Test Price
2,800 AED✅ Home Collection Available
Y Chromosome Microdeletion (AZF Region) Genetic Test – NGS Panel for Male Infertility Diagnosis in Dubai
Executive Summary & Core Metrics
Precision-Driven Genetic Analysis for Non-Obstructive Azoospermia
- Diagnostic Accuracy: 99.9% sensitivity via ISO 9001:2015-certified next-generation sequencing (NGS) covering the entire AZFa, AZFb, AZFc, and AZFd regions.
- Patient-Centric Logistics: Complimentary temperature-controlled cold-chain home phlebotomy available daily from 8 AM to 11 PM, ensuring uncompromised DNA integrity from collection to laboratory analysis.
- Clinical Interpretation: Post-test telephonic consultation with a DHA-licensed medical geneticist to explain results and guide reproductive planning.
- Insurance Billing Support: Direct verification and claims assistance via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
This next-generation sequencing (NGS) panel scans the entire AZF region on the Y chromosome for deletions known to cause non-obstructive azoospermia. The test delivers a definitive genetic diagnosis that reproductive medicine specialists, andrologists, and urologists rely on for planning sperm retrieval techniques such as microdissection testicular sperm extraction (micro-TESE).
| Feature | Our NGS Test (DNA Labs UAE) | Conventional PCR-Based Panel |
|---|---|---|
| Technology | Next-Generation Sequencing (NGS) – full AZF-a,b,c,d coverage with bioinformatics validation | Multiplex PCR with limited STS markers |
| Diagnostic Sensitivity | 99.9% (detects partial, atypical, and mosaic deletions) | ~85–90% – may miss atypical breakpoints or low-level mosaicism |
| Turnaround Time | 3–4 Weeks (comprehensive bioinformatics analysis) | 1–2 Weeks (limited marker analysis) |
Physician Insight & Safety Protocols
Lina Osama Zaki Quteineh (Consultant Medical Genetics | DHA Registration ID: 9294403) emphasizes: “A negative AZF deletion result does not exclude all genetic causes of azoospermia; results must always be correlated with semen analysis, hormonal profile, and testicular biopsy findings. This NGS test is a cornerstone in planning assisted reproduction, especially before TESE, but it requires expert genetic interpretation to avoid false reassurance and to guide appropriate clinical action.”
Advisory Note on Medications
Do not discontinue any prescribed medication – including hormonal therapies, antioxidants, or any fertility-related supplements – before this test without consulting your infertility specialist. Abrupt changes can confound the clinical evaluation and may lead to misinterpretation of the genetic results.
Safety Exclusion Criteria & Clinical Red Flags
- Exclusion Criteria: Active systemic infection, severe anemia (hemoglobin <8 g/dL), or inability to provide informed consent for genetic testing.
- Red Flags (seek immediate medical attention): Sudden testicular pain or swelling after blood draw, signs of arterial injury (cold, pale limb), or severe allergic reaction (anaphylaxis) – though these events are extremely rare with standard phlebotomy.
- Age Restriction: This test is authorized only for adult males (18 years and older). For younger individuals, Federal Decree-Law No. 4 of 2016 on Medical Liability mandates parental consent and documented clinical necessity verified by a pediatric endocrinologist.
- Female patients, individuals not diagnosed with azoospermia, and those unwilling to participate in genetic counseling must not use this panel.
Patient FAQ & Clinical Guidance
1. What exactly does the AZF NGS test detect, and how does it help my fertility?
This test identifies Y-chromosome microdeletions in the AZFa, AZFb, and AZFc regions that are directly responsible for severe azoospermia (absence of sperm in the ejaculate). The result guides your reproductive specialist in deciding whether sperm retrieval techniques such as microdissection testicular sperm extraction (micro-TESE) are likely to be successful, and it also informs genetic counseling for family planning.
2. Can I use a finger-prick or saliva sample instead of whole blood for this genetic test?
Yes, we accept one drop of blood on an FTA card, extracted DNA, or whole blood collected in an EDTA tube. Each method is validated for NGS accuracy and requires strict temperature-controlled cold-chain transport to preserve nucleic acid integrity. A trained phlebotomist will collect the sample at your home between 8 AM and 11 PM, ensuring a secure and sterile process.
3. How is my genetic data protected under UAE law?
All genomic information is secured under the Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Your data is encrypted in transit and at rest, and it is never shared with any third party without your explicit written consent. DNA Labs UAE follows rigorous data governance protocols aligned with international best practices.
UAE Regulatory & Data Privacy Adherence
Regulatory Framework: This genetic test is performed under the regulatory oversight of the Dubai Health Authority (DHA) and complies with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) for all patient genomic data. Additionally, Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields governs the secure handling of electronic health records. Clinical safety and patient consent are strictly aligned with Federal Decree-Law No. 4 of 2016 on Medical Liability.
Data Security: All genetic results are stored in encrypted repositories with role-based access controls. No raw sequencing data or interpreted reports are disclosed to employers, insurers, or family members without a separate written authorization from the patient. DNA Labs UAE maintains ISO 9001:2015 certification (Cert: INT/EGQ/2509DA/3139) and follows CAP/CLIA-equivalent quality standards for clinical genomics.
Clinical & Logistical Metadata
| Test Name | Y Chromosome Microdeletion (AZF Region) Genetic Test – NGS Panel |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks (from sample receipt at laboratory) |
| Sample Type / Matrix | Whole Blood (EDTA), FTA Card, or Extracted DNA – VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM |
| Methodology Used | Next-Generation Sequencing (NGS) – Full AZF-a, AZF-b, AZF-c, and AZF-d coverage with bioinformatics analysis |
| ICD-10-CM Code | N46.8, Z31.41, Q98.8, Z14.0 |
| LOINC Code | 94520-7 |
| DHA Facility License & Laboratory Address | Facility License: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | Corporate Lab: DNA Labs UAE |
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