Test Price
2,800 AED✅ Home Collection Available
NKX2-5 Gene Sequencing for Atrial Septal Defect with AV Conduction Defects – Genetic Test in the UAE | 2,800 AED | 2026 DHA Guidelines
تحليل جين NKX2-5 لعيوب الحاجز الأذيني واضطرابات التوصيل الأذيني البطيني في الإمارات | 2,800 درهم | معتمد من هيئة الصحة بدبي
Executive Summary — Clinical Excellence Guaranteed
الملخص التنفيذي: تحليل تسلسل شامل لجين NKX2-5 باستخدام تقنية الجيل التالي (NGS) للكشف عن الطفرات الجينية المرتبطة بعيوب الحاجز الأذيني واضطرابات التوصيل الأذيني البطيني. يُجرى هذا الاختبار في مختبر مرخص من هيئة الصحة بدبي (رقم الترخيص: 9834453) ومعتمد وفق معايير الآيزو 9001:2015 بموجب الشهادة رقم INT/EGQ/2509DA/3139. نضمن دقة تشخيصية تصل إلى 99.9% مع استشارة وراثية متكاملة بعد الفحص.
- ✓ Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO-Accredited NGS Processing with orthogonal Sanger confirmation of all clinically significant variants.
- ✓ Premium Logistics: Paid Hospital-Grade Home Collection via ISO-Certified Cold-Chain Home Collection and VIP Mobile Phlebotomy — available 8:00 AM to 11:00 PM across all Emirates.
- ✓ Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation provided by DHA-licensed molecular pathologists at no additional charge.
- ✓ Insurance: Direct Billing Verification via WhatsApp at +971 54 548 8731 — confirm your coverage before scheduling.
Overview
The NKX2-5 Gene NGS Test is a comprehensive molecular diagnostic assay that screens the entire coding region of the NKX2-5 homeobox transcription factor gene for pathogenic variants implicated in atrial septal defect (ASD) and atrioventricular (AV) conduction defects. This test is indicated for pediatric and adult patients presenting with congenital heart disease, familial ASD, or unexplained AV block. يكتشف هذا الاختبار الطفرات الجينية المسببة لعيوب القلب الخلقية المرتبطة بجين NKX2-5.
| Feature | Our Test — NGS Full Gene Sequencing | Closest Alternative — Single-Gene Sanger Sequencing |
|---|---|---|
| Methodology | Next-Generation Sequencing (NGS) with full coding region coverage ±20bp intronic boundaries | Sanger Sequencing — exon-by-exon, limited multiplexing |
| Variant Detection | SNVs, indels, and copy number variants (CNVs) — all exon-level resolution | SNVs and small indels only; CNV detection not feasible |
| Turnaround Time | 3 to 4 Weeks | 6 to 8 Weeks |
| Diagnostic Yield | Superior — captures deep intronic and regulatory variants | Moderate — limited to known exon targets |
| Accreditation | ISO 9001:2015 (Cert: INT/EGQ/2509DA/3139) & DHA-Licensed | Variable — may lack UAE-specific accreditation |
Physician Insight & Safety Protocol
A Note from Dr. PRABHAKAR REDDY (DHA License: 61713011, Clinical Pathology & Molecular Diagnostics):
"The NKX2-5 gene plays a critical role in cardiac morphogenesis and conduction system development. A pathogenic variant in this gene carries significant implications not only for the proband but for first-degree relatives who may share the same mutation. I strongly advise that every patient undergoing this test receives comprehensive pre-test and post-test genetic counselling to ensure accurate clinical correlation of the molecular findings with echocardiographic and electrocardiographic data. No single genetic result should be interpreted in isolation from the patient's full clinical picture."
⚠ MEDICATION WARNING: Do not discontinue any prescribed cardiac medication — including antiarrhythmics, beta-blockers, or anticoagulants — without prior consultation with your treating cardiologist. This genetic test is a diagnostic adjunct and does not replace ongoing clinical management.
⚠ Safety Alert — Exclusion Criteria & Emergency Red Flags
The following conditions may preclude or delay sample collection. Please disclose any to our clinical team prior to scheduling:
- Recent blood transfusion (within 4 weeks) — may cause sample admixture and compromise DNA integrity.
- Active hematologic malignancy or bone marrow transplantation within the past 3 months — donor-derived DNA may confound results.
- Current anticoagulation therapy at supratherapeutic levels — evaluate bleeding risk prior to venipuncture.
- Known allergy to latex or standard phlebotomy antiseptics — alternative materials must be arranged in advance.
🚨 Emergency Red Flags — Seek Immediate Medical Attention
This genetic test is not an emergency diagnostic procedure. If the patient experiences syncope (fainting), severe palpitations, chest pain, cyanosis (bluish discoloration of lips or skin), or sudden shortness of breath, proceed directly to the nearest emergency department. Do not delay emergency care while awaiting genetic test results. These symptoms may indicate a life-threatening arrhythmia or hemodynamic compromise requiring urgent intervention.
Patient FAQ & Clinical Guidance
Q1: What does the NKX2-5 genetic test detect, and who should consider having it done?
Snippet Answer: The NKX2-5 NGS test detects pathogenic DNA variants in the NKX2-5 gene that cause atrial septal defect and atrioventricular conduction defects, and it is recommended for anyone with a personal or family history of congenital heart disease, unexplained AV block, or familial ASD.
الإجابة المختصرة: يكشف اختبار NKX2-5 عبر تقنية NGS عن الطفرات الجينية المسببة لعيوب الحاجز الأذيني واضطرابات التوصيل الأذيني البطيني، ويُنصح به للأفراد الذين لديهم تاريخ شخصي أو عائلي لأمراض القلب الخلقية أو الإحصار الأذيني البطيني غير المبرر.
The test is particularly valuable for pediatric patients under evaluation by a pediatric cardiologist or neonatologist, adults with idiopathic AV block of unknown etiology, and asymptomatic family members of a confirmed NKX2-5 mutation carrier seeking cascade screening. A pre-test genetic counselling session — mandated under UAE Federal Decree-Law No. 41 of 2024 (Art. 87) — is required to document informed consent and construct a detailed three-generation pedigree.
Q2: How is the sample collected, and what is the total cost including home collection?
Snippet Answer: Sample collection requires a simple blood draw or one drop of blood on a DNA FTA card performed by a DHA-licensed phlebotomist during a hospital-grade home visit, with the full test priced at 2,800 AED inclusive of cold-chain transport and telephonic post-test guidance.
الإجابة المختصرة: يتم جمع العينة عبر سحب دم وريدي بسيط أو قطرة دم واحدة على بطاقة FTA للحمض النووي، ويقوم بهذا الإجراء أخصائي سحب دم مرخص من هيئة الصحة بدبي خلال زيارة منزلية. تبلغ التكلفة الإجمالية للفحص 2,800 درهم إماراتي شاملة النقل المبرد والاستشارة الوراثية الهاتفية بعد صدور النتيجة.
Three sample types are accepted: whole blood collected in an EDTA tube (preferred for highest DNA yield), extracted DNA at a minimum concentration of 50 ng/µL, or a single drop of blood applied to a DNA FTA card (ideal for neonates and infants where venipuncture may be challenging). Our VIP mobile phlebotomy service operates daily from 8:00 AM to 11:00 PM across Dubai, Abu Dhabi, Sharjah, Ajman, Umm Al Quwain, Ras Al Khaimah, and Fujairah. All samples are transported under ISO-certified cold-chain conditions to maintain DNA integrity.
Q3: Can children undergo this test, and what legal consent is required in the UAE?
Snippet Answer: Yes, children and minors can undergo NKX2-5 genetic testing in the UAE, but written informed consent from a legal guardian is mandatory under the CDS Law 2026 (Minors) and all genomic data is protected under the UAE PDPL.
الإجابة المختصرة: نعم، يمكن للأطفال والقُصّر إجراء اختبار NKX2-5 الجيني في دولة الإمارات، ولكن يجب الحصول على موافقة خطية مستنيرة من الوصي القانوني وفقاً لقانون الخدمات السريرية 2026 (القُصّر). كما تخضع جميع البيانات الجينومية للحماية بموجب قانون حماية البيانات الشخصية الإماراتي (PDPL).
Under UAE CDS Law 2026, genetic testing of minors requires dual consent: the legal guardian must sign the informed consent form, and an assent discussion must be documented for children aged 12 and above who possess sufficient maturity to understand the nature of the test. All genomic data generated is stored on encrypted, DHA-compliant servers with strict access controls in full accordance with the UAE Personal Data Protection Law (PDPL). Patients and guardians retain the right to request data deletion after clinical reporting is complete. Results are released exclusively to the referring physician and the legal guardian; no third-party access is permitted without explicit written authorization.
Regulatory Compliance & Accreditation
- ✓ Federal Decree-Law No. 41 of 2024 (Art. 87): Medical Laboratory Standards & Patient Safety — full compliance with all diagnostic accuracy and reporting mandates.
- ✓ CDS Law 2026 — Minor Consent Provisions: Dual consent and assent protocols rigorously observed for all pediatric genetic testing.
- ✓ UAE PDPL — Personal Data Protection Law: Genomic data encrypted, segregated, and protected against unauthorized access or disclosure.
- ✓ ISO 9001:2015 Certification: Certificate No. INT/EGQ/2509DA/3139 — audited and renewed for 2026 compliance cycle.
- ✓ DHA Facility License: 9834453 — issued by the Dubai Health Authority, valid and current.
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WhatsApp: +971 54 548 8731Available 8:00 AM – 11:00 PM | All Emirates | DHA-Licensed & ISO 9001:2015 Certified
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