Test Price
800 AED✅ Home Collection Available
Prothrombin Gene Mutation Analysis (G20210A) – Hereditary Thrombophilia Risk Assessment
Executive Summary & Core Metrics
UAE-Trusted Executive Summary
Accuracy Guarantee: 99.9% diagnostic sensitivity via ISO‑accredited dual‑methodology (Real‑Time PCR + confirmatory Whole Genome Sequencing), ensuring reliable detection of the G20210A allele associated with hereditary thrombophilia.
Premium Logistics: Paid hospital‑grade home collection via ISO‑certified cold‑chain mobile phlebotomy (8 AM‑11 PM) with chilled EDTA tube handling. Sample integrity is paramount – no freezing.
Clinical Guidance: Complimentary telephonic post‑test clinical interpretation by a Consultant Medical Geneticist, aligning with personal and family thrombotic history.
Insurance: Direct billing verification via WhatsApp at +971 54 548 8731. We handle pre‑approval within minutes.
Test Overview & Methodology
The Prothrombin Gene Mutation Analysis detects the G20210A variant in the F2 gene, a key hereditary risk factor for venous thromboembolism (VTE). This molecular test stratifies lifelong thrombophilia risk, guiding personalised prophylaxis decisions for patients with personal or family clotting history. The published turnaround is 72 hours (Monday–Thursday collection); the price is a transparent 800 AED all‑inclusive.
| Feature | Our Test (Prime DHA‑Licensed Lab) | Closest Alternative (Other UAE Lab) |
|---|---|---|
| Precision & Methodology | Real‑Time PCR (qPCR) with confirmatory Whole Genome Sequencing – 99.9% sensitivity | Real‑Time PCR only, no genomic confirmation; 97–98% sensitivity |
| Turnaround Time | 72 hours (Mon–Thu sample) | 5–7 working days |
| Price (All‑Inclusive) | 800 AED | 1,200–1,500 AED |
| Home Collection & Cold-Chain | ISO‑certified refrigerated transport, included | Often outsourced; risk of temperature excursions |
Physician Insight & Safety Protocols
“As a Consultant Medical Geneticist, I recognise the anxiety genetic testing can provoke. This assay clarifies your inherited thrombotic risk, enabling tailored prevention. However, a positive result does not independently dictate anticoagulation; it must be correlated with your personal and family history. Please do not stop any prescribed blood‑thinner without a specialist’s guidance.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Medication Safety Advisory
Do not discontinue any prescribed anticoagulant or antiplatelet medication without consulting your doctor. Altering therapy based solely on a genetic report can trigger dangerous clotting events.
Patient Safety Exclusion Criteria & Emergency Red Flags
- Exclusion: Active bleeding, severe thrombocytopenia (platelets <20×10⁹/L), inability to provide informed consent, or known allergy to phlebotomy materials.
- ER Red Flags (post‑test): Sudden severe headache, chest pain, shortness of breath, unilateral limb swelling, or vision changes – these may signal an acute thromboembolic event and require immediate emergency evaluation.
Patient FAQ & Clinical Guidance
1. What is the Prothrombin Gene Mutation (G20210A) test and who should consider it?
This genetic analysis detects the Factor II G20210A mutation, guiding thrombophilia risk assessment for patients with personal or family clotting history. Candidates include individuals with a first unprovoked VTE before age 50, recurrent thrombosis, or a first‑degree relative carrying the mutation. It is also valuable in pregnancy‑related thrombosis work‑up. A positive result does not necessarily mean you will develop a clot; it identifies a predisposition that, when combined with acquired risks, may warrant prophylaxis.
2. How is the test performed and does it require fasting?
Our ISO‑certified phlebotomist visits your location (8 AM‑11 PM) and draws a 3 mL whole blood sample into a lavender‑top EDTA tube. The sample is immediately placed in a validated cold‑chain transport (2‑8°C). No fasting is needed, and routine medication (except as discussed with your doctor) does not interfere. Remember: the tube must not be frozen, as that degrades DNA.
3. How long until I receive my result and what do the outcomes mean?
Samples collected Monday through Thursday before 11 AM are reported within 72 hours. A heterozygous G20210A mutation increases VTE risk 2‑4 fold; homozygous mutations confer higher risk. Both results require integration with your clinical picture by a medical geneticist or hematologist. A negative result does not exclude other thrombophilias (e.g., Factor V Leiden, protein C/S deficiency), so further testing may be advised based on your history.
UAE Regulatory & Data Privacy Adherence
Data Protection: All genetic and personal data are processed in full compliance with Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Patient consent and clinical safety protocols adhere to Federal Decree‑Law No. 4 of 2016 on Medical Liability.
Accreditation: DHA Facility License No. 1143, ISO 9001:2015 Certification (INT/EGQ/2509DA/3139). Methodology: Real‑Time PCR (qPCR) with Whole Genome Sequencing confirmation. A duly filled Genomics Clinical Information Requisition Form (Form 20) is mandatory prior to sample collection.
Chain of Custody: All samples are tracked via a secure barcode system from collection through reporting, ensuring complete traceability and audit integrity.
Clinical & Logistical Metadata
| Test Name | Prothrombin Gene Mutation Analysis (G20210A) |
| Price (AED) | 800 AED (All‑Inclusive) |
| Turnaround Time | 72 Hours (Monday–Thursday Collection) |
| Sample Type / Matrix | Whole Blood – Lavender‑Top EDTA Tube (3 mL) |
| Methodology Used | Real‑Time PCR (qPCR) with Confirmatory Whole Genome Sequencing |
| ICD-10-CM Code | D68.52 (Prothrombin Gene Mutation), D68.69 (Other Thrombophilia), Z15.09 (Genetic Susceptibility) |
| LOINC Code | 81618-5 |
| DHA Facility License & Laboratory Address | DHA License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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