Test Price
2,800 AEDโ Home Collection Available
๐ Results in 15 โ 20 Business Days
TPM1 Gene Sequencing for Familial Hypertrophic Cardiomyopathy Type 3 (NGS) in UAE | 2800 AED | DHA Licensed
Executive Summary & Core Metrics
Diagnostic Precision & Service Excellence
This TPM1 sequencing test, performed at our DHA-licensed facility (License No. 1143), achieves 99.9% diagnostic sensitivity for familial hypertrophic cardiomyopathy type 3 using ISO 9001:2015-certified Next-Generation Sequencing. We offer VIP Mobile Phlebotomy with temperature-controlled cold-chain home collection daily from 8 AM to 11 PM, direct insurance verification via WhatsApp (+971 54 548 8731), and post-test clinical guidance by Consultant Medical Genetics Lina Osama Zaki Quteineh (DHA ID: 9294403).
Test Overview & Methodology
This test analyzes the entire TPM1 gene using next-generation sequencing to detect pathogenic variants linked to familial hypertrophic cardiomyopathy type 3. It provides a definitive diagnosis for patients and families at risk, guiding personalized cardiac management and surveillance. The methodology covers coding and regulatory regions, ensuring comprehensive variant detection.
| Feature | Our Test (NGS Full Gene) | Closest Alternative (Sanger Single Gene) |
|---|---|---|
| Methodology | Next-Generation Sequencing (NGS) | Sanger Sequencing (targeted) |
| Coverage | Entire gene (coding + regulatory regions) | Only selected exons / known mutations |
| Sensitivity | 99.9% | <95% for novel variants |
| Turnaround Time | 3 โ 4 Weeks | 6 โ 8 Weeks |
| Accreditation | ISO 9001:2015 (Cert: INT/EGQ/2509DA/3139) | Variable / Not guaranteed |
Physician Insight & Safety Protocols
Clinical Perspective โ Lina Osama Zaki Quteineh, Consultant Medical Genetics (DHA ID: 9294403):
Genetic test results for hypertrophic cardiomyopathy must be evaluated within the context of your personal and family cardiac history. A positive finding indicates an increased risk, not a certainty. I strongly recommend discussing all results with a certified genetic counselor to guide informed family screening and preventive strategies.
Advisory: Medication Continuity & Safety
Do NOT stop any prescribed cardiac or blood-thinning medication without consulting your treating physician. Abrupt discontinuation may precipitate life-threatening arrhythmias or heart failure.
Exclusion Criteria & Emergency Red Flags
- Recent blood transfusion (<2 weeks) or active systemic infection may affect DNA quality; please reschedule.
- Patients with acute decompensated heart failure or unstable angina should not undergo elective blood draws until stabilized.
- Urgent symptoms: If you experience sudden chest pain, fainting, or severe shortness of breath, seek emergency medical attention immediately โ do not wait for genetic results.
Patient FAQ & Clinical Guidance
1. What does the TPM1 gene test detect?
Direct answer: The test identifies pathogenic DNA variants in the TPM1 gene that cause familial hypertrophic cardiomyopathy type 3. It screens for mutations altering the tropomyosin protein, a key regulator of cardiac muscle contraction, which can lead to abnormal heart muscle thickening and electrical instability.
2. How should I prepare for the blood collection?
Direct answer: Avoid strenuous exercise for 24 hours and stay hydrated; no fasting is required. Our mobile phlebotomist will collect a small blood sample or an FTA card spot. Please have your Emirates ID and insurance card ready. A pre-test genetic counseling session is recommended to map your family pedigree.
3. How will my doctor use the results?
Direct answer: Results guide personalized screening, family planning, and targeted therapies for hypertrophic cardiomyopathy. A positive finding may prompt echocardiograms, Holter monitoring, or preventive medication for at-risk relatives. It also supports reproductive decisions through IVF with preimplantation genetic diagnosis.
UAE Regulatory & Data Privacy Adherence
Your genetic data privacy is protected under the Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical safety and patient consent protocols adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability. All laboratory processes are governed by ISO 9001:2015 certificate INT/EGQ/2509DA/3139.
Clinical & Logistical Metadata
| Test Name | TPM1 Gene Sequencing for Familial Hypertrophic Cardiomyopathy Type 3 (NGS) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 15 โ 20 Business Days |
| Sample Type / Matrix | Peripheral Whole Blood (FTA Card acceptable) |
| Methodology Used | Next-Generation Sequencing (NGS) โ Full Gene Coverage |
| ICD-10-CM Code | I42.1 (Obstructive hypertrophic cardiomyopathy), I42.2 |
| LOINC Code | 94212-9 |
| DHA Facility License & Address | Lic. 1143 โ Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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Available in Arabic, English, Hindi & Urdu
Preparation Required
["Avoid strenuous exercise for 24 hours", "Stay hydrated", "No fasting required"]
Medically Reviewed by Dr. Lina Osama Zaki Quteineh
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ISMS 27001:2022
ISO Accredited
HIPAA
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