Test Price
1,400 AED✅ Home Collection Available
Beta Thalassemia HBB Deletion/Duplication Analysis in UAE | 1400 AED | DHA Licensed
Executive Summary & Core Metrics
- Diagnostic Accuracy: 99.9% sensitivity via ISO 9001:2015 certified MLPA processing for large HBB deletions and duplications.
- Premium Home Collection: VIP Mobile Phlebotomy with temperature-controlled cold-chain logistics available daily 8 AM to 11 PM.
- Post-Test Guidance: Telephonic consultation with a Consultant Medical Geneticist to review results and next steps.
- Insurance Verification: Direct billing confirmation via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
This MLPA-based genetic test identifies large deletions and duplications in the HBB gene associated with beta-thalassemia, silent carrier states, and hereditary persistence of fetal hemoglobin (HPFH). It is prescribed by hematologists, clinical geneticists, and obstetricians for diagnostic confirmation, family cascade screening, and prenatal planning. The analysis detects copy number variations that standard PCR-based sequencing routinely misses, providing definitive molecular diagnosis for individuals with suspected beta-thalassemia syndromes.
| Feature | Our MLPA Test | Alternative (PCR-Sequencing) |
|---|---|---|
| Detection Range | Identifies whole-exon and whole-gene deletions/duplications undetectable by sequencing | Limited to single nucleotide variants and small insertions/deletions |
| Method | Multiplex Ligation-dependent Probe Amplification (ISO-validated) | Sanger sequencing / NGS panels |
| Turnaround Time | 7–10 Business Days | 10–14 Business Days |
Physician Insight & Safety Protocols
Lina Osama Zaki Quteineh, Consultant Medical Genetics (DHA 9294403) advises: “MLPA analysis of HBB copy number variants is indispensable for diagnosing beta-thalassemia carriers and affected individuals when point mutation screening yields negative results. Clinicians must correlate genetic findings with complete blood counts, hemoglobin electrophoresis, and iron studies before concluding a diagnosis. Never adjust or discontinue prescribed iron chelation or transfusion therapy without consulting your treating hematologist.”
Medication & Clinical Advisory
- Inform the phlebotomist if you are taking anticoagulants, antiplatelet agents, or iron chelation therapy prior to blood draw.
- Continue all prescribed medications unless explicitly directed otherwise by your specialist.
- Results from this test should be interpreted alongside a complete blood count and hemoglobin electrophoresis for accurate diagnosis.
- This molecular analysis is not a substitute for acute transfusion decision-making; always follow your attending hematologist’s emergency care plan.
Exclusion Criteria & Urgent Care Indicators
- Do not proceed with sample collection if you have an active bleeding disorder, severe coagulopathy, or localized infection at the venipuncture site.
- Notify the collection team immediately if you are on anticoagulant therapy so appropriate precautions can be taken.
- Seek emergency medical care if you experience: prolonged bleeding, expanding hematoma, fever above 38.5°C, or severe pain following sample collection.
- This test is intended for elective diagnostic evaluation only and must not delay urgent transfusion or clinical management.
Patient FAQ & Clinical Guidance
1. What is the HBB deletion/duplication test and when is it recommended?
This MLPA-based genetic analysis detects large genomic rearrangements in the beta-globin gene that are missed by standard sequencing. It is recommended for diagnosing beta-thalassemia, identifying silent carriers, confirming hereditary persistence of fetal hemoglobin, and providing prenatal diagnostic clarity for at-risk couples.
2. How is the sample collected and what is the turnaround time?
Samples are collected via standard peripheral blood draw through our VIP Mobile Phlebotomy service with temperature-controlled cold-chain logistics, available daily from 8 AM to 11 PM. Cord blood, amniotic fluid, or chorionic villus sampling require hospital-based collection. Final results are delivered within 7–10 business days from sample receipt at the laboratory.
3. Is a doctor's prescription required for this genetic test in the UAE?
A valid physician prescription is mandatory for diagnostic purposes. The prescription requirement is waived for prenatal carrier screening, pre-surgical clearance, and travel medical examinations under DHA regulatory guidelines. Our team can assist with prescription verification at the time of booking.
4. What do the results mean for my family members?
A positive result indicating a deletion or duplication in the HBB gene has implications for first-degree relatives who may be silent carriers or at risk of having affected children. Genetic counseling is strongly recommended, and our Consultant Medical Geneticist provides telephonic post-test guidance to discuss cascade screening options for your family.
UAE Regulatory & Data Privacy Adherence
DNA Labs UAE operates under strict compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All genetic data is encrypted, access-controlled, and processed exclusively within accredited UAE facilities. Clinical safety and patient consent protocols adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability. Our DHA-licensed laboratory (License No. 1143) undergoes annual audits to maintain compliance with UAE healthcare data protection standards.
Clinical & Logistical Metadata
| Test Name | Beta Thalassemia HBB Deletion/Duplication Analysis (MLPA) |
| Price (AED) | 1,400 AED |
| Turnaround Time | 7–10 Business Days |
| Sample Type / Matrix | Peripheral Whole Blood (standard); Cord Blood, Amniotic Fluid, Chorionic Villi (hospital collection required) |
| Methodology Used | Multiplex Ligation-dependent Probe Amplification (ISO 9001:2015 validated) |
| ICD-10-CM Code | D56.1 |
| LOINC Code | 21665-2 |
| DHA Facility License & Laboratory Address | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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