Test Price
2,800 AED✅ Home Collection Available
TUBB3 Gene Cortical Dysplasia, Complex, With Other Brain Malformations Type 1 Genetic Test in UAE | 2,800 AED | DHA Licensed
Executive Summary & Core Metrics
Diagnostic Precision: 99.9% sensitivity via full-gene next-generation sequencing with comprehensive exon and splice-junction coverage.
Specimen Collection: VIP Mobile Phlebotomy and temperature-controlled cold-chain home collection available daily from 8 AM to 11 PM for peripheral whole blood draws.
Clinical Support: Post-test telephonic guidance for result interpretation by a Consultant Medical Geneticist.
Insurance Facilitation: Direct billing verification via WhatsApp +971 54 548 8731 prior to scheduling.
Test Overview & Methodology
This targeted genetic test employs next-generation sequencing (NGS) to identify pathogenic variants in the TUBB3 gene associated with complex cortical dysplasia with other brain malformations type 1 (CDCBM1). The analysis spans all coding exons and flanking splice junctions, enabling detection of both known and novel disease-causing mutations. Results are correlated with clinical phenotype to support definitive molecular diagnosis and informed family counselling.
| Feature | Our Test (NGS Full Gene) | Closest Alternative (Sanger Single-Site) |
|---|---|---|
| Precision | All exons and splice junctions – detection of known and novel variants | Targeted analysis of a single pre-specified mutation only |
| Method | Next-Generation Sequencing with high-depth coverage | Bidirectional Sanger sequencing |
| Turnaround Time | 3–4 weeks | 2–3 weeks (when mutation is known, not suitable for genome-wide search) |
Physician Insight & Safety Protocols
Families facing complex developmental brain malformations often carry a heavy diagnostic odyssey. This NGS-based test provides definitive molecular clarification, yet the result must always be interpreted within the broader clinical, radiological, and family history context. Genetic counselling before and after testing is essential to ensure informed decision-making and appropriate follow-up.
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Medication & Treatment Advisory
Do not alter or discontinue any prescribed medication without direct consultation with your treating physician. Genetic test results are one component of a comprehensive diagnostic evaluation and must never be used as the sole basis for therapeutic changes. Always involve your neurologist or geneticist in management decisions.
Contraindications & Exclusion Criteria
- Allogeneic blood transfusion within the past 2 weeks may confound DNA analysis.
- Active untreated infection or febrile illness at the time of sample collection.
- Inability to obtain informed consent from the patient or legal guardian.
Emergency Red Flags
Seek immediate medical attention if the patient experiences new-onset seizures, sudden loss of consciousness, rapid neurological deterioration, or signs of raised intracranial pressure (severe headache, vomiting, altered mental status). These symptoms may signal an acute, non-genetic emergency.
Patient FAQ & Clinical Guidance
1. What is the TUBB3 gene test used for?
It detects pathogenic TUBB3 variants that cause complex cortical dysplasia with other brain malformations type 1 (CDCBM1). The analysis covers the entire coding region of the TUBB3 gene to identify both known and novel mutations, enabling a definitive molecular diagnosis and informing prognosis, recurrence risk, and family planning.
2. How long does it take to receive results?
Results are available within 3 to 4 weeks from sample receipt in the laboratory. This timeline includes DNA extraction, library preparation, high-depth NGS sequencing, bioinformatic analysis, variant interpretation, and clinical report generation by our genetics team.
3. Is this genetic test covered by health insurance?
Coverage varies by policy and provider. Verify your benefits directly via WhatsApp at +971 54 548 8731 before scheduling. Our team can assist with pre-authorization and direct billing for most major UAE insurers.
UAE Regulatory & Data Privacy Adherence
All genetic testing, data handling, and reporting procedures at DNA Labs UAE comply with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical safety, patient consent, and medical liability practices are governed by Federal Decree-Law No. 4 of 2016 on Medical Liability. Your genetic information is encrypted, access-restricted, and used solely for diagnostic purposes with your explicit informed consent.
Clinical & Logistical Metadata
| Test Name | TUBB3 Gene Cortical Dysplasia, Complex, With Other Brain Malformations Type 1 Genetic Test (NGS Full Gene) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Peripheral Whole Blood |
| Methodology Used | Next-Generation Sequencing (NGS), Full Gene Analysis |
| ICD-10-CM Code | Q04.8 |
| LOINC Code | 81313-5 |
| DHA Facility License & Laboratory Address | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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