Test Price
800 AED✅ Home Collection Available
Thalassemia Alpha Mutation Analysis in UAE | 800 AED | DHA Licensed & PDPL Compliant
Executive Summary & Core Metrics
This advanced molecular assay confirms alpha thalassemia carrier status and disease subtypes with over 99.9% sensitivity, using gold-standard PCR and MLPA technology. Our logistics offer temperature-controlled home collection by certified phlebotomists from 8 AM to 11 PM daily, ensuring specimen integrity. A complimentary telephonic consultation with a genetic counselor is provided post-report.
Test Overview & Methodology
This molecular assay detects deletions and point mutations in the HBA1 and HBA2 genes using PCR and MLPA, providing definitive diagnosis of alpha thalassemia syndromes, silent carrier status, and hemoglobin H disease. The multiplex ligation-dependent probe amplification (MLPA) technique ensures high sensitivity even when standard electrophoresis fails.
| Feature | Our Test (Alpha Mutation Analysis) | Closest Alternative (Hb Electrophoresis/HPLC) |
|---|---|---|
| Precision | Gene-level deletion/duplication resolution | Protein-level only; misses silent carriers |
| Methodology | MLPA + PCR (Multiplex Ligation-dependent Probe Amplification) | Hemoglobin fraction quantification |
| Speed (TAT) | Sample Mon by 9 am → Report Fri | Often next day but limited sensitivity |
| Clinical Utility | Confirms alpha-thal trait, HbH disease, genetic counseling | Screen only; false negatives in alpha thal |
Physician Insight & Safety Protocols
Lina Osama Zaki Quteineh, Consultant Medical Genetics (DHA Registration ID: 9294403): “While this assay provides definitive genetic evidence of alpha globin mutations, clinical correlation, complete blood count, and family studies remain essential for comprehensive interpretation. I encourage you to discuss results with a hematologist or genetic counsellor to understand inheritance risks and disease management. Please remember that this test supports—but does not replace—your ongoing clinical care and monitoring.”
Clinical Advisory
Do not discontinue prescribed medication without consulting your doctor. Any adjustment of iron chelation or transfusion therapy should be supervised by your treating physician.
Exclusion Criteria & ER Red Flags
- Exclusion: Patient refusal, incomplete Genomics Clinical Information Requisition Form (Form 20), hemodynamic instability precluding safe venipuncture, severe coagulopathy without physician clearance.
- ER Red Flags: If you experience sudden severe anemia symptoms – fainting, chest pain, difficulty breathing, or profound pallor – seek emergency care immediately and do not wait for results.
- Home collection is not performed if the patient has active bleeding or is in an acute medical crisis; the team will advise hospital referral.
Patient FAQ & Clinical Guidance
1. What does the Alpha Thalassemia Mutation Analysis detect?
Alpha Thalassemia Mutation Analysis detects deletions and point mutations in the HBA1/HBA2 genes, confirming diagnosis and carrier status for informed decisions. It identifies common deletions (‑‑SEA, ‑α3.7, ‑α4.2) and point mutations, distinguishing silent carriers, alpha thalassemia trait, hemoglobin H disease, and hydrops fetalis using multiplex ligation-dependent probe amplification (MLPA) for high sensitivity.
2. How should I prepare for the blood collection?
Complete the Genomics Clinical Information Form and give blood; no dietary or medication changes required. You only need to fill the mandatory Genomics Clinical Information Requisition Form (Form 20) with accurate personal and medical history. A minimum of 2 mL whole blood in a lavender-top EDTA tube is collected, ideally 4 mL. No fasting or stopping medications is necessary unless your doctor specifies otherwise. The form is available at the time of home collection or can be sent electronically.
3. When will I receive my results, and what support is provided?
The report is delivered on Friday if sample is collected Monday by 9 AM; telephonic counseling available. After collection by 9 am Monday (cold-chain maintained), the molecular analysis takes 5 working days; the final report is released on Friday. A dedicated clinical team provides a complimentary telephonic consultation to explain the findings in plain language. You may also schedule an in-depth session with our genetic counselor. Results include clear diagnostic interpretation and recommended next steps.
UAE Regulatory & Data Privacy Adherence
Regulatory Adherence
This facility operates under DHA License No. 1143 and adheres to Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 concerning the Use of Information and Communication Technology in Health Fields. Clinical safety and patient consent follow Federal Decree-Law No. 4 of 2016 on Medical Liability. ISO 9001:2015 Certified (INT/EGQ/2509DA/3139). Home collection logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily 8 AM–11 PM.
Clinical & Logistical Metadata
| Test Name | Thalassemia Alpha Mutation Analysis |
| Price (AED) | 800 AED |
| Turnaround Time | 5 working days (Sample Mon by 9 AM → Report Fri) |
| Sample Type / Matrix | Whole Blood (EDTA tube) |
| Methodology Used | PCR & MLPA (Multiplex Ligation-dependent Probe Amplification) |
| ICD-10-CM Code | D56.0 |
| LOINC Code | 49685-6 |
| DHA Facility License & Laboratory Address | DHA License: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE – DNA Labs UAE |
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Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
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All reports reviewed by DHA-Certified physicians