Test Price
2,800 AED✅ Home Collection Available
CYBB Gene (Chronic Granulomatous Disease, X‑Linked) Genetic Test in UAE | 2800 AED | 2026 DHA Guidelines
تحليل جين CYBB (داء الورم الحبيبي المزمن المرتبط بالصبغي X) في الإمارات | 2800 درهم | معتمد من هيئة الصحة بدبي
Executive Summary / الخلاصة التنفيذية
- 99.9% Diagnostic Sensitivity via ISO‑accredited NGS processing (ISO 9001:2015 Cert: INT/EGQ/2509DA/3139).
- Premium Logistics: Hospital‑grade home collection using ISO‑certified cold‑chain transport; VIP mobile phlebotomy service (8 AM–11 PM).
- Clinical Guidance: Telephonic post‑test result interpretation by a DHA‑licensed genetic counsellor included.
- Insurance Made Easy: Direct billing verification via WhatsApp at +971 54 548 8731.
Test Overview
A targeted Next‑Generation Sequencing (NGS) analysis that screens the entire CYBB gene for pathogenic variants responsible for X‑linked chronic granulomatous disease (CGD), a primary immunodeficiency. This test is suitable for symptomatic males, carrier females, and suspected prenatal cases. يقوم هذا الفحص بتحليل جين CYBB الكامل باستخدام تقنية التسلسل الجيني المتقدم للكشف عن الطفرات المسببة لداء الورم الحبيبي المزمن المرتبط بالصبغي X.
| Feature | Our Test (NGS) | Closest Alternative (Sanger Sequencing Panel) |
|---|---|---|
| Precision | Full gene coverage with >99.9% analytical sensitivity | Limited to known hotspots; may miss deep intronic or novel variants |
| Methodology | Illumina® NGS with copy‑number variation analysis | Bidirectional Sanger sequencing |
| Turnaround Time | 3–4 weeks | 6–8 weeks |
| Cost (AED) | 2,800 | 4,000 – 5,500 |
Physician Insight & Safety Protocol
“A positive CYBB mutation confirms X‑linked CGD but must be interpreted alongside DHR‑123 oxidase assay and clinical phenotype. A negative result does not rule out other CGD subtypes; always correlate with functional testing and expert immunology consultation.” – Dr. Prabhakar Reddy (DHA License: 61713011)
⚠️ MEDICATION WARNING: Do not discontinue prescribed antibiotics, antifungals, or interferon‑gamma without explicit advice from your physician. This test does not replace acute infection management.
Patient Safety – Exclusion Criteria & Red Flags
- Exclusion: Active severe infection or recent whole blood transfusion (within 2 weeks) – may compromise DNA integrity.
- Red Flag Symptoms: If you experience high fever (>39°C), respiratory distress, or signs of sepsis, seek emergency care immediately. This genetic test is not for acute diagnostic purposes.
Patient FAQ & Clinical Guidance
Q: What exactly does the CYBB gene test analyze?
First‑sentence answer: This sequences the entire coding region and flanking intronic boundaries of the CYBB gene to detect pathogenic variants causing X‑linked chronic granulomatous disease with highest accuracy.
It uses next‑generation sequencing (NGS) to identify single nucleotide changes, small insertions/deletions, and copy‑number variants. The report classifies variants according to ACMG guidelines, providing a definitive molecular diagnosis when correlated with clinical symptoms.
س: ما الذي يحلله اختبار جين CYBB بالضبط؟
إجابة مقتضبة: يقوم هذا الاختبار بتسلسل منطقة التشفير الكاملة والمناطق المجاورة لداخل جين CYBB للكشف عن الطفرات المسببة لداء الورم الحبيبي المزمن المرتبط بالصبغي X بأقصى درجات الدقة.
Q: How is the sample collected, and does it require a hospital visit?
First‑sentence answer: A certified phlebotomist visits your home to collect a 2‑mL EDTA blood sample, or you can provide extracted DNA or a dried blood spot on an FTA card—no hospital visit required.
We offer VIP mobile phlebotomy service across the UAE (8 AM–11 PM, 7 days a week). The sample is immediately placed in ISO‑certified cold‑chain transport and processed in our DHA‑approved laboratory (License 9834453).
س: كيف يتم جمع العينة، وهل يتطلب ذلك زيارة المستشفى؟
إجابة مقتضبة: يزورك فني سحب دم معتمد في منزلك لجمع عينة دم 2 مل في أنبوب EDTA، أو يمكنك تقديم حمض نووي مستخلص أو بقعة دم جافة على بطاقة FTA – دون الحاجة لزيارة المستشفى.
Q: What is the turnaround time for results, and how will I receive them?
First‑sentence answer: Results are issued in 3 to 4 weeks through a secure encrypted PDF and explained during a telephonic clinical guidance session with a genetic counsellor.
The extended timeline accommodates rigorous sequencing, bioinformatics analysis, and clinical interpretation by our DHA‑licensed team. A preliminary report is never released; final reports include variant classification, inheritance pattern, and personalised recommendations.
س: ما هو الوقت المستغرق لظهور النتائج، وكيف سأستلمها؟
إجابة مقتضبة: تصدر النتائج خلال 3 إلى 4 أسابيع بصيغة PDF مشفرة، ويتم شرحها خلال جلسة استشارة هاتفية ما بعد التحليل مع مستشار جيني.
Compliance: This service complies with Federal Decree‑Law No. 41 of 2024 (Art. 87) on medical advertising, the CDS Law 2026 on minors’ health data protection, and the UAE Personal Data Protection Law (PDPL).
Laboratory: DHA‑licensed facility (License No. 9834453), ISO 9001:2015 certified (Cert: INT/EGQ/2509DA/3139).
Insurance: Direct billing verification via WhatsApp +971 54 548 8731. For home collection booking or genetic counselling, call +971 54 548 8731 (8 AM–11 PM daily).
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All reports reviewed by DHA-Certified physicians