Test Price
2,800 AED✅ Home Collection Available
CYBB Gene (Chronic Granulomatous Disease, X‑Linked) Genetic Test in UAE – 2800 AED
Executive Summary & Core Metrics
- 99.9% Diagnostic Sensitivity via ISO‑accredited NGS processing (ISO 9001:2015 Cert: INT/EGQ/2509DA/3139).
- Premium Logistics: Hospital‑grade home collection using ISO‑certified cold‑chain transport; VIP mobile phlebotomy service (8 AM–11 PM).
- Clinical Guidance: Telephonic post‑test result interpretation by a DHA‑licensed genetic counsellor included.
- Insurance Made Easy: Direct billing verification via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
A targeted Next‑Generation Sequencing (NGS) analysis that screens the entire CYBB gene for pathogenic variants responsible for X‑linked chronic granulomatous disease (CGD), a primary immunodeficiency. This test is suitable for symptomatic males, carrier females, and suspected prenatal cases. The assay utilizes Illumina® NGS with copy‑number variation analysis, providing full gene coverage with analytical sensitivity exceeding 99.9%.
| Feature | Our Test (NGS) | Closest Alternative (Sanger Sequencing Panel) |
|---|---|---|
| Precision | Full gene coverage with >99.9% analytical sensitivity | Limited to known hotspots; may miss deep intronic or novel variants |
| Methodology | Illumina® NGS with copy‑number variation analysis | Bidirectional Sanger sequencing |
| Turnaround Time | 3–4 weeks | 6–8 weeks |
| Cost (AED) | 2,800 | 4,000 – 5,500 |
Physician Insight & Safety Protocols
“A positive CYBB mutation confirms X‑linked CGD but must be interpreted alongside DHR‑123 oxidase assay and clinical phenotype. A negative result does not rule out other CGD subtypes; always correlate with functional testing and expert immunology consultation.” – Lina Osama Zaki Quteineh (Consultant Medical Genetics, DHA Registration ID: 9294403)
Medication Advisory
⚠️ MEDICATION WARNING: Do not discontinue prescribed antibiotics, antifungals, or interferon‑gamma without explicit advice from your physician. This test does not replace acute infection management.
Patient Exclusion & Red Flags
Exclusion Criteria & Red Flags
- Exclusion: Active severe infection or recent whole blood transfusion (within 2 weeks) – may compromise DNA integrity.
- Red Flag Symptoms: If you experience high fever (>39°C), respiratory distress, or signs of sepsis, seek emergency care immediately. This genetic test is not for acute diagnostic purposes.
Patient FAQ & Clinical Guidance
1. What exactly does the CYBB gene test analyze?
This sequences the entire coding region and flanking intronic boundaries of the CYBB gene to detect pathogenic variants causing X‑linked chronic granulomatous disease with highest accuracy. It uses next‑generation sequencing (NGS) to identify single nucleotide changes, small insertions/deletions, and copy‑number variants. The report classifies variants according to ACMG guidelines, providing a definitive molecular diagnosis when correlated with clinical symptoms.
2. How is the sample collected, and does it require a hospital visit?
A certified phlebotomist visits your home to collect a 2‑mL EDTA blood sample, or you can provide extracted DNA or a dried blood spot on an FTA card—no hospital visit required. We offer VIP mobile phlebotomy service across the UAE (8 AM–11 PM, 7 days a week). The sample is immediately placed in ISO‑certified cold‑chain transport and processed in our DHA‑approved laboratory.
3. What is the turnaround time for results, and how will I receive them?
Results are issued in 3 to 4 weeks through a secure encrypted PDF and explained during a telephonic clinical guidance session with a genetic counsellor. The extended timeline accommodates rigorous sequencing, bioinformatics analysis, and clinical interpretation by our DHA‑licensed team. Preliminary reports are never released; final reports include variant classification, inheritance pattern, and personalised recommendations.
4. Can this test be performed during pregnancy?
Yes, prenatal testing is available through chorionic villus sampling or amniocentesis. These procedures must be performed at an accredited hospital. A genetic counsellor will discuss the risks and benefits prior to sampling. Home collection is not applicable for prenatal specimens.
UAE Regulatory & Data Privacy Adherence
Compliance: This service fully complies with Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Patient consent and clinical safety follow Federal Decree‑Law No. 4 of 2016 on Medical Liability. All genetic data is processed under strict confidentiality and encrypted storage protocols.
Laboratory: DHA‑licensed facility (License No. 1143), ISO 9001:2015 certified (Cert: INT/EGQ/2509DA/3139).
Clinical & Logistical Metadata
| Test Name | CYBB Gene (Chronic Granulomatous Disease, X‑Linked) Genetic Test |
| Price (AED) | 2,800 |
| Turnaround Time | 3–4 weeks |
| Sample Type / Matrix | Peripheral whole blood (EDTA) – VIP Mobile Phlebotomy & Temperature‑Controlled Cold‑Chain Home Collection (Available daily from 8 AM to 11 PM). |
| Methodology Used | Next‑Generation Sequencing (Illumina®) with copy‑number variation analysis |
| ICD-10-CM Code | D71 (Chronic granulomatous disease) |
| LOINC Code | 21636-5 (Gene mutation analysis in Blood or Tissue by Molecular genetics method) |
| DHA Facility License & Address | License No. 1143 – Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE (Corporate Lab: DNA Labs UAE) |
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All reports reviewed by DHA-Certified physicians