Test Price
2,800 AEDโ Home Collection Available
๐ Results in 3โ4 weeks
MYH6 Gene Atrial Septal Defect Type 3 Genetic Test
Executive Summary & Core Metrics
- โ 99.9% Diagnostic Sensitivity โ ISO 9001:2015 (Cert: INT/EGQ/2509DA/3139) accredited NGS with Sanger confirmation for every pathogenic variant.
- โ VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection โ DHA-licensed phlebotomists collect blood or DNA at your doorstep, 8 AMโ11 PM, 7 days a week.
- โ Telephonic Post-Test Clinical Guidance โ Discuss your results with our clinical team to contextualise genetic findings.
- โ Direct Billing Verification โ WhatsApp your insurance card to +971 54 548 8731 for instant eligibility check.
Test Overview & Methodology
The MYH6 gene encodes cardiac alpha-myosin heavy chain; pathogenic variants cause autosomal dominant atrial septal defect type 3 (ASD3). This comprehensive NGS test sequences all coding exons and flanking intronic regions to identify disease-causing mutations, guiding personalised cardiac surveillance and family risk assessment.
| Feature | Our Test โ NGS + Sanger | Closest Alternative โ Targeted Sanger Only |
|---|---|---|
| Methodology | NGS (30ร mean coverage) with variant confirmation by Sanger sequencing | Sanger sequencing of limited hotspots |
| Analytical Sensitivity | >99.9% for SNVs, indels, and copy number variants (CNVs) | ~95% for common variants; may miss deep-intronic/CNV changes |
| Turnaround Time | 3โ4 weeks | 6โ8 weeks |
| Price | 2800 AED | Variable, often >3500 AED |
Physician Insight & Safety Protocols
"A positive MYH6 variant can explain a lifelong atrial septal defect, yet penetrance varies; a negative result does not exclude other genetic or environmental causes. Always integrate this result with echocardiography and cardiology follow-up. I encourage patients to use this information proactively, not fearfully."
โ Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Safety Exclusion Criteria & Emergency Red Flags
- Minors without parental consent: UAE Child Protection Law requires documented parental/guardian consent for genetic testing in individuals under 18.
- No genetic counselling: All patients must undergo a pre-test genetic counselling session to document family pedigree and understand implications.
- Acute cardiac emergency: This is an elective genetic test. If you experience sudden chest pain, palpitations, syncope, or severe shortness of breath, call 998 or go to the nearest emergency department immediately.
Medication Warning: Do not discontinue or adjust any prescribed cardiac, anticoagulant, or other medication without consulting your treating physician. Genetic results do not replace ongoing clinical management.
Patient FAQ & Clinical Guidance
1. What is the MYH6 gene and how does it relate to atrial septal defect type 3?
The MYH6 gene codes for cardiac alpha-myosin heavy chain, and inherited mutations disrupt heart septation leading to ASD3.
2. Who should consider this genetic test?
Individuals with a personal or family history of atrial septal defect, especially when diagnosed before age 40, should consider testing.
3. How is the test performed and what does the process involve?
A certified phlebotomist collects 3-5 mL of blood at your home via VIP Mobile Phlebotomy, then NGS and Sanger confirmation deliver results in 3-4 weeks.
UAE Regulatory & Data Privacy Adherence
This service strictly adheres to Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical testing safety and patient consent are governed by Federal Decree-Law No. 4 of 2016 on Medical Liability. All genetic data is handled under DHA-approved protocols.
Clinical & Logistical Metadata
| Test Name | MYH6 Gene Atrial Septal Defect Type 3 Genetic Test |
| Price (AED) | 2800 AED |
| Turnaround Time | 3โ4 weeks |
| Sample Type / Matrix | Peripheral Whole Blood (3-5 mL) or Buccal Swab (in pediatric cases) |
| Methodology Used | Next-Generation Sequencing (NGS) with Sanger confirmation |
| ICD-10-CM Code | Q21.1 |
| LOINC Code | 81319-3 |
| DHA Facility License & Laboratory Address | DHA Facility License Number: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | Corporate Lab Branding: DNA Labs UAE |
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Available in Arabic, English, Hindi & Urdu
Preparation Required
["No specific fasting required", "Do not discontinue prescribed medications"]
Medically Reviewed by Dr. Lina Osama Zaki Quteineh
All content reviewed by qualified professionals for accuracy.
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians