Test Price
3,500 AEDโ Home Collection Available
Human Exome Sequencing (Twist Core Exome Panel) in UAE | 3500 AED | DHA Licensed Facility
Executive Summary & Core Metrics
- โAccuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited NGS Processing (Cert: INT/EGQ/2509DA/3139).
- โPremium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM).
- โClinical Guidance: Complimentary Telephonic Post-Test Clinical Correlation Session with DHA-Licensed Genetic Counselors.
- โInsurance: Direct Billing Verification via WhatsApp at +971 54 548 8731. All major UAE insurers accepted.
Test Overview & Methodology
Human Exome Sequencing via the Twist Human Core Exome Panel is a comprehensive next-generation sequencing (NGS) assay that targets all protein-coding regions (exons) across the human genome โ approximately 33 megabases of curated clinical content. This test identifies pathogenic single-nucleotide variants (SNVs), insertions/deletions (indels), and copy number variations (CNVs) with exceptional depth and uniformity, enabling precise diagnosis of hereditary cancers, inborn errors of metabolism, neurodevelopmental disorders, and rare genetic syndromes. In the UAE, this 3500 AED panel is processed through an ISO 9001:2015-certified facility under DHA License 1143 with a 5-week turnaround time.
| Parameter | Our Test โ Twist Core Exome | Closest Alternative โ Conventional WES |
|---|---|---|
| Target Enrichment | Twist Bioscience Double-Stranded Capture Probes โ Uniform Coverage, Minimal GC Bias | Solution-phase hybridization; variable uniformity, higher duplication rates |
| Diagnostic Yield | โฅ99.9% Sensitivity for SNVs/Indels; Superior CNV Detection | ~97โ98% Sensitivity; CNV detection often limited or absent |
| Turnaround Time | 5 Weeks (Expedited Reporting Available) | 6โ10 Weeks |
| ISO Accreditation | ISO 9001:2015 Certified (INT/EGQ/2509DA/3139) | Often Uncertified or Self-Declared |
| DHA Compliance | Full DHA/MOHAP Regulatory Adherence; UAE PDPL Compliant | Variable; May Lack UAE-Specific Data Governance |
| Price (UAE) | 3500 AED (Insurance Direct Billing Available) | 2800โ5000 AED (Often Out-of-Pocket) |
Physician Insight & Safety Protocols
"Exome sequencing provides a high-resolution view of the protein-coding genome, yet each result must be contextualized within the patient's full clinical presentation. A negative report does not eliminate the possibility of a genetic disorder โ it indicates that no known pathogenic variant was identified in the exonic regions using current analytical pipelines. I strongly advise all patients to review their findings with a DHA-licensed clinical geneticist. This test is a complementary diagnostic tool and should never replace a thorough clinical evaluation."
โ Lina Osama Zaki Quteineh, Consultant Medical Genetics | DHA Registration ID: 9294403
Medication Advisory
DO NOT DISCONTINUE PRESCRIBED MEDICATION WITHOUT CONSULTING YOUR DOCTOR.
Genetic findings may include incidental variants that are not directly related to the primary clinical question. Never adjust your treatment regimen based solely on sequencing data without formal consultation with your referring physician and a qualified genetic counselor.
Exclusion Criteria & Emergency Red Flags
- Exclusion: This test is not intended for acute emergency diagnosis, rapid prenatal decision-making, or standalone forensic identification.
- Exclusion: Patients who have received allogeneic bone marrow transplantation within the past 6 months may yield donor-derived DNA confounding results.
- Minors: Genetic testing of individuals under 18 years requires documented parental/guardian consent per UAE Federal Law No. 2 of 2019.
- ER Red Flag: If you are experiencing acute symptoms (seizures, loss of consciousness, severe pain, or respiratory distress), proceed to the nearest emergency department immediately โ do not wait for genetic test results.
- Data Privacy: All genomic data is stored and processed in compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL). Patients retain the right to request data deletion after reporting.
Patient FAQ & Clinical Guidance
1. What is Human Exome Sequencing and how does the Twist Core Exome Panel work?
Human exome sequencing decodes all protein-coding genes to identify hereditary disease-causing genetic variants accurately. The Twist Human Core Exome Panel uses proprietary double-stranded DNA capture probes to selectively enrich approximately 33 megabases of the human exome with industry-leading uniformity. Your extracted DNA or whole blood sample undergoes next-generation sequencing (NGS) on high-throughput platforms, followed by bioinformatic analysis aligned to the GRCh38 reference genome. Variants are classified according to ACMG/AMP 2026 guidelines, and a clinically actionable report is generated within 5 weeks. This test is particularly valuable for oncologists evaluating hereditary cancer syndromes, anti-aging specialists assessing longevity-related genetic markers, and medical researchers investigating rare disease etiology.
2. How should I prepare for the exome sequencing test in the UAE?
No fasting or medication changes needed; a routine blood draw provides sufficient DNA for exome analysis. For whole blood collection, our DHA-licensed mobile phlebotomist visits your home or office between 8 AM and 11 PM using ISO-certified cold-chain transport kits. If you are submitting previously extracted DNA, ensure it meets the minimum concentration of 50 ng/ยตL and a total yield of 1 ยตg with an OD 260/280 ratio between 1.8 and 2.0. There are no dietary restrictions, and you may continue all prescribed medications as directed by your physician. Please inform our team during booking if you have received any blood transfusions or bone marrow transplants within the past 6 months, as this may affect result interpretation. All samples are processed at our DHA-licensed facility (License: 1143) with full UAE PDPL data protection compliance.
3. What do my exome sequencing results mean and who will explain them?
Exome sequencing results require expert genetic counseling to interpret pathogenic variants and guide clinical decisions appropriately. Your report will classify identified variants into five tiers: Pathogenic, Likely Pathogenic, Variant of Uncertain Significance (VUS), Likely Benign, and Benign โ following ACMG/AMP 2026 standards. A VUS result is common and does not confirm or exclude disease; it may be reclassified as scientific knowledge evolves. For every test, we include a complimentary telephonic post-test consultation with a DHA-licensed genetic counselor who will walk you through your results in plain language. Your referring physician โ whether an oncologist, anti-aging specialist, or researcher โ will receive the full clinical report to integrate findings into your care plan. Incidental findings unrelated to the primary clinical question may be reported per your consent preferences documented during pre-test counseling.
UAE Regulatory & Data Privacy Adherence
DNA Labs UAE operates under the regulatory oversight of the Dubai Health Authority (DHA) and adheres to all applicable federal statutes governing medical diagnostics and patient data. All genomic data processing is conducted in strict compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical testing safety and patient consent protocols are governed by Federal Decree-Law No. 4 of 2016 on Medical Liability. Our laboratory holds ISO 9001:2015 certification (Cert: INT/EGQ/2509DA/3139), reflecting a commitment to international quality management standards. All genetic test results are encrypted, access-controlled, and retained only as long as required by UAE law.
Clinical & Logistical Metadata
| Test Name | Human Exome Sequencing (Twist Core Exome Panel) |
| Price (AED) | 3500 AED |
| Turnaround Time | 5 Weeks (Expedited Reporting Available) |
| Sample Type / Matrix | Whole Blood or Extracted DNA (โฅ50 ng/ยตL, OD 260/280 1.8โ2.0, total yield โฅ1 ยตg) |
| Methodology Used | Next-Generation Sequencing (NGS) โ Twist Human Core Exome Panel, double-stranded capture probe enrichment, Illumina high-throughput platform, GRCh38 alignment, ACMG/AMP variant classification |
| ICD-10-CM Code | Z13.71 |
| LOINC Code | 84473-7 |
| DHA Facility License & Laboratory Address | License No. 1143 โ Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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All reports reviewed by DHA-Certified physicians