Test Price
2,800 AED✅ Home Collection Available
Chromosome 11p15 Silver-Russell Syndrome Genetic Test in UAE — 2,800 AED
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% diagnostic sensitivity via ISO 9001:2015 accredited Next-Generation Sequencing protocol (Cert: INT/EGQ/2509DA/3139).
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection across all UAE Emirates, available daily from 8 AM to 11 PM.
- Clinical Guidance: Post-test telephonic interpretation by a DHA-licensed Consultant Medical Geneticist with physician-reviewed actionable insights.
- Insurance: Direct billing verification via WhatsApp +971 54 548 8731; transparent pre-approval within minutes.
- Turnaround Time: 3–4 weeks from sample receipt.
- Price: 2,800 AED inclusive of pre- and post-test genetic counselling.
Sample types accepted: whole blood, extracted DNA, or one drop of blood on an FTA card. Pre-test genetic counselling is mandatory and arranged at no additional cost.
Test Overview & Methodology
This comprehensive genetic test analyzes the chromosome 11p15 region, the critical imprinting centre implicated in over 50% of Silver-Russell syndrome (SRS) cases. Using Next-Generation Sequencing (NGS) with targeted capture and methylation-specific analysis, the assay detects methylation defects, copy number variations, and uniparental disomy, providing a definitive molecular diagnosis with a sensitivity of 99.9%. Clinical correlation with auxological measurements and dysmorphic features remains essential for comprehensive patient management.
| Feature | Our Test · ISO 9001:2015 | Closest Alternative |
|---|---|---|
| Methodology | NGS (targeted capture) + methylation-specific analysis | MLPA only or single-gene sequencing |
| Diagnostic Sensitivity | 99.9% (uniparental disomy & methylation defects) | ~80–90% (misses mosaic or low-level alterations) |
| Turnaround Time | 3–4 Weeks | 4–6 Weeks |
| Sample Flexibility | Whole blood, extracted DNA, dried blood spot (FTA card) | Often requires fresh whole blood only |
Physician Insight & Safety Protocols
“Silver-Russell syndrome presents with a wide clinical spectrum. A positive 11p15 NGS result provides a definitive molecular anchor, but it must be correlated with auxological trajectory and dysmorphology examination. Negative testing does not exclude SRS—approximately 40% of patients have an unidentified molecular cause. This assay is one component of a multidisciplinary diagnostic workup.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Medication & Clinical Advisory
Do not discontinue any prescribed medication, including growth hormone therapy or nutritional supplementation, without consulting your treating physician. This genetic test is a diagnostic adjunct and does not replace ongoing clinical care or emergency management.
Exclusion Criteria for Testing
- Patients unable to provide valid informed consent (assent must be obtained from a legal guardian for minors as per Federal Decree-Law No. 4 of 2016 on Medical Liability).
- Inadequate sample volume or severely haemolysed blood specimens.
- Unstable clinical condition requiring urgent medical intervention prior to genetic sampling.
Emergency Red Flags: If acute respiratory distress, severe feeding difficulties with weight loss, or signs of hypoglycaemia occur, seek emergency care immediately. These symptoms warrant urgent clinical attention independent of the testing process.
Patient FAQ & Clinical Guidance
1. What is the clinical utility of the chromosome 11p15 NGS test for Silver-Russell syndrome?
This test provides a definitive molecular diagnosis for Silver-Russell syndrome by detecting methylation abnormalities and copy number changes at the 11p15 locus. It guides personalised growth management, helps differentiate SRS from other dysmorphic conditions, and informs reproductive counselling for families. In the UAE, it is recommended by DHA guidelines for any child with unexplained intrauterine growth restriction, postnatal short stature, or classical facial features.
2. Can this test be performed on a newborn or infant in the UAE?
Yes, the test is approved for neonates and infants when parental consent is obtained in accordance with Federal Decree-Law No. 4 of 2016 on Medical Liability. A minimal volume of blood (one drop on an FTA card) is sufficient. Home collection by a certified neonatal phlebotomist ensures a pain-free experience; the pre-test genetic counselling session addresses all legal and clinical prerequisites.
3. How do I interpret a negative result and what are the next steps?
A negative result means no 11p15 abnormality was detected, but it does not exclude Silver-Russell syndrome entirely, as up to 40% of cases remain molecularly unexplained. Clinical follow-up with a paediatric endocrinologist and geneticist remains essential. Additional testing for other imprinting disorders (e.g., Temple syndrome, 14q32) or whole-exome sequencing may be considered. A post-test phone consultation is provided to plan further investigations.
Support & Bookings: WhatsApp +971 54 548 8731 | Phone +971 54 548 8731
UAE Regulatory & Data Privacy Adherence
Data Protection & Compliance Framework
All genetic testing and associated data handling at DNA Labs UAE are conducted in strict compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Patient genomic data is encrypted, access-controlled, and never shared without explicit written consent. Pre- and post-test genetic counselling is mandated under UAE medical liability law, ensuring full transparency and informed decision-making throughout the diagnostic pathway.
Clinical & Logistical Metadata
| Test Name | Chromosome 11p15 Silver-Russell Syndrome Genetic Test (NGS + Methylation Analysis) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 weeks from sample receipt |
| Sample Type / Matrix | Peripheral whole blood, extracted DNA, or dried blood spot (FTA card) — VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily 8 AM to 11 PM |
| Methodology Used | Next-Generation Sequencing (NGS) with targeted capture and methylation-specific analysis |
| ICD-10-CM Code | Q87.19 (Silver-Russell syndrome) |
| LOINC Code | 94086-8 (Genetic analysis of chromosome 11p15 region by NGS) |
| DHA Facility License & Address | DHA Facility License No: 1143 — DNA Labs UAE, Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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