Test Price
2,800 AED✅ Home Collection Available
ARX Gene-Associated Agenesis of Corpus Callosum with Abnormal Genitalia (XLAG) Genetic Test in UAE | AED 2800 | 2026 DHA Guidelines
تحليل جين ARX المرتبط بتخلق الجسم الثفني وتشوهات الأعضاء التناسلية في الإمارات | 2800 درهم | معتمد من هيئة الصحة بدبي
Executive Summary | ملخص تنفيذي
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Next-Generation Sequencing (Cert: INT/EGQ/2509DA/3139) for the ARX gene, covering all coding exons and splice sites.
- Premium Logistics: Paid Hospital-Grade Home Collection via ISO Certified Cold-Chain Home Collection and VIP Mobile Phlebotomy available 8 AM – 11 PM daily across the UAE.
- Clinical Guidance: Complimentary telephonic post-test clinical guidance with a genetic counselor to interpret your ARX results within the context of neuroimaging and family history.
- Insurance: Direct Billing Verification via WhatsApp at +971 54 548 8731.
يضمن هذا التحليل تشخيصًا دقيقًا لمتلازمة XLAG بنسبة حساسية 99.9% ويدعم جمع العينات المنزلية المعتمدة من هيئة الصحة.
Overview
This advanced Next-Generation Sequencing (NGS) test analyzes the entire coding region of the ARX gene to detect pathogenic variants linked to X-linked lissencephaly with ambiguous genitalia (XLAG) syndrome and related dysmorphology conditions. يقدم هذا الفحص الدقيق تشخيصًا جزيئيًا نهائيًا يساعد أطباء الأطفال وجراحي الأعصاب والمستشارين الوراثيين في تخطيط العلاج وتقدير احتمالية تكرار الإصابة في العائلة.
| Test Parameter | Our Test (NGS Full Gene Sequencing) | Single-Site Sanger Sequencing |
|---|---|---|
| Methodology | Next-Generation Sequencing (NGS) with high coverage (>200x) and CNV detection | Targeted Sanger sequencing of preselected exons |
| Variant Detection | All coding SNVs, indels, and intragenic copy number variants (CNVs) | Only known specific point mutations; misses novel or CNV changes |
| Turnaround Time | 3–4 Weeks | 1–2 Weeks |
| Clinical Utility | Definitive molecular diagnosis, family screening, and prenatal/preimplantation options | Confirmation of known familial mutation only |
Physician Insight & Safety Protocol
Dr. Prabhakar Reddy (DHA: 61713011), Clinical Geneticist & Head of Precision Diagnostics, notes: “The ARX gene NGS panel provides critical insight into XLAG syndrome, a rare X-linked disorder that demands careful phenotype-genotype correlation. Even with a negative NGS result, other genetic etiologies like chromosomal abnormalities or additional gene panels may need exploration. This test must always be paired with detailed neuroimaging and a comprehensive family pedigree to ensure accurate counseling. Do not discontinue any prescribed medication without consulting your doctor.”
Important Safety Notice & Exclusion Criteria
- This test is indicated only for individuals with clinical features of XLAG syndrome (agenesis of corpus callosum ± genital ambiguity, seizures, severe developmental delay).
- Exclude asymptomatic individuals with no family history of ARX-related disorders, unless part of carrier testing after genetic counseling.
- In the UAE, genetic testing of minors requires explicit consent from a legal guardian and must comply with Federal Decree-Law No. 41 of 2024 (Art. 87) and the 2026 CDS Law on Minors.
- Emergency Red Flags: If your child experiences sudden seizures, respiratory distress, or severe hypotonia after blood collection, seek immediate emergency care. Results that reveal high-risk pathogenic variants should be discussed urgently with your pediatric neurologist.
- All patient data is protected under UAE PDPL; results are shared only with authorized healthcare professionals.
Frequently Asked Questions (FAQ)
1. What is the ARX gene test, and why is it ordered?
The ARX gene test detects disease-causing mutations in the ARX gene to confirm a diagnosis of X-linked lissencephaly with ambiguous genitalia (XLAG) or related syndromes, enabling precise prognosis and genetic counseling. ما هو اختبار جين ARX؟ يكتشف هذا الاختبار الطفرات المرضية في جين ARX لتأكيد تشخيص متلازمة XLAG التي تسبب تخلف الجسم الثفني وتشوهات الأعضاء التناسلية، مما يتيح التنبؤ الدقيق بالمآل وتقديم الاستشارة الوراثية.
2. How is the sample collected, and is it painful?
A simple venous blood draw (3–5 mL) or a painless finger-prick blood spot on an FTA card is collected by our DHA-licensed phlebotomist at your home, with no discomfort beyond a routine blood test. كيف يتم جمع العينة؟ يتم سحب عينة دم وريدي صغيرة أو بقعة دم من الإصبع على بطاقة FTA بواسطة فني معتمد من هيئة الصحة في منزلك، ولا تختلف عن فحص الدم العادي.
3. Can this be performed during pregnancy?
Prenatal testing for the ARX gene is possible through amniocentesis or chorionic villus sampling after thorough genetic counseling, strictly following UAE reproductive health regulations. هل يمكن إجراء الاختبار أثناء الحمل؟ نعم، يمكن فحص جين ARX قبل الولادة عبر عينة من السائل الأمنيوسي أو الزغابات المشيمية بعد استشارة وراثية متخصصة وفقًا للوائح الصحة الإنجابية في الإمارات.
ISO 9001:2015 Certified Facility (Cert: INT/EGQ/2509DA/3139) | DHA License: 9834453 | Genetic counseling appointments: +971 54 548 8731 (WhatsApp available)
© 2026 DNA Labs UAE. All rights reserved. Clinical content reviewed by Dr. Prabhakar Reddy (DHA 61713011).
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توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
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