Test Price
2,800 AED✅ Home Collection Available
ZIC2 Gene Holoprosencephaly Type 5 Genetic Test – NGS Analysis in Dubai
Executive Summary & Core Metrics
- Diagnostic Accuracy: 99.9% analytical sensitivity via ISO 9001:2015 certified NGS processing with DRAGEN™ bioinformatic pipeline.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (daily 8 AM to 11 PM) for whole blood, DNA, or FTA card samples.
- Clinical Guidance: Complimentary telephonic post-test result interpretation by a DHA-licensed Consultant Medical Geneticist.
- Insurance & Billing: Direct billing verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
This next-generation sequencing (NGS) test analyzes the full coding region of the ZIC2 gene to detect pathogenic variants responsible for holoprosencephaly type 5, a severe congenital brain malformation. Comprehensive coverage of all exons and splice junctions replaces older single-exon Sanger methods, delivering faster, more complete results with superior diagnostic yield.
| Feature | Our Test (NGS – Illumina®) | Closest Alternative (Traditional Sanger Sequencing) |
|---|---|---|
| Precision | 99.9% analytical sensitivity, full gene coverage including deep intronic regions | ~99% sensitivity, limited to pre-selected hotspot exons |
| Method | Next Generation Sequencing with LC‑MS/MS validation and DRAGEN™ bioinformatic alignment | Sanger sequencing, single-exon analysis, manual read interpretation |
| Turnaround Time | 3–4 weeks (VIP express service available) | 4–6 weeks |
| Sample Collection | Home-based cold-chain phlebotomy 8 AM–11 PM (whole blood, DNA, FTA card) | Clinic visit only |
Physician Insight & Safety Protocols
Lina Osama Zaki Quteineh | Consultant Medical Genetics | DHA Registration ID: 9294403
“The ZIC2 NGS test provides definitive molecular confirmation for holoprosencephaly type 5, but variants of uncertain significance require segregation analysis and multidisciplinary clinical correlation. A positive finding should prompt paediatric neurology, craniofacial surgery, and endocrine evaluation. Pre-test and post-test genetic counselling is mandatory for informed decision-making.”
⚠ Clinical Advisory – Important Precautions
Patient Safety: Exclusion Criteria & Red Flags
- Testing cannot proceed on individuals unable to provide informed consent without legal guardian approval, in compliance with Federal Decree-Law No. 4 of 2016 on Medical Liability.
- Minors require parental consent and a mandatory pre-test genetic counselling session per UAE paediatric protection standards.
- Do not proceed if the blood sample is hemolyzed, clotted, or not collected in the specified DNA FTA card or EDTA tubes.
- ER Red Flags: Seizures, sudden loss of consciousness, severe dehydration – seek immediate emergency care, unrelated to test procedure.
Medication Advisory
Do not discontinue or modify any prescribed medications without consulting your treating physician. This genetic test is diagnostic only and does not replace ongoing clinical care or emergency interventions.
Patient FAQ & Clinical Guidance
1. What is the ZIC2 gene test and why is it important?
This advanced NGS test detects pathogenic mutations in the ZIC2 gene that cause holoprosencephaly type 5, a severe brain malformation disorder, with near‑perfect diagnostic sensitivity. Early molecular diagnosis enables timely surgical, endocrine, and neurodevelopmental interventions.
2. How is the sample collected, and is home service available in UAE?
A certified phlebotomist visits your home between 8 AM and 11 PM to collect a small blood sample or a single drop on an FTA card, with strict temperature-controlled cold-chain transport to our ISO-accredited laboratory in Dubai Healthcare City.
3. What do the results mean, and what follow-up is needed?
A pathogenic variant confirms the diagnosis of holoprosencephaly type 5; negative results reduce likelihood but require comprehensive clinical evaluation to rule out other genetic causes. All results are reviewed by a Consultant Medical Geneticist, and a telephonic counselling session is provided to discuss next steps.
4. Is this test covered by insurance?
We offer direct billing verification for select insurance plans. Please contact our billing team via WhatsApp at +971 54 548 8731 to check your coverage eligibility before scheduling sample collection.
UAE Regulatory & Data Privacy Adherence
- Data Protection: All genetic data is processed in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
- Clinical Safety: Patient consent and medical liability protections are governed by Federal Decree-Law No. 4 of 2016 on Medical Liability.
- Quality Certification: ISO 9001:2015 certified (Cert: INT/EGQ/2509DA/3139). DHA Facility License: 1143.
- Data Handling: All genomic sequence data is encrypted, access-controlled, and never shared with third parties without explicit patient consent.
Clinical & Logistical Metadata
| Test Name | ZIC2 Gene Holoprosencephaly Type 5 Genetic Test (NGS) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 weeks (VIP express service available) |
| Sample Type / Matrix | Whole Blood (EDTA), DNA, FTA Card |
| Methodology Used | Next Generation Sequencing (NGS) – Illumina® with DRAGEN™ bioinformatic pipeline and LC‑MS/MS validation |
| ICD-10-CM Code | Q04.2 (Holoprosencephaly) |
| LOINC Code | 21636-6 (DNA sequencing – Genetic analysis) |
| DHA Facility License & Laboratory Address | DHA Facility License Number: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE – DNA Labs UAE |
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