Test Price
2,800 AED✅ Home Collection Available
AMTN Gene Amelotin Deficiency Genetic Test in UAE | NGS | DNA Labs UAE
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO Accredited Processing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM).
- Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The AMTN gene encodes amelotin, an enamel matrix protein essential for proper enamel formation and epithelial integrity. This NGS test screens for pathogenic variants linked to amelogenesis imperfecta and related dermato-osteological syndromes, enabling precise diagnosis and personalized clinical management.
| Feature | Our NGS Test | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Precision / Sensitivity | 99.9% (full gene coverage) | ~95% (limited to known hotspots) |
| Methodology | Next Generation Sequencing (NGS) – Illumina platform | Capillary Sanger sequencing |
| Turnaround Time | 3-4 Weeks | 2-3 Weeks |
| Deletion/Duplication Detection | Included (CNV analysis) | Not available |
Physician Insight & Safety Protocols
"As a consultant specializing in medical genetics, I emphasize that genetic test results must be interpreted within the full clinical picture; a positive AMTN mutation does not guarantee disease expression and requires correlation with enamel, skin, and bone phenotypes."
- Lina Osama Zaki Quteineh | Consultant Medical Genetics | DHA Registration ID: 9294403
Important Safety Advisory
Do not discontinue prescribed medication or alter treatment plans based solely on genetic test results without consulting your referring physician or a qualified healthcare provider.
Exclusion Criteria & Emergency Red Flags
- Patients under 18 years of age without a legal guardian's informed consent.
- Inability to provide a detailed family history for accurate pedigree construction.
- Blood samples with insufficient DNA yield or severe hemolysis preventing sequencing.
- ER Red Flags:
- Seek immediate medical care if you experience sudden severe dental pain, jaw swelling, or systemic illness following the blood draw procedure.
Patient FAQ & Clinical Guidance
1. What is the clinical utility of the AMTN gene test?
This NGS test identifies pathogenic mutations in the AMTN gene to diagnose amelogenesis imperfecta and guide dermatological and dental management. The result aids in differentiating isolated enamel defects from syndromic forms, allowing targeted interventions and genetic counselling for affected families.
2. Is a blood sample required, and can I use a buccal swab?
The test accepts blood samples (venous whole blood, one drop on FTA card) or previously extracted DNA; buccal swabs are not validated for this specific assay. For home collection, our trained phlebotomist will draw a standard venous sample, ensuring cold-chain transport to the sequencing laboratory.
3. How long do results take and what is the reporting format?
Results are delivered within 3 to 4 weeks as a comprehensive clinical report with variant interpretation based on ACMG guidelines, reviewed by a board-certified geneticist. The report includes the identified variant(s), zygosity, pathogenicity classification, and actionable clinical recommendations. A post-test genetic counselling session is included in the service.
UAE Regulatory & Data Privacy Adherence
Commitment to Data Privacy & Regulatory Compliance
DNA Labs UAE strictly operates in accordance with the highest standards of data protection and healthcare regulations. We adhere to Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All clinical testing and patient consent protocols comply with Federal Decree-Law No. 4 of 2016 on Medical Liability.
Clinical & Logistical Metadata
| Test Name | AMTN Gene Amelotin Deficiency Genetic Test (NGS) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3 to 4 Weeks |
| Sample Type / Matrix | Whole Blood (EDTA/FTA Card) or Extracted DNA |
| Methodology Used | Next-Generation Sequencing (NGS) – Illumina Platform |
| ICD-10-CM Code | K00.5 |
| LOINC Code | 82301-8 |
| DHA Facility License & Address | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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ISMS 27001:2022
ISO Accredited
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All reports reviewed by DHA-Certified physicians