Test Price
2,800 AED✅ Home Collection Available
TRMU Gene Mitochondrial Modifier of Deafness Genetic Test in UAE | 2,800 AED
Executive Summary & Core Metrics
High‑confidence genomic assessment of the TRMU gene to identify pathogenic mitochondrial variants associated with hereditary sensorineural hearing loss. This test delivers 99.9% diagnostic sensitivity via ISO 9001:2015 certified next‑generation sequencing.
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Certified Next‑Generation Sequencing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature‑Controlled Cold‑Chain Home Collection (Available daily from 8 AM to 11 PM).
- Clinical Guidance: Telephonic post‑test clinical interpretation of results with a specialist genetic counsellor.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The TRMU gene encodes a mitochondrial tRNA‑modifying enzyme essential for normal auditory function. Pathogenic variants disrupt mitochondrial protein synthesis, increasing susceptibility to sensorineural hearing loss. This test employs next‑generation sequencing (Illumina™) to interrogate the full coding region, splice‑site boundaries, and flanking intronic regions, with Sanger confirmation of all clinically significant findings.
| Feature | Our TRMU NGS Test | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Precision | 99.9% sensitivity, full coding region coverage + splicing sites | Lower sensitivity for mosaicism; only known hotspots analysed |
| Methodology | Next‑Generation Sequencing (Illumina™), confirmed by Sanger | Capillary electrophoresis (Sanger) only |
| Turnaround Time | 21 to 28 Days (3 to 4 Weeks) | 4 to 6 Weeks |
Physician Insight & Safety Protocols
“A positive TRMU variant indicates an elevated risk for mitochondrial‑mediated hearing impairment, yet it does not guarantee progression to clinically significant loss. Conversely, a negative result does not exclude other genetic or environmental aetiologies. All findings must be interpreted within the full context of audiometric evaluation, family history, and clinical examination. I strongly recommend a multidisciplinary review involving a clinical geneticist and an otolaryngologist before any therapeutic decisions are made.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Clinical Advisory – Medication and Device Continuity
⚠️ Do not discontinue any prescribed medication, hearing aid, or cochlear implant therapy without explicit instruction from your treating physician.
Genetic test results are one component of a comprehensive diagnostic workup. Abrupt cessation of therapy may lead to irreversible auditory decline. Always consult your specialist before modifying any management plan.
Exclusion Criteria & Urgent Referral Indicators
- Exclusion Criteria: Individuals currently undergoing chemotherapy that may interfere with DNA extraction; pregnant women seeking prenatal diagnosis without prior specialist genetic counselling and informed consent; minors (under 18) without parental or guardian consent as mandated by UAE Federal Decree‑Law No. 4 of 2016 on Medical Liability.
- Emergency Red Flags: Sudden, complete sensorineural hearing loss; acute vertigo with nausea; rapidly progressive tinnitus — these symptoms require immediate otolaryngologic evaluation, not genetic testing alone.
Patient FAQ & Clinical Guidance
1. What is the TRMU gene test and what conditions does it evaluate?
The TRMU gene test uses next‑generation sequencing to detect pathogenic mitochondrial variants linked to hereditary sensorineural hearing loss. It primarily assesses susceptibility to non‑syndromic and syndromic forms of deafness caused by mitochondrial dysfunction.
2. How is the sample collected and what logistics are involved?
A certified phlebotomist collects a standard peripheral whole blood sample during a scheduled home visit. The specimen is transported via temperature‑controlled cold‑chain logistics to our ISO‑certified laboratory. VIP Mobile Phlebotomy is available daily from 8 AM to 11 PM.
3. What is the turnaround time for results and how will I receive them?
Results are delivered within 21 to 28 days (3 to 4 weeks) from sample receipt. You will receive a comprehensive report via secure electronic delivery, followed by a telephonic consultation with a specialist genetic counsellor to interpret the findings.
4. Does insurance cover this test and how can I verify my coverage?
Yes, we work with major UAE insurers for direct billing. Send your insurance details via WhatsApp to +971 54 548 8731 and our team will confirm your coverage and any applicable co‑payments before the test.
UAE Regulatory & Data Privacy Adherence
This facility operates in full compliance with UAE Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All genetic data are encrypted, access‑controlled, and processed exclusively for diagnostic purposes with your explicit consent. Clinical safety and patient consent protocols adhere to Federal Decree‑Law No. 4 of 2016 on Medical Liability.
Clinical & Logistical Metadata
| Test Name | TRMU Gene Mitochondrial Modifier of Deafness Genetic Test (NGS) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 21 to 28 Days (3 to 4 Weeks) |
| Sample Type / Matrix | Peripheral Whole Blood — VIP Mobile Phlebotomy & Temperature‑Controlled Cold‑Chain Home Collection (Available daily from 8 AM to 11 PM) |
| Methodology Used | Next‑Generation Sequencing (Illumina™) with Sanger Confirmation |
| ICD-10-CM Code | H90.5, H90.3, Z15.89 |
| LOINC Code | 82121-5 |
| DHA Facility License & Laboratory Address | DHA Facility License Number: 1143 — Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE — DNA Labs UAE |
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All reports reviewed by DHA-Certified physicians