Test Price
2,800 AED✅ Home Collection Available
COL3A1 Gene Ehlers-Danlos Syndrome Type 4 (vEDS) Genetic Test in UAE | 2,800 AED | DHA Licensed
Executive Summary & Core Metrics
Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 accredited processing (Cert: INT/EGQ/2509DA/3139). Our Next-Generation Sequencing (NGS) protocol includes coverage of the entire COL3A1 coding region and splice junctions, with confirmation of pathogenic variants by Sanger sequencing.
Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM across the UAE. Safe transport of peripheral whole blood, extracted DNA, or a single drop on an FTA card.
Clinical Guidance: Telephonic Post-Test Clinical Guidance for result interpretation. Our genetic counsellor will walk you through the report and discuss proactive surveillance and family planning next steps.
Insurance: Direct Billing Verification via WhatsApp at +971 54 548 8731. We coordinate with major UAE insurers to confirm coverage prior to sample collection.
Test Overview & Methodology
The COL3A1 NGS test screens for pathogenic mutations in the COL3A1 gene, the sole cause of vascular Ehlers-Danlos syndrome (vEDS, type IV). This life-threatening connective tissue disorder predisposes to arterial, intestinal, and uterine rupture. Definitive molecular diagnosis through full gene sequencing is critical for initiating proactive vascular surveillance and informing family screening.
| Feature | Our Test (NGS) | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Methodology | Next-Generation Sequencing (full gene coding region & splice junctions) | Single-exon / targeted Sanger sequencing |
| Turnaround Time | 3–4 weeks | 6–8 weeks |
| Diagnostic Sensitivity | >99.9% for SNVs and small indels | High for known familial variants, incomplete gene coverage for novel findings |
| Price | 2,800 AED | ~3,500 AED (variable) |
| Sample Types | Peripheral Whole Blood, Extracted DNA, FTA Card Spot | Blood only |
Physician Insight & Safety Protocols
“As a Consultant Medical Genetics specialist, I recognize the profound implications of a potential vascular Ehlers-Danlos syndrome diagnosis. This COL3A1 genetic test provides definitive molecular evidence, but it must be carefully integrated with the patient's full clinical history, family pedigree, and physical examination findings. I strongly recommend a formal post-test genetic counselling session to fully understand the implications for you and your family members.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics | DHA Registration ID: 9294403
⚠️ Medication Warning: Do not discontinue prescribed medication, especially blood pressure regulators or antiplatelets, without consulting your doctor. Abrupt cessation can precipitate vascular events.
Exclusion Criteria & Emergency Red Flags
- Exclusion: Active bleeding disorder or current use of anticoagulants (inform the phlebotomist). Recent major surgery (<4 weeks).
- Emergency Red Flags: Sudden, severe chest or abdominal pain, acute shortness of breath, stroke-like symptoms (facial droop, limb weakness), or massive bruising without trauma. Seek immediate emergency care.
- Minors: Genetic testing for minors requires parental/guardian consent and a clinical genetics consultation, in compliance with Federal Decree-Law No. 4 of 2016 on Medical Liability.
Patient FAQ & Clinical Guidance
1. What is the purpose of the COL3A1 genetic test?
Answer: The COL3A1 genetic test identifies disease-causing mutations in the COL3A1 gene responsible for vascular Ehlers-Danlos syndrome (vEDS). Results can confirm a clinical diagnosis, guide surveillance for vascular complications, and inform family screening. A formal genetic counselling session is required before testing to draw a detailed pedigree and ensure informed consent.
2. How is the sample collected for this test?
Answer: Sample collection requires only a standard peripheral blood draw or a single drop on an FTA card. Our VIP mobile phlebotomist visits your home or office using a temperature-controlled cold-chain kit to ensure sample stability. No fasting is required, and the procedure takes less than 10 minutes. Collections are available daily from 8 AM to 11 PM.
3. What do my results mean?
Answer: A positive genetic result confirms vascular Ehlers-Danlos syndrome type IV caused by a pathogenic COL3A1 mutation. It means you carry a variant that significantly increases your lifetime risk for arterial dissection, organ rupture, and other complications. A negative result substantially reduces the likelihood of vEDS but does not rule out other forms of Ehlers-Danlos syndrome. A post-test genetic counselling session will help you interpret your specific results and plan appropriate medical surveillance.
UAE Regulatory & Data Privacy Adherence
Compliance & Data Protection Framework
DNA Labs UAE operates under DHA Facility License Number 1143, strictly adhering to the highest standards of medical data protection and patient privacy as mandated by UAE federal law.
- Data Privacy: Fully compliant with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL).
- Health Data Governance: Adheres to Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
- Medical Liability & Consent: All clinical testing, patient consent, and safety protocols follow Federal Decree-Law No. 4 of 2016 on Medical Liability.
- Accreditation: ISO 9001:2015 certified processing (Cert: INT/EGQ/2509DA/3139) ensuring rigorous quality management.
Clinical & Logistical Metadata
| Test Name | COL3A1 Gene Ehlers-Danlos Syndrome Type 4 (vEDS) Genetic Test |
| Price (AED) | 2,800 |
| Turnaround Time | 3–4 weeks |
| Sample Type / Matrix | Peripheral Whole Blood, Extracted DNA, or FTA Card Spot |
| Methodology Used | Next-Generation Sequencing (NGS) with Sanger Confirmation |
| ICD-10-CM Code | Q79.6 |
| LOINC Code | 21643-2 |
| DHA Facility License & Address | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | License: 1143 |
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All reports reviewed by DHA-Certified physicians