Test Price
2,800 AEDโ Home Collection Available
ARX Gene-Associated Agenesis of Corpus Callosum with Abnormal Genitalia (XLAG) Genetic Test in UAE | AED 2,800
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Next-Generation Sequencing (Cert: INT/EGQ/2509DA/3139) for the ARX gene, covering all coding exons and splice sites.
- Premium Logistics: Paid Hospital-Grade Home Collection via ISO-Certified Cold-Chain Logistics and VIP Mobile Phlebotomy, available daily from 8 AM to 11 PM across the UAE.
- Clinical Guidance: Complimentary telephonic post-test genetic counseling to interpret ARX results in context of neuroimaging and family history.
- Insurance: Direct Billing Verification via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
This advanced Next-Generation Sequencing (NGS) test analyzes the entire coding region of the ARX gene to detect pathogenic variants linked to X-linked lissencephaly with ambiguous genitalia (XLAG) syndrome and related conditions. It provides a definitive molecular diagnosis to aid pediatricians, neurologists, and genetic counselors in treatment planning and recurrence risk assessment.
| Test Parameter | Our Test (NGS Full Gene Sequencing) | Single-Site Sanger Sequencing |
|---|---|---|
| Methodology | Next-Generation Sequencing (NGS) with high coverage (>200x) and CNV detection | Targeted Sanger sequencing of preselected exons |
| Variant Detection | All coding SNVs, indels, and intragenic copy number variants (CNVs) | Only known specific point mutations; misses novel or CNV changes |
| Turnaround Time | 3โ4 Weeks | 1โ2 Weeks |
| Clinical Utility | Definitive molecular diagnosis, family screening, and prenatal/preimplantation options | Confirmation of known familial mutation only |
Physician Insight & Safety Protocols
Lina Osama Zaki Quteineh (DHA: 9294403), Consultant Medical Genetics, notes: โThe ARX gene NGS panel provides critical insight into XLAG syndrome, a rare X-linked disorder that requires careful phenotype-genotype correlation. Even with a negative NGS result, other genetic causes such as chromosomal abnormalities or broader gene panels may need exploration. This test must always be paired with detailed neuroimaging and comprehensive family pedigree for accurate counseling. Do not discontinue any prescribed medication without consulting your physician.โ
Advisory Guidelines
- This test is indicated for individuals with clinical features of XLAG syndrome, including agenesis of corpus callosum, genital ambiguity, seizures, and severe developmental delay.
- Asymptomatic individuals with no family history of ARX-related disorders are excluded unless part of carrier testing after genetic counseling.
- Patients must provide informed consent prior to testing as per Federal Decree-Law No. 4 of 2016 on Medical Liability.
- Continue all prescribed medications unless advised otherwise by your doctor.
Exclusion Criteria
- Minors require explicit consent from a legal guardian, complying with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
- Emergency red flags: sudden seizures, respiratory distress, or severe hypotonia after blood collection require immediate emergency care.
- Results revealing high-risk pathogenic variants must be discussed urgently with a pediatric neurologist.
Patient FAQ & Clinical Guidance
1. What is the ARX gene test and why is it ordered?
The ARX gene test detects disease-causing mutations in the ARX gene to confirm a diagnosis of X-linked lissencephaly with ambiguous genitalia (XLAG) or related syndromes, enabling precise prognosis and genetic counseling.
2. How is the sample collected?
A simple venous blood draw (3โ5 mL) or a painless finger-prick blood spot on an FTA card is collected by our DHA-licensed phlebotomist at your home, with no discomfort beyond a routine blood test.
3. Can this be performed during pregnancy?
Prenatal testing for the ARX gene is possible through amniocentesis or chorionic villus sampling after thorough genetic counseling, strictly following UAE reproductive health regulations.
UAE Regulatory & Data Privacy Adherence
All patient genetic data is protected under Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Results are shared only with authorized healthcare professionals. Our laboratory is ISO 9001:2015 certified (Cert: INT/EGQ/2509DA/3139) and operates under DHA License 1143.
Clinical & Logistical Metadata
| Test Name | ARX Gene-Associated Agenesis of Corpus Callosum with Abnormal Genitalia (XLAG) Genetic Test |
| Price (AED) | 2,800 |
| Turnaround Time | 3โ4 Weeks |
| Sample Type / Matrix | Peripheral whole blood (3โ5 mL venipuncture) or finger-prick blood spot |
| Methodology Used | Next-Generation Sequencing (NGS) full gene sequencing with CNV detection |
| ICD-10-CM Code | Q04.0 |
| LOINC Code | 80230-8 |
| DHA Facility License & Laboratory Address | DHA License: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | Lab: DNA Labs UAE |
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