Test Price
3,500 AED✅ Home Collection Available
Whole Exome Sequencing (WES) with Variant Calling & Annotation in UAE | 2500 AED | Diagnostic Genetic Test
Executive Summary – Core Metrics
- ✓ Price: 2,500 AED (Direct Billing Verification via WhatsApp +971 54 548 8731)
- ✓ Turnaround Time: 28 calendar days from sample receipt
- ✓ Sample Type: Peripheral whole blood (EDTA) or extracted gDNA – VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily (8 AM – 11 PM)
- ✓ Accuracy Guarantee: ≥100× mean coverage on Illumina platform – GATK-based variant calling with ACMG/AMP 5-tier classification
- ✓ Post-Test Guidance: Complimentary telephonic clinical interpretation session with a DHA-licensed consultant
Test Overview & Methodology
Whole Exome Sequencing (WES) provides comprehensive analysis of all ~20,000 protein-coding genes, identifying pathogenic and likely pathogenic variants associated with rare inherited disorders, neurological conditions, and undiagnosed syndromes. The process utilizes Illumina sequencing chemistry with ≥100× mean coverage, followed by GATK best-practices variant calling and functional annotation via Ensembl VEP. All clinically significant variants are interpreted against current ACMG/AMP standards and correlated with the patient's phenotype.
| Parameter | Our Service – DNA Labs UAE | Alternative Service |
|---|---|---|
| Sequencing Depth | ≥100× mean coverage (Illumina platform) | ~50× coverage |
| Variant Calling & Annotation | GATK-based, ACMG/AMP 5-tier classification, Ensembl VEP | Basic annotation limited to public databases |
| Turnaround Time | 4 weeks from sample receipt | 6–8 weeks |
| Reporting | Clinical Exome Report with DHA-compliant interpretation | Research-grade VCF without clinical correlation |
Physician Insight & Safety Protocols
"Whole exome sequencing provides a powerful molecular lens for diagnosing complex genetic conditions. However, the data requires careful integration with the patient's full clinical history and family pedigree to avoid misinterpretation of variants of uncertain significance. I always emphasize that this test is a tool, not a final verdict."
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Important Clinical Advisory
Genetic results may indicate a predisposition or confirm a diagnosis. Never discontinue, start, or modify any medication or treatment based solely on preliminary genetic findings without explicit consultation with your referring physician or a qualified genetic counselor.
Exclusion Criteria & Emergency Red Flags
- Not indicated for: Healthy individuals without clinical suspicion of a monogenic disorder or those with a clear, well-characterized single-gene diagnosis pathway.
- Not a substitute for: Targeted single-gene testing when the phenotype is strongly suggestive of a specific disorder.
- Emergency red flags: Acute worsening of symptoms, sudden severe pain, difficulty breathing, or any new neurological deficit requires immediate evaluation at the nearest emergency department, regardless of pending test results.
Patient FAQ & Clinical Guidance
1. What is whole exome sequencing used for?
Whole exome sequencing is a genetic test that reads the protein-coding regions of your DNA (the exome). It is primarily used to identify the genetic cause of rare, undiagnosed conditions, developmental delays, multiple congenital anomalies, and inherited neurological disorders.
2. How long does it take to get results?
Results are typically available within 28 calendar days from the date the laboratory receives your blood sample. This timeline includes sequencing, bioinformatics analysis, and clinical variant interpretation.
3. Is genetic testing covered by insurance in Dubai?
Coverage varies by insurer and policy. Many UAE health insurance providers now include clinical exome sequencing when deemed medically necessary by a specialist. Please contact our billing team via WhatsApp at +971 54 548 8731 for a direct verification with your insurance company.
4. Can I do this test if I am asymptomatic?
Whole exome sequencing is designed for individuals with a clinical indication of a genetic disorder. It is not recommended as a general wellness or carrier screening test for healthy, asymptomatic adults. Please consult with a genetic specialist to see if this test is appropriate for you.
UAE Regulatory & Data Privacy Adherence
UAE Health Data Protection & Patient Privacy
- Data Security: All genetic data is processed and stored in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL).
- Healthcare IT Standards: Laboratory information systems and data handling adhere to Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
- Informed Consent & Safety: Sample collection and genetic testing procedures abide by Federal Decree-Law No. 4 of 2016 on Medical Liability, ensuring patient safety and informed consent.
Clinical & Logistical Metadata
| Test Name | Whole Exome Sequencing (WES) with Variant Calling & Annotation |
| Price (AED) | 2,500.00 AED |
| Turnaround Time | 28 calendar days (4 weeks) from sample receipt |
| Sample Type / Matrix | Peripheral whole blood (EDTA) – VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection |
| Methodology Used | Illumina Next-Generation Sequencing, GATK Best Practices, Ensembl VEP, ACMG/AMP Clinical Interpretation |
| ICD-10-CM Code | Z01.81, Z01.89 |
| LOINC Code | 93927-4 |
| DHA Facility License & Laboratory Address | DHA License No: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | Corporate Lab Branding: DNA Labs UAE |
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