Test Price
2,800 AED✅ Home Collection Available
TANC2 Gene NGS Test for Brain Disorders in UAE | 2,800 AED | DHA-Licensed Facility 1143
Executive Summary & Core Metrics
Clinical Summary: The TANC2 Gene NGS Test detects pathogenic variants in the TANC2 gene associated with neurodevelopmental disorders including brain malformations, intellectual disability, and autism spectrum traits. This molecular diagnostic test utilizes next‑generation sequencing to achieve 99.9% analytical sensitivity, enabling precise diagnosis, genetic counseling, and personalized management.
- Accuracy: 99.9% diagnostic sensitivity via ISO‑accredited processing (ISO 9001:2015).
- Logistics: VIP mobile phlebotomy and temperature‑controlled cold‑chain home collection, available daily from 8 AM to 11 PM.
- Clinical Guidance: Post‑test telephonic consultation with a Consultant Medical Geneticist.
- Insurance: Direct billing verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The TANC2 Gene NGS Test analyzes the complete coding region, splice sites, and selected deep intronic regions of the TANC2 gene using next‑generation sequencing (NGS). Pathogenic variants are classified according to ACMG/AMP guidelines. This test is superior to traditional Sanger sequencing for detecting missense, nonsense, frameshift, splice‑site, and copy‑number variants across the entire gene.
| Feature | TANC2 NGS Test | Alternative (Sanger Sequencing) |
|---|---|---|
| Precision | Full gene coverage, CNV detection, deep intronic analysis | Limited to predefined exons, misses large deletions/duplications |
| Methodology | Next‑Generation Sequencing (NGS) with ACMG/AMP variant classification | Sanger sequencing – lower throughput, higher cost per variant |
| Turnaround Time | 3–4 weeks | 6–8 weeks (often outsourced) |
Physician Insight & Safety Protocols
“As a Consultant Medical Geneticist, I emphasize that a TANC2 variant result must be interpreted alongside full clinical context—neuroimaging, developmental history, and family pedigree are essential. This test provides molecular evidence to guide diagnosis and management; it does not replace a comprehensive clinical evaluation. Always correlate with phenotype before concluding pathogenicity.” – Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Clinical Safety & Consent Advisory
Prior to testing, informed consent must be obtained in accordance with Federal Decree‑Law No. 4 of 2016 on Medical Liability. This genetic test does not alter acute treatment plans; do not discontinue any prescribed medication without consulting your treating physician. Results require professional interpretation and should be discussed with a qualified genetic counselor.
Exclusion Criteria & Emergency Red Flags
- Inability to provide informed consent (legal guardian consent required for minors).
- Unstable clinical condition requiring immediate medical attention (e.g., acute seizures, respiratory distress).
- Recent blood transfusion (within 2 weeks) may cause chimerism in blood DNA – use buccal swab if necessary.
- ER Red Flag: If the patient experiences sudden neurological deterioration, severe headache, or loss of consciousness, seek emergency care immediately and inform the laboratory of any urgent testing requirements.
Patient FAQ & Clinical Guidance
1. What is the TANC2 gene and why is this test important?
The TANC2 gene encodes a protein that organizes synapses in the brain. Pathogenic variants are linked to neurodevelopmental disorders including intellectual disability, autism, epilepsy, and brain malformations. This test provides a precise molecular diagnosis, enabling early intervention, targeted therapies, and genetic counseling for families.
2. How is the sample collected and is a doctor’s referral required?
Sample collection is done via a simple blood draw or buccal swab. Our ISO‑certified phlebotomy team can perform the collection at home (VIP mobile phlebotomy daily from 8 AM to 11 PM) or at our facility. A valid medical referral and pre‑test genetic counseling are mandatory to ensure appropriate clinical indication and informed consent.
3. How long do results take and what does a negative result mean?
Results are available in 3–4 weeks. A negative result means no pathogenic variant was identified in the TANC2 gene, but it does not rule out other genetic disorders. Your physician may recommend additional testing (e.g., whole exome sequencing) based on the clinical presentation.
UAE Regulatory & Data Privacy Adherence
Legal Framework: This genetic test complies with the Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL), ensuring end‑to‑end encryption and restricted access to genetic data. Furthermore, it adheres to Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields, governing electronic health records and telemedicine. Patient consent and clinical safety are governed by Federal Decree‑Law No. 4 of 2016 on Medical Liability. All laboratory processes are ISO 9001:2015 certified and DHA‑licensed.
Clinical & Logistical Metadata
| Test Name | TANC2 Gene NGS Test for Brain Disorders |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 weeks |
| Sample Type / Matrix | Peripheral whole blood or buccal swab (VIP mobile phlebotomy & temperature‑controlled cold‑chain home collection available) |
| Methodology Used | Next‑Generation Sequencing (NGS) with ACMG/AMP variant classification |
| ICD‑10‑CM Code | Q87.8, G93.89, Z15.89 |
| LOINC Code | 95900-9 |
| DHA Facility License & Laboratory Address | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE – DNA Labs UAE |
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