Test Price
2,800 AED✅ Home Collection Available
GJB6 Gene Autosomal Dominant Deafness Type 3B (DFNA3B) Genetic Test in UAE | 2800 AED
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 15189 & ISO 9001:2015 Accredited Processing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (8 AM – 11 PM) for peripheral blood samples.
- Clinical Guidance: Telephonic Post-Test Clinical Guidance for result interpretation by DHA-licensed genetic counsellor.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
GJB6 gene sequencing identifies pathogenic variants causing autosomal dominant nonsyndromic hearing loss (DFNA3B), enabling precise diagnosis, family screening, and genetic counseling. The test employs next-generation sequencing (NGS) of the entire coding region and intron-exon boundaries, with deletion/duplication analysis via multiplex ligation-dependent probe amplification (MLPA). Confirmatory Sanger sequencing is performed for all clinically significant variants.
| Feature | Our Test – GJB6 NGS | Closest Alternative – Targeted Mutation Analysis |
|---|---|---|
| Precision | Full gene sequencing with 99.9% sensitivity and deletion/duplication detection | Limited to a predefined set of known mutations; lower detection rate |
| Methodology | Next‑Generation Sequencing (NGS) + confirmatory Sanger | Sanger sequencing of selected exons only |
| Turnaround Time | 3 to 4 weeks | 2 to 3 weeks |
Physician Insight & Safety Protocols
“As a Consultant Medical Genetics, I emphasize that GJB6 genetic testing must be interpreted in the context of comprehensive audiological evaluation and detailed family history. A positive result confirms the diagnosis of autosomal dominant deafness type 3B but does not predict the severity or rate of hearing loss progression. Genetic counseling is strongly recommended for all carriers and their families to guide reproductive decisions and early intervention.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory – Medication Awareness
Inform your doctor of all current medications, supplements, or herbal remedies before the test. Do not discontinue any prescribed treatment without consulting your physician. Genetic test results may have implications for medication response; however, this test does not directly assess drug metabolism. Continue all treatments as directed until otherwise advised by your healthcare provider.
Safety Exclusion & Emergency Red Flags
Exclusion Criteria:
- Individuals under 18 years without legal guardian consent.
- Inability to provide an adequate peripheral blood sample (minimum 2 mL whole blood in EDTA).
- Recent blood transfusion (within 2 weeks) may interfere with germline DNA analysis.
Emergency Red Flags – Seek Immediate Medical Attention:
- Sudden sensorineural hearing loss (over hours to days).
- Acute vertigo with nausea or vomiting.
- Ear trauma, head injury, or discharge of blood from the ear.
- This test is not designed for acute or emergency conditions.
Patient FAQ & Clinical Guidance
1. What is the GJB6 gene test?
The GJB6 gene test uses next-generation sequencing (NGS) to detect pathogenic variants in the connexin 30 gene, which are responsible for autosomal dominant nonsyndromic hearing loss (DFNA3B). It provides a definitive genetic diagnosis, enabling accurate family screening and genetic counseling.
2. How is the sample collected?
A peripheral blood sample (2–5 mL whole blood in EDTA) or a buccal swab is collected by a certified phlebotomist during a scheduled VIP mobile home visit. The sample is transported in a temperature-controlled cold chain to our ISO-accredited laboratory. Home collection is available daily from 8 AM to 11 PM.
3. What is the turnaround time?
Results are typically available within 3 to 4 weeks from the date the sample is received at our laboratory. Complex cases requiring additional confirmation may require up to 5 weeks. You will be contacted by a genetic counselor to discuss the results and their clinical implications.
UAE Regulatory & Data Privacy Adherence
This test is performed in full compliance with the UAE’s data protection and health information security regulations. All patient data is handled according to Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical safety and patient consent processes adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability. Our laboratory is DHA-licensed and committed to the highest standards of privacy and confidentiality.
Clinical & Logistical Metadata
| Test Name | GJB6 Gene Autosomal Dominant Deafness Type 3B (DFNA3B) Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3 to 4 weeks |
| Sample Type / Matrix | Peripheral whole blood (EDTA) or buccal swab |
| Methodology Used | Next‑Generation Sequencing (NGS) + confirmatory Sanger sequencing; deletion/duplication analysis by MLPA |
| ICD-10-CM Code | H90.3 (Sensorineural hearing loss, bilateral) |
| LOINC Code | 49211-0 (Genetic analysis of GJB6 gene) |
| DHA Facility License & Laboratory Address | License Number: 1143 – Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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