BRAF Mutation Analysis in UAE | 1200 AED | DHA Licensed

Executive Summary & Core Metrics

99.9% Diagnostic Sensitivity – ISO 9001:2015‑accredited laboratory processing ensures definitive BRAF mutation identification (V600E and rarer variants) for precision oncology decisions, fully aligned with DHA molecular testing standards.

Secure Courier: Archival tissue specimen retrieval (FFPE block or slides) via temperature‑controlled medical courier, available daily 8 AM‑11 PM.

Clinical Guidance: Free post‑test telephonic interpretation session with our DHA‑licensed molecular oncology advisor.

Insurance: Direct billing verification via WhatsApp at +971 54 548 8731. All major UAE insurers accepted.

Test Overview & Methodology

The BRAF Mutation Analysis detects clinically actionable somatic mutations (primarily V600E) in solid tumours. It is mandatory for initiating targeted BRAF/MEK inhibitors in melanoma, colorectal carcinoma, and certain thyroid cancers. All testing adheres to DHA precision oncology protocols, with results validated by orthogonal NGS and real‑time PCR.

Feature	Our BRAF Test	Closest Alternative (Standard Sanger)
Method	Targeted Real‑Time PCR + Next‑Generation Sequencing (NGS) confirmation	Sanger sequencing alone
Sensitivity	99.9% (LOD down to 1% VAF)	~95% (LOD ~15‑20% VAF)
Turnaround	Sample Tue 11 AM → Report Mon	10‑14 days
Reflex Testing	NGS full panel available if V600E negative (no re‑biopsy needed)	Single‑gene, requires new sample for broader profiling

Physician Insight & Safety Protocols

“A BRAF mutation result is never a stand‑alone diagnosis. It must be correlated with histopathology, staging, and clinical presentation. V600E‑positive melanoma patients often respond dramatically to dual blockade, but rare non‑V600E mutations may predict resistance. Discuss every report with a molecular tumour board before altering treatment.”

– Mr. Prabhakar Reddy Kalathoor, Specialist Diagnostic Radiology, DHA Registration ID: 61713011

Medication Advisory

Do not discontinue prescribed medication without consulting your doctor. A positive BRAF result may indicate eligibility for new targeted therapies, but stopping current treatment abruptly can cause tumour flare or serious adverse events. Always coordinate changes with your treating oncologist.

Exclusion Criteria & Emergency Red Flags

Paraffin block with <10% viable tumour cells – sample will be rejected; re‑biopsy advised.
Missing or incomplete NGS Test Requisition (Form 40) – processing halted until submitted.
Specimen frozen or shipped on dry ice for FFPE – invalid; only room‑temperature transport allowed.
Seek emergency care if you develop sudden severe pain, high fever, uncontrolled bleeding, or neurological symptoms while awaiting results.

Patient FAQ & Clinical Guidance

1. What is the purpose of a BRAF mutation test?

This test identifies acquired BRAF gene mutations (principally V600E) to guide targeted therapy selection for advanced melanoma, colorectal, and non‑small‑cell lung cancers, directly affecting survival and eligibility for kinase inhibitors.

2. How should I prepare my sample and what are the requirements?

No fasting or medication changes are needed; however, your FFPE tissue block must contain ≥10% tumour nuclei and be accompanied by a duly filled NGS Requisition (Form 40), else the sample cannot be processed.

3. When will I receive my BRAF results and who interprets them?

Samples arriving by Tuesday 11 AM are reported on the following Monday; every result is verified by a DHA‑licensed molecular pathologist and the referring oncologist receives a clinical interpretation summary.

UAE Regulatory & Data Privacy Adherence

DNA Labs UAE operates under DHA Facility License Number 1143 and adheres to Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All clinical testing and patient consent procedures are conducted in accordance with Federal Decree-Law No. 4 of 2016 on Medical Liability.

Clinical & Logistical Metadata

Test Name	BRAF Mutation Analysis
Price (AED)	1,200
Turnaround Time	6 Business Days (sample by Tuesday 11 AM, report by following Monday)
Sample Type / Matrix	Archival Tissue Specimen (FFPE block or slides)
Methodology Used	Targeted Real‑Time PCR + Next‑Generation Sequencing (NGS) confirmation
ICD-10-CM Code	Z01.818
LOINC Code	94061-7
DHA Facility License & Laboratory Address	License No. 1143 · Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE · DNA Labs UAE