Test Price
2,800 AED✅ Home Collection Available
HBA1 Gene Alpha Thalassemia Genetic Test in UAE | DNA Labs UAE
Executive Summary & Core Metrics
The HBA1 Gene Alpha Thalassemia Genetic Test delivers high-precision next-generation sequencing (NGS) analysis of the entire HBA1 coding region. This single-assay replaces outdated gap-PCR screening methods by detecting point mutations, deletions, and copy-number variations with analytical sensitivity exceeding 99.9%. The test provides definitive carrier and diagnostic classification to guide reproductive planning, transfusion management, and lifelong clinical care. Results are delivered within 3 to 4 weeks with a complimentary tele-consultation for result interpretation.
Test Overview & Methodology
This comprehensive NGS assay targets the entire HBA1 gene using validated Illumina NovaSeq deep sequencing combined with a dedicated CNV caller. The methodology captures single-nucleotide variants (SNVs), small insertion-deletions (indels), and large deletion/duplication events in a single workflow. Each result undergoes orthogonal confirmation and is reviewed against haematological parameters and family pedigree data.
| Feature | DNA Labs UAE NGS Test |
|---|---|
| Precision | 99.9% analytical sensitivity for SNVs, indels, and CNVs across complete HBA1 gene |
| Method | High-depth NGS (Illumina NovaSeq) with dedicated CNV calling algorithm and orthogonal confirmation |
| Turnaround Time | 3 to 4 weeks including confirmation and clinical review |
| Sample Volume | 5 mL peripheral whole blood in EDTA tube |
Physician Insight & Safety Protocols
"I personally review every HBA1 NGS result because the distinction between silent carriers and homozygous alpha-zero deletions fundamentally alters reproductive risk estimates. This test provides the molecular certainty that families require, though results must always be interpreted alongside complete blood count, iron studies, and a detailed three-generation family pedigree. Genetic counselling before and after testing is essential for informed decision-making."
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403Advisory Guidance
Genetic test results must be interpreted alongside complete haematological indices and iron studies. Do not alter or discontinue any prescribed therapy without consulting your treating physician. A complimentary genetic counselling session is provided with every test result to explain variant classification, inheritance patterns, and implications for family members.
Safety – Exclusion Criteria & Clinical Red Flags
- Exclusion: Individuals who have received a bone marrow transplant within the last 6 months (donor DNA may confound results).
- Exclusion: Samples collected within 2 weeks of a packed red cell transfusion – wait 14 days to avoid donor leukocyte interference.
- Red Flag: If you experience sudden severe fatigue, pallor, jaundice, or splenic pain while awaiting results, proceed to the nearest emergency department immediately.
- Red Flag: A known pregnancy with an at-risk partner warrants urgent genetic counselling; contact our genetic counsellor for prompt guidance.
Patient FAQ & Clinical Guidance
1. What is the accuracy of NGS for alpha-thalassemia compared to older methods?
NGS detects more than 99.9% of known pathogenic variants across the entire HBA1 gene, including rare point mutations, small insertions-deletions, and large deletion-duplication events. Traditional gap-PCR screens are limited to common deletions and miss atypical rearrangements or novel variants entirely, often requiring a second MLPA assay for completeness.
2. Can a home collection service be used for this test and is it suitable for children?
Yes. Our DHA-approved VIP mobile phlebotomy and temperature-controlled cold-chain home collection service operates daily from 8 AM to 11 PM. Paediatric-trained staff are available for minors, and a legal guardian must provide signed consent prior to collection. All samples are transported under continuous temperature monitoring to DNA Labs UAE for processing.
3. How will I receive my result and what support is available afterwards?
You will receive a fully interpreted molecular report reviewed by a Consultant Medical Genetics specialist, followed by a complimentary 15-minute tele-consultation to explain variant classification, reproductive implications, and necessary cascade testing for at-risk relatives. A written summary suitable for sharing with your primary physician is also provided.
4. What does the test cost and is insurance coverage accepted?
The test is priced at 2800 AED. Direct verification of insurance coverage is available via WhatsApp at +971 54 548 8731. A detailed invoice and medical report suitable for insurance reimbursement submission are provided with every completed test.
UAE Regulatory & Data Privacy Adherence
All genetic testing and data handling at DNA Labs UAE comply with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) for genetic data privacy and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields for digital health information security. Clinical safety and patient consent procedures adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability. Pre-test genetic counselling is mandatory; a detailed family pedigree chart is collected and documented prior to analysis. Our laboratory holds DHA Facility License No. 1143 and operates under the corporate branding of DNA Labs UAE.
Clinical & Logistical Metadata
| Test Name | HBA1 Gene Alpha Thalassemia Genetic Test (NGS) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3 to 4 weeks |
| Sample Type / Matrix | Peripheral whole blood (5 mL in EDTA tube); VIP mobile phlebotomy and temperature-controlled cold-chain home collection available daily from 8 AM to 11 PM |
| Methodology Used | High-depth next-generation sequencing (Illumina NovaSeq) with CNV detection algorithm and orthogonal confirmation |
| ICD-10-CM Code | D56.0 (Alpha thalassemia) |
| LOINC Code | 92827-7 (HBA1/HBA2 gene mutation analysis) |
| DHA Facility License & Address | DHA Facility License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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