تقنية تسلسل الجيل التالي لتقديم تشخيص دقيق يساعد الأطباء في وضع خطة علاجية مخصصة.
| Feature | Our Test (NGS) | Sanger Sequencing (Alternative) |
|---|---|---|
| Methodology | Next-Generation Sequencing (NGS) – full gene analysis | Single gene fragment analysis per reaction |
| Clinical Sensitivity | >99% for all GCK coding variants | ~85% (may miss large deletions/duplications) |
| Turnaround Time | 3 to 4 Weeks | 6 to 8 Weeks |
| ISO Accreditation | ISO 9001:2015 (Cert: INT/EGQ/2509DA/3139) | Varies; often not certified |
Pre-Test Information / معلومات ما قبل التحليل
- A comprehensive clinical history of the patient, including documentation of hypoglycemic episodes and family history of metabolic disorders, is mandatory. مطلوب تاريخ سريري شامل للمريض يشمل نوبات نقص السكر والتاريخ العائلي.
- A pre-test genetic counselling session is required to draw a detailed pedigree chart of family members affected with Hyperinsulinemic hypoglycemia type 3. جلسة استشارة وراثية قبل الفحص لتخطيط شجرة العائلة.
- No fasting is strictly necessary for the DNA sample, but follow any specific instructions from your physician. الصيام غير مطلوب عادة.
- Approved sample types: Whole Blood (EDTA tube), Extracted DNA, or one drop of blood on an FTA card. العينات المقبولة: دم كامل أو حمض نووي مستخلص أو قطرة دم على بطاقة FTA.
Physician Insight & Safety Protocol
“This genetic test provides molecular confirmation of a condition that can often mimic other metabolic or neurological disorders. I strongly advise that results be interpreted within the full clinical picture, including glucose and insulin levels, and not in isolation. As an Endocrinologist, I see how early, precise diagnosis empowers families with actionable strategies and reduces unnecessary interventions.”
— Dr. PRABHAKAR REDDY, DHA License: 61713011
⚠ Medication Warning
Do not discontinue prescribed medication without consulting your doctor. Genetic test results are not a substitute for ongoing medical supervision. Abrupt cessation of diazoxide, octreotide, or other hypoglycemia medications can precipitate life-threatening hypoglycemia.
🛑 Exclusion Criteria & Emergency Red Flags
Exclusion Criteria:
- Minors (under 18 years) without documented parental/legal guardian consent (per UAE CDS Law 2026, Art. 87). موافقة ولي الأمر إلزامية للقصر.
- Individuals who have not received pre-test genetic counselling, as mandated by UAE healthcare regulations.
- Patients unwilling to share relevant clinical history necessary for result interpretation.
- Any condition that contraindicates venous blood draw (e.g., severe coagulopathy without medical clearance).
ER Red Flags – Seek Immediate Medical Attention:
- Severe hypoglycemia (blood glucose below 50 mg/dL) with loss of consciousness or seizures.
- Symptoms of neuroglycopenia: confusion, blurred vision, slurred speech, or inability to wake.
- Rapid weight loss, persistent vomiting, or lethargy in a child with known hyperinsulinism.
Patient FAQ & Clinical Guidance
1. What is the GCK gene hyperinsulinemic hypoglycemia type 3 test, and why is it performed?
This detects disease-causing mutations in the GCK gene to confirm congenital hyperinsulinism, enabling tailored treatment and accurate family screening.
It analyzes the entire GCK gene using next-generation sequencing, looking for single nucleotide variants, small insertions/deletions, and copy number changes that cause unregulated insulin release. Confirming the genetic subtype helps differentiate from other forms of hypoglycemia and guides the use of medications like diazoxide or surgical intervention. A positive result also allows cascade testing of family members.
يكشف تحليل جين GCK عن الطفرات المسببة لفرط الأنسولينية الخلقي من النوع الثالث، مما يساعد في تأكيد التشخيص ووضع خطة علاجية دقيقة وفحص أفراد الأسرة المعرضين.
2. How is the sample collected, and do I need to prepare?
A simple blood draw from your arm or a finger‑prick onto an FTA card is all that’s required, with no fasting or special preparation needed.
Our certified phlebotomist will collect the sample at your home or office between 8 AM and 11 PM, using sterile, temperature‑controlled transport to preserve DNA integrity. You should continue all prescribed medications unless your doctor advises otherwise. Ensure you have your Emirates ID and any prior genetic reports ready for the logistics team.
يتم جمع العينة بسحب دم بسيط أو قطرة على بطاقة خاصة، دون الحاجة للصيام أو تحضيرات خاصة. نقدم خدمة جمع منزلي من 8 صباحاً وحتى 11 مساءً.
3. When will I receive my results, and how do I understand them?
Results are ready within 3 to 4 weeks and include a detailed clinical interpretation by our genetic counsellors and a free telephonic consultation with a physician.
You will receive a secure digital report listing any identified GCK variants classified by pathogenicity (pathogenic, likely pathogenic, uncertain significance). A follow‑up session with a specialist explains the implications for your health, reproductive risks, and monitoring needs. For ambiguous findings, further family studies may be recommended at no additional cost for two relatives.
تظهر النتائج خلال 3 إلى 4 أسابيع مع تفسير مفصل واستشارة هاتفية مجانية. التقرير يوضح الطفرات الجينية وتصنيفها وأهميتها السريرية.
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