Test Price
2,500 AED✅ Home Collection Available
Plasminogen Activator Inhibitor-1 (PAI-1 / SERPINE-1) 4G/5G Genotyping Test in UAE | 2500 AED | 2026 DHA Guidelines
تحليل النمط الجيني لمثبط منشط البلازمينوجين-1 (PAI-1/SERPINE-1) 4G/5G في الإمارات | 2500 درهم | معتمد من هيئة الصحة بدبي
الملخص التنفيذي
يقدم هذا التحليل تقييمًا دقيقًا لمخاطر الجلطات الدموية الوريدية والشريانية من خلال الكشف عن الطفرات الجينية لجين SERPINE-1 بتقنية PCR المتطورة، مع ضمان جودة مختبرية معتمدة من هيئة الصحة بدبي وفق معايير ISO 9001:2015، ويشمل سحب دم منزلي مبرد وخدمة استشارة طبية بعد النتيجة.
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO Accredited Processing.
- Premium Logistics: Paid Hospital-Grade Home Collection via ISO Certified Cold-Chain Home Collection & VIP Mobile Phlebotomy.
- Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731
Overview
This genotyping test identifies the 4G/5G polymorphism in the SERPINE-1 (PAI-1) gene, a key regulator of fibrinolysis, to assess inherited susceptibility to venous and arterial thromboembolic events. يكشف هذا الاختبار عن تعدد الأشكال 4G/5G لتقييم الاستعداد الوراثي للجلطات.
| Feature | Our Test (DHA Certified) | Closest Alternative |
|---|---|---|
| Precision | Allele‑specific PCR with 99.9% sensitivity; dual‑confirmation sequencing for ambiguous calls | Conventional PCR; may require repeat testing for unclear genotypes |
| Methodology | PCR amplification followed by capillary electrophoresis / Sanger validation (LC‑MS/MS‑grade reagent surveillance) | Basic PCR with gel electrophoresis; limited quality control |
| Speed | 9‑day TAT (sample receipt Tue by 11 am) | 12–15 working days |
| Compliance | ISO 9001:2015, UAE PDPL, DHA‑MOHAP standards | Variable accreditation |
Physician Insight & Safety Protocol
“Dear Patient, the PAI‑1 4G/5G genotype offers valuable insight into your thrombotic risk profile. However, a 4G/4G result is a risk marker, not a diagnosis; it must be interpreted alongside your full clinical history, family background, and other thrombophilia markers. I strongly recommend a comprehensive consultation with your hematologist or cardiologist before making any treatment decisions. — Dr. Prabhakar Reddy, Hematologist (DHA License: 61713011)”
🛑 Exclusion Criteria & Emergency Red Flags
- Exclusion Criteria: Severe anemia (Hb < 7 g/dL), acute skin infection or hematoma at venipuncture site, known allergy to EDTA, inability to understand informed consent, use of high‑dose anticoagulants that contraindicate blood draw without physician clearance.
- ER Red Flags: If after sample collection you experience excessive bleeding, expanding hematoma, fainting, or signs of infection (redness, warmth, pus), seek immediate medical attention.
📋 Pre‑Test Logistics
Sample: 4 mL (minimum 2 mL) whole blood in 1 Lavender top (EDTA) tube. Ship refrigerated. DO NOT FREEZE.
Mandatory Form: Duly filled Genomics Clinical Information Requisition Form (Form 20) must accompany the specimen.
Home Collection: Available daily 8 AM – 11 PM with ISO‑certified cold‑chain transport. WhatsApp +971 54 548 8731 to schedule.
Clinical Support: Post‑result tele‑guidance included. Direct billing verification via WhatsApp.
UAE Regulatory & Legal Adherence
- Compliant with Federal Decree‑Law No. 41 of 2024 on Medical Liability (Art. 87) – all results are reported under physician supervision.
- Adheres to CDS Law 2026 for minors; parental consent and genetic counselling are mandatory for patients under 18 years.
- Full compliance with UAE PDPL (Personal Data Protection Law) – genomic data is encrypted, anonymized, and stored securely.
- Laboratory holds ISO 9001:2015 certification (Cert: INT/EGQ/2509DA/3139) and DHA‑MOHAP accreditation.
Patient FAQ & Clinical Guidance
1. What is PAI‑1 4G/5G genotyping, and why is it requested?
This test detects the 4G/5G polymorphism in the SERPINE‑1 gene to assess inherited thrombophilia risk. يكشف هذا التحليل عن تعدد الأشكال 4G/5G في جين SERPINE‑1 لتقييم خطر الجلطات الوراثية. A 4G/4G genotype is associated with higher PAI‑1 levels, impairing clot breakdown and increasing the likelihood of venous thromboembolism, myocardial infarction, or recurrent pregnancy loss. Your doctor uses this information alongside clinical history and other tests to personalize prevention strategies.
2. How is the sample collected, and what must I do before the?
A 4 mL whole blood sample in a Lavender top EDTA tube is collected and shipped refrigerated without freezing. تُسحب عينة دم كامل بحجم 4 مل في أنبوب يحتوي على EDTA أرجواني، وتُنقل مبردة دون تجميد. You must complete the Genomics Clinical Information Requisition Form (Form 20) accurately. Do not freeze the tube; our phlebotomist handles cold‑chain logistics. Home collection is available from 8 AM to 11 PM; please remain hydrated and inform the collector of any anticoagulant medications.
3. When can I expect results, and what do the possible genotypes mean?
Results are reported in 9 days, indicating 4G/4G, 4G/5G, or 5G/5G genotypes with risk interpretation. تصدر النتائج خلال 9 أيام، وتوضح النمط الجيني (4G/4G أو 4G/5G أو 5G/5G) مع تفسير المخاطر. The report includes the specific genotype, its thrombotic risk level, and clinical correlation. 4G/4G carriers have a higher lifetime risk, while 5G/5G is considered protective. A genetic counsellor or your specialist will explain the implications and potential need for further thrombophilia workup or prophylactic measures.
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