Test Price
2,800 AEDโ Home Collection Available
ERCC4 Gene Xeroderma Pigmentosum Group F Genetic Test | DNA Labs UAE
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% diagnostic sensitivity via ISO 9001:2015 accredited next-generation sequencing.
- Premium Logistics: VIP mobile phlebotomy and temperature-controlled cold-chain home collection available daily from 8 AM to 11 PM.
- Clinical Guidance: Post-test telephonic consultation with genetic specialist for result interpretation and management planning.
- Insurance: Direct billing verification via WhatsApp +971 54 548 8731 prior to collection.
Test Overview & Methodology
This next-generation sequencing test analyzes the entire coding region and splice sites of the ERCC4 gene to detect pathogenic variants causing Xeroderma Pigmentosum Group F, a rare autosomal recessive disorder characterized by extreme ultraviolet sensitivity, impaired DNA repair, and a markedly elevated risk of skin cancers. The method includes deletion/duplication analysis for complete molecular characterization.
| Feature | Our NGS Test | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Precision | 99.9% sensitivity, full gene coverage | Limited to known hotspots, ~95% |
| Methodology | NGS with deletion/duplication analysis | Sanger sequencing with MLPA if required |
| Turnaround Time | 3 to 4 weeks (ISO accredited lab) | 4-6 weeks |
| Clinical Utility | Diagnostic confirmation, carrier screening & cancer surveillance guidance | Diagnostic only |
Physician Insight & Safety Protocols
"A positive ERCC4 result must be correlated with clinical findings and family history; it is not a standalone diagnosis. Early molecular confirmation enables rigorous photoprotection, regular dermatologic surveillance, and genetic counseling for at-risk relatives. As a Consultant Medical Genetics, I strongly recommend pre-test counseling to ensure informed consent and comprehensive pedigree analysis." โ Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Pre-Test Advisory
Medication Warning: Do not discontinue any prescribed medication without consulting your doctor. This genetic test does not replace current treatment plans.
Mandatory Pre-Test Requirement: A comprehensive clinical history and genetic counseling session with a detailed three-generation pedigree chart must be completed before specimen collection. Our coordination team will arrange this prior to your appointment.
Exclusion Criteria & Emergency Red Flags
- Exclusion: Patients under 18 years without legal guardian consent as per UAE Federal Law and DHA regulations.
- Exclusion: Active severe dermatitis or skin infection at venipuncture site; specimen collection deferred until resolved.
- Emergency: If you develop acute severe sunburn, blistering, or rapidly changing moles, seek immediate dermatologic evaluation.
- Emergency: New neurological symptoms (e.g., progressive ataxia) may indicate XP neurological variantโcontact your specialist promptly.
Patient FAQ & Clinical Guidance
1. What is the clinical utility of ERCC4 genetic testing for Xeroderma Pigmentosum Group F?
This test provides definitive molecular confirmation of XP-F, enabling personalized photoprotection, cancer surveillance, and familial carrier screening with 99.9% accuracy. Early diagnosis reduces morbidity and mortality through tailored management.
2. How is the sample collected and what are the preparation requirements?
A peripheral blood draw (EDTA tube) or a few drops on an FTA card collected by a DHA-licensed phlebotomist at your preferred location. No special preparation is needed, but prior genetic counseling with a complete pedigree chart is mandatory.
3. Will my health insurance cover this genetic test in the UAE?
Coverage depends on your insurance policy. Our direct billing team verifies benefits instantly via WhatsApp +971 54 548 8731 before collection, ensuring you know your out-of-pocket costs in advance.
4. How long does it take to get results?
Turnaround time is 3 to 4 weeks from sample receipt in our ISO 9001:2015 accredited laboratory. Results are delivered electronically and include a detailed clinical interpretation.
UAE Regulatory & Data Privacy Adherence
Trust & Compliance Framework
DNA Labs UAE operates under DHA Facility License No. 1143 and adheres to the Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical safety and patient consent are governed by Federal Decree-Law No. 4 of 2016 on Medical Liability. All genetic data is encrypted, stored on UAE-based servers, and never shared without explicit consent.
Clinical & Logistical Metadata
| Test Name | ERCC4 Gene (Xeroderma Pigmentosum Group F) Sequencing & Deletion/Duplication Analysis |
| Price (AED) | 2,800 |
| Turnaround Time | 3 to 4 weeks |
| Sample Type / Matrix | Peripheral whole blood (EDTA) or FTA dried blood spot |
| Methodology Used | Next-Generation Sequencing (NGS) with deletion/duplication analysis |
| ICD-10-CM Code | Q82.1 |
| LOINC Code | 21613-5 |
| DHA Facility License & Address | License No. 1143 โ Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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All reports reviewed by DHA-Certified physicians