Test Price
2,400 AED✅ Home Collection Available
Beta Thalassemia HBB Full Gene Trio Analysis (Couple & Prenatal) – 2400 AED
Executive Summary & Core Metrics
- Price: 2,400 AED
- Turnaround Time: 8–10 working days
- Sample Type: Peripheral blood (parents), Amniotic fluid, Chorionic villi, or Cord blood (fetus)
- Methodology: Sanger sequencing (Gold Standard) – ISO 9001:2015
- Diagnostic Accuracy: >99% sensitive for causative mutations
Clinical Utility
Preconception risk stratification, prenatal decision‑making, preimplantation genetic testing planning. Results require correlation with CBC, electrophoresis, and family history.
Insurance Billing
WhatsApp your insurance card to +971545488731 for verification and pre‑authorization.
Test Overview & Methodology
The Beta Thalassemia HBB Full Gene Trio Analysis simultaneously sequences the entire HBB gene (coding and regulatory regions) in both parents and the fetal sample using gold‑standard Sanger sequencing. It identifies all known pathogenic mutations causing beta‑thalassemia, including rare UAE‑specific variants, providing a complete genetic risk profile for informed reproductive decisions.
| Feature | Our Trio HBB Full Gene Analysis | Standard Hemoglobin Electrophoresis |
|---|---|---|
| Diagnostic Target | Entire HBB gene (coding + regulatory regions) in both parents and fetus | Quantification of hemoglobin A, A2, F – no DNA analysis |
| Detection Rate | >99% of causative mutations, including rare UAE‑specific variants | ~80% carrier detection; misses silent mutations & alpha‑thal interactions |
| Methodology | Sanger Sequencing (Gold Standard), ISO 9001:2015 compliant | Capillary electrophoresis (HPLC) |
| Turnaround Time | 8–10 days | 2–3 days |
| Clinical Utility | Preconception risk stratification, prenatal decision‑making, preimplantation genetic testing planning | Initial screening only; needs reflex DNA test |
Physician Insight & Safety Protocols
“As a DHA‑licensed Consultant Medical Genetics, I emphasize that no single laboratory result should be interpreted in isolation. The Beta Thalassemia HBB Trio Analysis provides crucial data, but it must be correlated with complete blood count, hemoglobin electrophoresis, and clinical family history. A non‑pathogenic variant does not wholly exclude the possibility of a fetal hemoglobinopathy, and genetic counselling is mandatory before any reproductive decision.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Medication Safety Advisory
Do not discontinue prescribed medication (iron chelators, folic acid, etc.) without explicit consultation with your treating physician. Genetic test results must not override existing treatment plans. Always consult your specialist before making changes.
Exclusion Criteria & Emergency Red Flags
- Severe maternal anemia (Hb <7 g/dL) or hemodynamic instability – emergency care first.
- Active infection at proposed puncture site (amniocentesis/CVS) – postpone collection.
- Unexplained vaginal bleeding or ruptured membranes in pregnancy – immediate ER visit.
- Fetal distress signs: decreased movement, abnormal Doppler – refer to fetal medicine unit.
- Known coagulopathy or anticoagulant therapy without clearance – high risk procedure.
Patient FAQ & Clinical Guidance
1. What is the Beta Thalassemia HBB Full Gene Trio Analysis?
This comprehensive genetic test sequences the entire HBB gene in both parents and the fetus to detect any pathogenic mutation responsible for beta‑thalassemia. It simultaneously screens the HBB coding and splice‑site regions in maternal, paternal, and fetal DNA, revealing homozygous, compound heterozygous, or trait status with near‑complete sensitivity.
2. Who should consider this trio prenatal in the UAE?
Couples with a family history of beta‑thalassemia, consanguineous marriages, or abnormal hemoglobin electrophoresis should pursue this trio analysis for definitive risk assessment. It is recommended for all at‑risk couples early in pregnancy (before 12 weeks) to allow time for genetic counselling and informed options under UAE law.
3. How is the sample collected and is it safe for the pregnancy?
The fetal sample (amniotic fluid or chorionic villi) is collected under ultrasound guidance by a DHA‑licensed obstetrician in a hospital setting. The risk of procedure‑related miscarriage is <0.1%. Parental blood samples can be drawn via standard venipuncture. Hospital extraction only – mobile home collection is disabled for safety.
4. What do the results mean for my pregnancy?
Results indicate whether the fetus is affected (homozygous or compound heterozygous), a carrier (heterozygous), or unaffected. Genetic counselling is mandatory to understand implications for the current pregnancy and future family planning. UAE law permits termination for severe fetal anomalies within specified gestational limits.
5. How long does it take to get results?
The turnaround time is 8–10 working days from sample receipt. Results are delivered electronically and followed by a confidential telephonic consultation with a clinical geneticist.
UAE Regulatory & Data Privacy Adherence
Regulatory Compliance
- Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL)
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields
- Federal Decree-Law No. 4 of 2016 on Medical Liability
- ISO 9001:2015 Certified – Cert. No: INT/EGQ/2509DA/3139
- DHA Facility License: 1143
- Laboratory Address: Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE
All patient data is encrypted, stored within the UAE, and processed in compliance with local data protection laws. Genetic results are shared only with the treating physician and patient upon consent.
Clinical & Logistical Metadata
| Test Name | Beta Thalassemia HBB Full Gene Trio Analysis (Couple & Prenatal) |
| Price (AED) | 2,400 |
| Turnaround Time | 8–10 working days |
| Sample Type / Matrix | Peripheral blood (parents), Amniotic fluid, Chorionic villi, or Cord blood (fetus) – Hospital extraction only |
| Methodology Used | Sanger Sequencing (Gold Standard), ISO 9001:2015 |
| ICD-10-CM Code | D56.1 (Beta thalassemia), D56.3 (Thalassemia trait), Z14.8 (Genetic susceptibility to other disease) |
| LOINC Code | 55233-1 (HBB gene mutations found) |
| DHA Facility License & Laboratory Address Invariants | License: 1143 | Address: Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
دعم ثنائي اللغة متاح
التحقق من التغطية التأمينية
Check Insurance Coverage Instantly
Stop the guesswork. Send a photo of your Insurance Card and Doctor's Prescription to our DHA-Certified Verification Team on WhatsApp.
توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians