Test Price
2,800 AED✅ Home Collection Available
TMLHE Gene Sequencing for X-Linked Autism Susceptibility Type 6 (NGS) in UAE
Executive Summary & Core Metrics
Core Metrics
Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO Accredited Processing.
Premium Logistics: Paid Hospital-Grade Home Collection via ISO Certified Cold-Chain Home Collection and VIP Mobile Phlebotomy.
Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation.
Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The TMLHE gene sequencing test identifies X-linked autism susceptibility type 6, analyzing the TMLHE gene for pathogenic variants that increase the risk of autism spectrum disorder. This test is crucial for early diagnosis and family planning. Next-Generation Sequencing (NGS) technology enables comprehensive coverage of all coding exons and flanking intronic regions, ensuring high sensitivity for variant detection.
The methodology includes targeted enrichment, library preparation, and bioinformatic analysis aligned with ACMG/AMP guidelines for variant classification. Results are correlated with clinical findings to support accurate genetic counseling and risk assessment.
| Feature | Our Test | Closest Alternative |
|---|---|---|
| Precision | 99.9% Diagnostic Sensitivity (ISO) | Variable sensitivity |
| Method | Next-Generation Sequencing (NGS) | Sanger sequencing (limited) |
| Speed | 14–21 Working Days (3–4 Weeks) | 4–6 Weeks |
Physician Insight & Safety Protocols
The TMLHE gene sequencing test identifies pathogenic variants associated with X-linked autism susceptibility type 6. It is important to note that this test identifies genetic susceptibility, not a definitive diagnosis. Clinical correlation with developmental assessments and a thorough family history evaluation remain essential. Families should consult a pediatric neurologist and a genetic counselor for comprehensive interpretation and personalized management planning. Early intervention continues to be the cornerstone of improving outcomes in autism spectrum disorders.
— Lina Osama Zaki Quteineh, Consultant Medical Genetics (DHA Registration ID: 9294403)
Advisory Notice
⚠️ Important: Genetic test results should always be interpreted in the context of full clinical evaluation. A positive result indicates increased susceptibility and does not confirm a diagnosis of autism spectrum disorder. Always discuss results with a qualified healthcare professional.
Exclusion Criteria & ER Red Flags
- Exclusion Criteria: Individuals with a known bleeding disorder unsuitable for venipuncture; lack of informed consent from legal guardian for pediatric sampling.
- ER Red Flags: If the patient exhibits acute neurological changes such as seizures or loss of consciousness, or severe behavioral crises, seek immediate emergency care before proceeding with sample collection.
Patient FAQ & Clinical Guidance
1. What is the TMLHE gene test and why is it important for autism?
The TMLHE gene sequencing test detects pathogenic variants in the TMLHE gene associated with X-linked autism susceptibility, helping confirm genetic risk and guiding early intervention strategies. Identifying a genetic basis supports tailored developmental therapies and family planning decisions.
2. How should I prepare for the TMLHE gene sequencing test?
A genetic counseling session to draw a pedigree chart is required before sample collection. No fasting or medication changes are needed unless advised by your physician. The test requires a peripheral blood sample or saliva specimen collected in a sterile container.
3. What do the results mean and what are the next steps?
A positive result indicates an increased genetic susceptibility to autism spectrum disorder. Follow-up with a pediatric neurologist and developmental specialist is crucial for personalized management. A negative result does not eliminate the possibility of other genetic or environmental causes.
4. Is home sample collection available for this genetic test?
Yes, VIP Mobile Phlebotomy and Temperature-Controlled Cold-Chain Home Collection are available daily from 8 AM to 11 PM for standard peripheral blood draws. A trained phlebotomist will collect the sample at your residence under sterile conditions.
UAE Regulatory & Data Privacy Adherence
Regulatory Compliance Framework: This diagnostic service operates in full compliance with UAE federal health data protection and medical liability regulations.
- Data Protection: All patient data is processed and stored in accordance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL), ensuring secure handling of genetic information.
- Health Information Technology: Electronic health records and test result transmission comply with Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
- Medical Liability & Patient Consent: Clinical testing safety, informed consent, and patient rights are governed by Federal Decree-Law No. 4 of 2016 on Medical Liability.
Patients retain full rights to access, correct, and request deletion of their personal data. All genetic results are encrypted and shared only with the referring physician and the patient through secure channels.
Clinical & Logistical Metadata
| Test Name | TMLHE Gene Sequencing for X-Linked Autism Susceptibility Type 6 (NGS) |
| Price (AED) | 2,800 |
| Turnaround Time | 14–21 Working Days (3–4 Weeks) |
| Sample Type / Matrix | Peripheral Whole Blood (EDTA) or Saliva Sample |
| Methodology Used | Next-Generation Sequencing (NGS) – Full Gene Sequencing |
| ICD-10-CM Code | Z15.89 (Genetic Susceptibility to Other Disease) |
| LOINC Code | 51995-8 (Genetic analysis report) |
| DHA Facility License & Laboratory Address | DHA License: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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