Test Price
2,500 AED✅ Home Collection Available
Plasminogen Activator Inhibitor-1 (PAI-1 / SERPINE-1) 4G/5G Genotyping Test in UAE | 2500 AED | DHA Licensed
Executive Summary & Core Metrics
Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO Accredited Processing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM).
- Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
This genotyping test identifies the 4G/5G polymorphism in the SERPINE-1 (PAI-1) gene, a key regulator of fibrinolysis, to assess inherited susceptibility to venous and arterial thromboembolic events. The result provides insight into thrombotic risk profile, guiding personalized prevention and treatment strategies.
| Feature | Our Test (DHA Certified) | Closest Alternative |
|---|---|---|
| Precision | Allele‑specific PCR with 99.9% sensitivity; dual‑confirmation sequencing for ambiguous calls | Conventional PCR; may require repeat testing for unclear genotypes |
| Methodology | PCR amplification followed by capillary electrophoresis / Sanger validation (LC‑MS/MS‑grade reagent surveillance) | Basic PCR with gel electrophoresis; limited quality control |
| Speed | 9‑day TAT (sample receipt Tue by 11 am) | 12–15 working days |
| Compliance | ISO 9001:2015, UAE PDPL, DHA‑MOHAP standards | Variable accreditation |
Physician Insight & Safety Protocols
“Dear Patient, the PAI-1 4G/5G genotype provides valuable insight into your thrombotic risk profile. However, a 4G/4G result is a risk marker, not a diagnosis; it must be interpreted alongside your full clinical history, family background, and other thrombophilia markers. I strongly recommend a comprehensive consultation with your hematologist or cardiologist before making any treatment decisions.” — Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Important Safety Advisory
Do not discontinue prescribed anticoagulant or antiplatelet medication without consulting your doctor. Stopping therapy abruptly may cause life-threatening thromboembolic events.
Exclusion Criteria & Emergency Red Flags
- Exclusion Criteria: Severe anemia (Hb < 7 g/dL), acute skin infection or hematoma at venipuncture site, known allergy to EDTA, inability to understand informed consent, use of high‑dose anticoagulants that contraindicate blood draw without physician clearance.
- ER Red Flags: If after sample collection you experience excessive bleeding, expanding hematoma, fainting, or signs of infection (redness, warmth, pus), seek immediate medical attention.
Patient FAQ & Clinical Guidance
1. What is PAI-1 4G/5G genotyping, and why is it requested?
This test detects the 4G/5G polymorphism in the SERPINE-1 gene to assess inherited thrombophilia risk. A 4G/4G genotype is associated with higher PAI-1 levels, impairing clot breakdown and increasing the likelihood of venous thromboembolism, myocardial infarction, or recurrent pregnancy loss. Your doctor uses this information alongside clinical history and other tests to personalize prevention strategies.
2. How is the sample collected, and what must I do before the test?
A 4 mL whole blood sample is collected in a Lavender top EDTA tube and shipped refrigerated without freezing. You must complete the Genomics Clinical Information Requisition Form (Form 20) accurately. Do not freeze the tube; our phlebotomist handles cold‑chain logistics. Home collection is available from 8 AM to 11 PM; please remain hydrated and inform the collector of any anticoagulant medications.
3. When can I expect results, and what do the possible genotypes mean?
Results are reported in 9 days, indicating 4G/4G, 4G/5G, or 5G/5G genotypes with risk interpretation. The report includes the specific genotype, its thrombotic risk level, and clinical correlation. 4G/4G carriers have a higher lifetime risk, while 5G/5G is considered protective. A genetic counsellor or your specialist will explain the implications and potential need for further thrombophilia workup or prophylactic measures.
UAE Regulatory & Data Privacy Adherence
Regulatory Compliance
- Compliant with Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) – genomic data is encrypted, anonymized, and stored securely.
- Adheres to Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields for data security in healthcare.
- Clinical testing safety and patient consent follow Federal Decree‑Law No. 4 of 2016 on Medical Liability.
- Laboratory holds ISO 9001:2015 certification and DHA‑MOHAP accreditation.
Clinical & Logistical Metadata
| Test Name | PAI-1 (SERPINE-1) 4G/5G Genotyping |
| Price (AED) | 2,500 |
| Turnaround Time | 9 days |
| Sample Type / Matrix | Whole blood (EDTA) – VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection |
| Methodology Used | Allele‑specific PCR with capillary electrophoresis / Sanger validation |
| ICD-10-CM Code | Z15.09, D68.59 |
| LOINC Code | 49927-1 |
| DHA Facility License & Laboratory Address | DHA Facility License Number: 1143 Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE DNA Labs UAE |
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ISMS 27001:2022
ISO Accredited
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All reports reviewed by DHA-Certified physicians