Test Price
2,800 AED✅ Home Collection Available
PLN Gene Dilated Cardiomyopathy Type 1P (DCM1P) Genetic Test in UAE | 2,800 AED | DHA Licensed
Executive Summary & Core Metrics
Executive Summary
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Certified NGS Processing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Daily 8 AM – 11 PM).
- Clinical Guidance: Telephonic Post-Test Clinical Guidance for result interpretation.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The PLN gene encodes phospholamban, a key regulator of cardiac calcium cycling; pathogenic variants cause Dilated Cardiomyopathy Type 1P (DCM1P), often with high arrhythmic risk. This NGS‑based genetic test comprehensively sequences the entire coding region and canonical splice sites, detecting pathogenic or likely pathogenic variants according to ACMG guidelines. Results equip cardiologists and clinical geneticists to implement personalised management, lifelong surveillance, and family cascade screening.
| Feature | Our Test (DHA‑Licensed) | Closest Alternative |
|---|---|---|
| Precision | 30× average read depth, full gene NGS, ACMG variant interpretation | Targeted Sanger; may miss deep intronic or copy‑number variants |
| Methodology | Next‑Generation Sequencing (NGS) with orthogonal Sanger confirmation | Sanger Sequencing (single exon, lower throughput) |
| Speed | 21–28 Business Days | 14–28 Business Days (variable, often limited to hot‑spot regions) |
| Accreditation | ISO 9001:2015, DHA Facility License 1143 | Variable; not always UAE‑MOHAP recognised |
Physician Insight & Safety Protocols
Lina Osama Zaki Quteineh | Consultant Medical Genetics | DHA Registration ID: 9294403
“A positive PLN result can be life‑saving for families, enabling early intervention and cascade screening. However, a negative report does not fully exclude dilated cardiomyopathy. I always correlate genetic findings with echocardiographic data and three‑generation pedigree analysis. Prescribed cardiac therapy must never be altered without consulting your treating physician.”
Advisory: Medication Continuation & Clinical Supervision
Do not discontinue any prescribed cardiac medication — including beta‑blockers, ACE inhibitors, or diuretics — without explicit approval from your cardiologist. Abrupt cessation may precipitate acute decompensation or arrhythmic events.
Safety Exclusion Criteria & Emergency Red Flags
- Minors (under 18) require legal guardian consent per Federal Decree-Law No. 4 of 2016 on Medical Liability.
- Not intended for acquired non‑genetic cardiomyopathies (e.g., myocarditis, toxic cardiomyopathy, peripartum cardiomyopathy).
- This test should not be used as a standalone diagnostic instrument; clinical correlation with imaging and family history is mandatory.
- Emergency Red Flags: sudden chest pain, syncope, severe shortness of breath — proceed immediately to the nearest emergency department.
Patient FAQ & Clinical Guidance
1. What is the PLN gene and how does it cause dilated cardiomyopathy type 1P?
The PLN gene provides instructions for producing phospholamban, a protein that regulates calcium cycling in heart muscle cells. Pathogenic variants disrupt calcium homeostasis, leading to progressive cardiac dilation and reduced contractile function. This genetic form, designated DCM1P, often presents with high arrhythmic risk and variable penetrance within families.
2. How accurate is the NGS test for detecting PLN gene variants?
Analytical sensitivity exceeds 99% for single nucleotide variants and small insertions or deletions when coverage is adequate (≥30× mean read depth). All findings are interpreted using ACMG/AMP guidelines. A negative report does not exclude other genetic or acquired forms of cardiomyopathy; comprehensive clinical evaluation remains essential.
3. What sample types are accepted and is home collection available?
We accept whole blood, extracted DNA, or a single‑drop blood on FTA card. A temperature‑controlled, ISO‑certified VIP Mobile Phlebotomy service is available from 8 AM to 11 PM daily, ensuring specimen integrity via cold‑chain logistics. A completed requisition form and clinical history must accompany all samples.
4. What is the turnaround time and can I use insurance?
The standard report is delivered within 21–28 business days from receipt of a valid sample. Direct billing to major UAE insurers is supported; confirm eligibility via WhatsApp at +971 54 548 8731. Pre‑genetic counselling — including pedigree construction — is strongly advised to maximise clinical utility.
5. Should I stop my heart medications before or after the genetic test?
No. Continue all prescribed medications as directed by your physician. The genetic test requires only a standard blood or DNA sample and does not interfere with drug therapy. Never alter or discontinue cardiac treatment without consulting your cardiologist.
UAE Regulatory & Data Privacy Adherence
Data Protection & Health Information Governance
This test is performed in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All genetic data is encrypted, access‑controlled, and processed solely for diagnostic purposes. Patient consent and data handling procedures align with the DHA Data Protection Regulation. No genetic information is shared with third parties without explicit written authorisation.
Clinical & Logistical Metadata
| Test Name | PLN Gene Dilated Cardiomyopathy Type 1P (DCM1P) Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 21–28 Business Days |
| Sample Type / Matrix | Whole Blood, Extracted DNA, or FTA Card Blood Spot |
| Methodology Used | Next‑Generation Sequencing (NGS) with Orthogonal Sanger Confirmation |
| ICD-10-CM Code | I42.0 |
| LOINC Code | 81301-1 |
| DHA Facility License & Laboratory Address | DHA Facility License No. 1143 | DNA Labs UAE, Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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All reports reviewed by DHA-Certified physicians