PROC Gene Protein C Deficiency (AD) Genetic Test in UAE | 2800 AED | DHA Licensed

Executive Summary & Core Metrics

Core Metrics

•Diagnostic Sensitivity: 99.9% via ISO 9001:2015 accredited laboratory using Next-Generation Sequencing (NGS).
•VIP Mobile Phlebotomy: Temperature-controlled cold-chain home collection available daily 8 AM – 11 PM.
•Post-Test Consultation: Telephone interpretation with a medical geneticist following result delivery.
•Insurance & Payment: Direct coverage verification via WhatsApp +971 54 548 8731.

Test Overview & Methodology

This advanced next-generation sequencing (NGS) assay targets the PROC gene to detect autosomal dominant Protein C deficiency, a major inherited thrombophilia. The test provides a definitive molecular diagnosis, guiding lifelong thromboprophylaxis and family screening.

Feature	Our PROC NGS Test	Closest Alternative (Functional Assay)
Precision	Full gene sequencing & copy number analysis – detection of point mutations, indels, CNVs	Plasma Protein C activity level – influenced by acute events, warfarin, liver disease
Methodology	NGS (Next Generation Sequencing) on Illumina® platform, depth ≥300×	Chromogenic or clotting‑based functional assay
Turnaround	3–4 Weeks	1–3 Days
Clinical Utility	Confirms hereditary status, guides family screening, prognostic for VTE recurrence	Screening only; may miss type II (qualitative) deficiencies

Physician Insight & Safety Protocols

“As a Consultant Medical Genetics, I emphasize that a positive PROC variant must be correlated with personal and family thrombosis history. This test empowers patients to make informed decisions about pregnancy, surgery, and long‑term anticoagulation, always under specialist guidance. Never alter therapy based solely on a genetic result.”

— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403

Important Medication Advisory

Do not discontinue prescribed anticoagulants or antiplatelets before this test without direct consultation with your treating physician. Genetic results do not replace clinical risk assessment.

Exclusion Criteria & Safety Net

Acute Thrombotic Event: Sampling during active VTE or within 4 weeks of a major thrombotic episode may alter DNA quality; consider deferring.
Recent Blood Transfusion: Transfused whole blood may interfere with DNA extraction; wait 4 weeks post‑transfusion.
Minors (UAE Medical Liability Law): Individuals under 18 years require notarised parental consent and mandatory genetic counselling prior to sample collection per Federal Decree-Law No. 4 of 2016.
Pregnancy/Lactation: Not a contraindication, but genetic counselling must include implications for newborn.
Incapacity for Informed Consent: Legal guardians must provide documentation per UAE PDPL.

🚨 Seek Emergency Care If You Experience:

Sudden breathlessness, sharp chest pain, unilateral leg swelling/redness, severe headache, or visual changes – these may indicate acute venous thromboembolism or cerebral vein thrombosis.

Patient FAQ & Clinical Guidance

1. What does the PROC genetic test detect?

This NGS-based assay reads the entire PROC gene sequence to identify pathogenic variants, deletions, or duplications that cause hereditary Protein C deficiency, significantly elevating your lifetime risk of venous thromboembolism.

2. How will my blood sample be collected?

A certified phlebotomist will collect a standard blood sample at your home or a clinic via our VIP Mobile Phlebotomy service. No fasting is required, but inform your doctor about all medications you are taking.

3. What does a positive result mean for my family and future health?

A positive result confirms a hereditary thrombophilia, enabling targeted prevention during pregnancy, surgery, and travel. Cascade testing of first-degree relatives is strongly recommended to identify others at risk.

UAE Regulatory & Data Privacy Adherence

Regulatory Compliance & Data Protection

This testing service operates under the regulatory framework of the Dubai Healthcare City Authority and complies with the following UAE federal laws:

Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) – ensuring the confidentiality and security of your genetic data.
Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields – governing electronic health data management.
Federal Decree-Law No. 4 of 2016 on Medical Liability – guiding patient consent and clinical responsibility.

DHA Facility License Number: 1143

Clinical & Logistical Metadata

Test Name	PROC Gene Protein C Deficiency (AD) Genetic Test
Price (AED)	2,800 AED
Turnaround Time	3–4 Weeks
Sample Type / Matrix	Whole blood (peripheral) – VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available
Methodology Used	Next-Generation Sequencing (NGS) on Illumina® platform, depth ≥300×
ICD-10-CM Code	D68.59 (Primary thrombophilia, Protein C deficiency), Z15.89, Z13.79
LOINC Code	48769-0
DHA Facility License & Address	DNA Labs UAE – Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE. License No. 1143